AutismKB 2.0

Annotation Detail for CHD3


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Basic Information Top
Gene Symbol:CHD3 ( Mi-2a,Mi2-ALPHA,ZFH )
Gene Full Name: chromodomain helicase DNA binding protein 3
Band: 17p13.1
Quick LinksEntrez ID:1107; OMIM: 602120; Uniprot ID:CHD3_HUMAN; ENSEMBL ID: ENSG00000170004; HGNC ID: 1918
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst1 / 6231916
fetus93 / 564012164
neonate2 / 3109764
infant0 / 236200 
juvenile6 / 55556107
adult216 / 1939121111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor18 / 94178191
cervical tumor5 / 34366145
chondrosarcoma8 / 8282396
colorectal tumor17 / 114246148
esophageal tumor3 / 17290173
gastrointestinal tumor9 / 11936975
germ cell tumor22 / 26384583
glioma11 / 106883102
head and neck tumor32 / 136302234
kidney tumor8 / 68959116
leukemia14 / 95842146
liver tumor7 / 9635972
lung tumor27 / 103127261
lymphoma19 / 71755264
non-neoplasia9 / 9725092
normal337 / 3360307100
ovarian tumor6 / 7668278
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer16 / 102680155
retinoblastoma4 / 4635686
skin tumor7 / 12494956
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor13 / 90257144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood12 / 12347897
bone9 / 71655125
bone marrow0 / 488010 
brain150 / 1100989136
cervix5 / 48171103
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue24 / 215722111
esophagus3 / 20209148
eye28 / 211054132
heart6 / 8962666
intestine22 / 23447293
kidney11 / 21177751
larynx9 / 24145372
liver16 / 20774377
lung48 / 336974142
lymph16 / 44270361
lymph node32 / 91610349
mammary gland21 / 153271137
mouth22 / 67052328
muscle4 / 10771537
nerve3 / 15768190
ovary8 / 10205178
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta7 / 28082524
prostate35 / 189345184
salivary gland0 / 201550 
skin12 / 21057456
spleen1 / 5395218
stomach9 / 9661993
testis17 / 33044251
thymus22 / 81131271
thyroid9 / 47473189
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord1 / 1368073
uterus25 / 232878107
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208806_at
Cell line Expression level Expression bar
721_B_lymphoblasts33.85
Adipocyte18.55
AdrenalCortex26.7
Adrenalgland16.05
Amygdala70.6
Appendix19.25
AtrioventricularNode13.45
BDCA4+_DentriticCells32.8
Bonemarrow18.8
BronchialEpithelialCells17.3
CD105+_Endothelial22.6
CD14+_Monocytes23.35
CD19+_BCells(neg._sel.)22.75
CD33+_Myeloid40.55
CD34+74.65
CD4+_Tcells70.5
CD56+_NKCells30.15
CD71+_EarlyErythroid17.7
CD8+_Tcells95.95
CardiacMyocytes21.45
Caudatenucleus23.8
Cerebellum15.3
CerebellumPeduncles21.6
CiliaryGanglion12.3
CingulateCortex50.8
Colorectaladenocarcinoma18.9
DorsalRootGanglion14
FetalThyroid18.2
Fetalbrain359.05
Fetalliver16.4
Fetallung15.5
GlobusPallidus17.7
Heart21.95
Hypothalamus24.7
Kidney15.55
Leukemia_chronicMyelogenousK-56217.05
Leukemia_promyelocytic-HL-6026
Leukemialymphoblastic(MOLT-4)17.1
Liver25.25
Lung19.25
Lymphnode32.85
Lymphoma_burkitts(Daudi)36.95
Lymphoma_burkitts(Raji)47.85
MedullaOblongata30.8
OccipitalLobe31
OlfactoryBulb14.2
Ovary12.6
Pancreas14.5
PancreaticIslet17
ParietalLobe26.25
Pituitary21.9
Placenta16.55
Pons35.85
PrefrontalCortex72.65
Prostate27.55
Salivarygland23.9
SkeletalMuscle22.3
Skin13.6
SmoothMuscle21.3
Spinalcord20.25
SubthalamicNucleus19.2
SuperiorCervicalGanglion30.8
TemporalLobe26.5
Testis16.05
TestisGermCell17.1
TestisIntersitial15.45
TestisLeydigCell18.15
TestisSeminiferousTubule18.55
Thalamus37.55
Thymus27.1
Thyroid23
Tongue18.65
Tonsil18.9
Trachea14.9
TrigeminalGanglion19.15
Uterus18.25
UterusCorpus20.25
WholeBlood21.05
Wholebrain16.5
colon17.55
pineal_day38.04
pineal_night48.62
retina29.725
small_intestine18.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11452_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.73 ± 0.85
Basal Forebrain6.95 ± 0.18
Basal Part of Pons5.72 ± 0.23
Cerebellar Cortex5.97 ± 0.47
Cerebellar Nuclei5.51 ± 0.4
Claustrum7.78 ± 0.98
Epithalamus5.12 ± 0.78
Frontal Lobe6.35 ± 0.7
Globus Pallidus6.35 ± 0.66
Hypothalamus6.05 ± 0.51
Insula6.58 ± 0.76
Limbic Lobe7.25 ± 0.69
Mesencephalon6.68 ± 0.72
Myelencephalon6.69 ± 0.9
Occipital Lobe7.01 ± 0.81
Parietal Lobe6.65 ± 0.87
Pontine Tegmentum6.76 ± 0.64
Striatum7.41 ± 0.73
Subthalamus6.04 ± 0.44
Temporal Lobe6.66 ± 0.7
Thalamus6.49 ± 0.68
White Matter4.64 ± 1.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Chd3CBCerebellum56.75
100
Chd3CTXCerebral cortex100
100
Chd3HIPHippocampal region100
100
Chd3HPFHippocampal formation100
100
Chd3HYHypothalamus100
100
Chd3LSXLateral septal complex100
100
Chd3MBMidbrain100
100
Chd3MYMedulla40.6
56.21
Chd3OLFOlfactory bulb100
100
Chd3PPons77.54
100
Chd3PALPallidum100
100
Chd3RHPRetrohippocampal region100
100
Chd3sAMYStriatum-like amygdalar nuclei100
100
Chd3STRStriatum100
100
Chd3STRdStriatum dorsal region100
100
Chd3STRvStriatum ventral region100
100
Chd3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CHD3_HUMAN_1202 15 1202 1216 MMLTHLVVRPGLGSK PRIDE
PAp00010103 16 1122 1137 FNAPGAQQFCFLLSTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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