AutismKB 2.0

Annotation Detail for WWP2


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Basic Information Top
Gene Symbol:WWP2 ( AIP2,WWp2-like )
Gene Full Name: WW domain containing E3 ubiquitin protein ligase 2
Band: 16q22.1
Quick LinksEntrez ID:11060; OMIM: 602308; Uniprot ID:WWP2_HUMAN; ENSEMBL ID: ENSG00000198373; HGNC ID: 16804
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus22 / 56401239
neonate9 / 31097289
infant0 / 236200 
juvenile2 / 5555635
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor14 / 26384553
glioma13 / 106883121
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma10 / 71755139
non-neoplasia13 / 97250133
normal203 / 336030760
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer12 / 102680116
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites4 / 4001599
bladder1 / 2975733
blood6 / 12347848
bone7 / 7165597
bone marrow2 / 4880140
brain99 / 110098989
cervix1 / 4817120
connective tissue24 / 149255160
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye9 / 21105442
heart1 / 8962611
intestine6 / 23447225
kidney11 / 21177751
larynx0 / 241450 
liver2 / 2077439
lung14 / 33697441
lymph6 / 44270135
lymph node3 / 9161032
mammary gland8 / 15327152
mouth2 / 6705229
muscle23 / 107715213
nerve0 / 157680 
ovary4 / 10205139
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta24 / 28082585
prostate16 / 18934584
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach4 / 9661941
testis26 / 33044278
thymus3 / 8113136
thyroid2 / 4747342
tonsil1 / 1699958
trachea42 / 52413801
umbilical cord9 / 13680657
uterus10 / 23287842
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204022_at
Cell line Expression level Expression bar
721_B_lymphoblasts96.05
Adipocyte20.65
AdrenalCortex40.1
Adrenalgland25.75
Amygdala27.75
Appendix26.2
AtrioventricularNode21.1
BDCA4+_DentriticCells141
Bonemarrow43.95
BronchialEpithelialCells22.75
CD105+_Endothelial148.25
CD14+_Monocytes278.75
CD19+_BCells(neg._sel.)149.1
CD33+_Myeloid413.65
CD34+106.1
CD4+_Tcells83.5
CD56+_NKCells330.95
CD71+_EarlyErythroid238.35
CD8+_Tcells81.2
CardiacMyocytes47.8
Caudatenucleus23.2
Cerebellum20.7
CerebellumPeduncles29.95
CiliaryGanglion19.3
CingulateCortex25.75
Colorectaladenocarcinoma26
DorsalRootGanglion20.65
FetalThyroid29.75
Fetalbrain23.55
Fetalliver22.7
Fetallung18.85
GlobusPallidus19.05
Heart52.1
Hypothalamus49.2
Kidney21.4
Leukemia_chronicMyelogenousK-56226.45
Leukemia_promyelocytic-HL-6022.9
Leukemialymphoblastic(MOLT-4)20.35
Liver38.05
Lung181
Lymphnode22.25
Lymphoma_burkitts(Daudi)33.15
Lymphoma_burkitts(Raji)41.55
MedullaOblongata19
OccipitalLobe20.35
OlfactoryBulb20.45
Ovary17.55
Pancreas23.95
PancreaticIslet37.05
ParietalLobe24.1
Pituitary30.5
Placenta44.1
Pons21.95
PrefrontalCortex31.55
Prostate68.45
Salivarygland20.8
SkeletalMuscle30.35
Skin20.3
SmoothMuscle30.3
Spinalcord30.95
SubthalamicNucleus23.6
SuperiorCervicalGanglion29.65
TemporalLobe22.4
Testis56
TestisGermCell33.5
TestisIntersitial23.5
TestisLeydigCell25.7
TestisSeminiferousTubule22.05
Thalamus26.55
Thymus41
Thyroid33.65
Tongue25.75
Tonsil23.3
Trachea27.8
TrigeminalGanglion35.55
Uterus31.5
UterusCorpus21.85
WholeBlood233.55
Wholebrain40.3
colon25.95
pineal_day43.8
pineal_night32.52
retina54.3
small_intestine30.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P357147
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.11 ± 0.66
Basal Forebrain4.02 ± 0.44
Basal Part of Pons4.46 ± 0.34
Cerebellar Cortex4.1 ± 0.54
Cerebellar Nuclei4.32 ± 0.39
Claustrum4.32 ± 0.79
Epithalamus4.25 ± 0.71
Frontal Lobe4.2 ± 0.49
Globus Pallidus4.52 ± 0.41
Hypothalamus3.67 ± 0.57
Insula4.07 ± 0.33
Limbic Lobe4.15 ± 0.56
Mesencephalon4.3 ± 0.52
Myelencephalon4.21 ± 0.55
Occipital Lobe4.22 ± 0.4
Parietal Lobe4.14 ± 0.55
Pontine Tegmentum4.13 ± 0.5
Striatum4.42 ± 0.66
Subthalamus3.74 ± 0.38
Temporal Lobe4.28 ± 0.44
Thalamus4.3 ± 0.44
White Matter5.41 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wwp2CBCerebellum3.61
4.15
Wwp2CTXCerebral cortex9.19
7.29
Wwp2HIPHippocampal region5.01
5.16
Wwp2HPFHippocampal formation4.09
3.91
Wwp2HYHypothalamus1.99
1.8
Wwp2LSXLateral septal complex0.76
0.58
Wwp2MBMidbrain5.14
5.86
Wwp2MYMedulla2.03
3.11
Wwp2OLFOlfactory bulb6
5.49
Wwp2PPons5.65
7.08
Wwp2PALPallidum0.73
0.84
Wwp2RHPRetrohippocampal region2.05
1.71
Wwp2sAMYStriatum-like amygdalar nuclei2.18
1.8
Wwp2STRStriatum0.57
0.54
Wwp2STRdStriatum dorsal region0.39
0.4
Wwp2STRvStriatum ventral region0.42
0.37
Wwp2THThalamus2.98
2.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00018019 7 835 841 SHTCFNR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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