AutismKB 2.0

Annotation Detail for TMEM115


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Basic Information Top
Gene Symbol:TMEM115 ( PL6 )
Gene Full Name: transmembrane protein 115
Band: 3p21.31
Quick LinksEntrez ID:11070; OMIM: 607069; Uniprot ID:TM115_HUMAN; ENSEMBL ID: ENSG00000126062; HGNC ID: 30055
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult70 / 193912136
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma13 / 82823156
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor20 / 26384575
glioma13 / 106883121
head and neck tumor0 / 1363020 
kidney tumor7 / 68959101
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal92 / 336030727
ovarian tumor6 / 7668278
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer12 / 102680116
retinoblastoma3 / 4635664
skin tumor14 / 124949112
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone4 / 7165555
bone marrow0 / 488010 
brain36 / 110098932
cervix8 / 48171166
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye14 / 21105466
heart0 / 896260 
intestine4 / 23447217
kidney10 / 21177747
larynx0 / 241450 
liver4 / 20774319
lung12 / 33697435
lymph1 / 4427022
lymph node1 / 9161010
mammary gland6 / 15327139
mouth0 / 670520 
muscle6 / 10771555
nerve0 / 157680 
ovary19 / 102051186
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta13 / 28082546
prostate17 / 18934589
salivary gland0 / 201550 
skin15 / 21057471
spleen3 / 5395255
stomach0 / 966190 
testis3 / 3304429
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216267_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.15
Adipocyte13.25
AdrenalCortex11.85
Adrenalgland15.65
Amygdala11.7
Appendix11.15
AtrioventricularNode7.15
BDCA4+_DentriticCells18.5
Bonemarrow11.3
BronchialEpithelialCells16.9
CD105+_Endothelial12.25
CD14+_Monocytes13.9
CD19+_BCells(neg._sel.)15.5
CD33+_Myeloid12.2
CD34+11.85
CD4+_Tcells11.5
CD56+_NKCells17.35
CD71+_EarlyErythroid14.9
CD8+_Tcells11.75
CardiacMyocytes21.55
Caudatenucleus10.1
Cerebellum9.45
CerebellumPeduncles13.6
CiliaryGanglion7.1
CingulateCortex13.65
Colorectaladenocarcinoma22.3
DorsalRootGanglion7.6
FetalThyroid18.3
Fetalbrain9.75
Fetalliver10.55
Fetallung11.55
GlobusPallidus7.6
Heart57
Hypothalamus12.1
Kidney12.5
Leukemia_chronicMyelogenousK-5628.95
Leukemia_promyelocytic-HL-608.4
Leukemialymphoblastic(MOLT-4)9.8
Liver24.15
Lung55.35
Lymphnode9.6
Lymphoma_burkitts(Daudi)12.55
Lymphoma_burkitts(Raji)15.05
MedullaOblongata9.45
OccipitalLobe10.85
OlfactoryBulb8.3
Ovary7.55
Pancreas8.5
PancreaticIslet13.65
ParietalLobe11.35
Pituitary11.85
Placenta49.65
Pons13.15
PrefrontalCortex15.2
Prostate20.95
Salivarygland7.2
SkeletalMuscle13.95
Skin7.65
SmoothMuscle20
Spinalcord12.25
SubthalamicNucleus9.4
SuperiorCervicalGanglion13
TemporalLobe9.85
Testis12.85
TestisGermCell8.4
TestisIntersitial8.3
TestisLeydigCell10.2
TestisSeminiferousTubule8.9
Thalamus10.6
Thymus10.25
Thyroid50.2
Tongue11.2
Tonsil10.7
Trachea10.6
TrigeminalGanglion11.2
Uterus11.9
UterusCorpus10.4
WholeBlood17.5
Wholebrain19.85
colon11.05
pineal_day12.02
pineal_night14.44
retina24
small_intestine13.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P6869
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.51 ± 0.79
Basal Forebrain3.53 ± 0.33
Basal Part of Pons4.05 ± 0.76
Cerebellar Cortex3.88 ± 0.63
Cerebellar Nuclei3.48 ± 0.6
Claustrum3.88 ± 1.37
Epithalamus3.78 ± 0.56
Frontal Lobe3.83 ± 0.57
Globus Pallidus3.6 ± 0.41
Hypothalamus3.54 ± 0.58
Insula3.56 ± 0.61
Limbic Lobe3.7 ± 0.62
Mesencephalon3.83 ± 0.75
Myelencephalon3.74 ± 0.62
Occipital Lobe3.43 ± 0.57
Parietal Lobe3.64 ± 0.6
Pontine Tegmentum3.68 ± 0.48
Striatum3.35 ± 0.73
Subthalamus4.01 ± 0.4
Temporal Lobe3.82 ± 0.58
Thalamus3.74 ± 0.48
White Matter3.62 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem115CBCerebellum2.71
3.68
Tmem115CTXCerebral cortex0.91
1.35
Tmem115HIPHippocampal region4.03
3.8
Tmem115HPFHippocampal formation5.44
5.2
Tmem115HYHypothalamus2.32
2.15
Tmem115LSXLateral septal complex0.22
0.18
Tmem115MBMidbrain0.53
1.55
Tmem115MYMedulla0.89
1.61
Tmem115OLFOlfactory bulb3.51
3.51
Tmem115PPons1.67
3.92
Tmem115PALPallidum0.84
0.79
Tmem115RHPRetrohippocampal region8.57
7.73
Tmem115sAMYStriatum-like amygdalar nuclei4.17
3.67
Tmem115STRStriatum0.69
0.62
Tmem115STRdStriatum dorsal region0.22
0.21
Tmem115STRvStriatum ventral region1.07
0.9
Tmem115THThalamus0.53
0.61
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00042410 24 259 282 RYDVGAPSSITISLPGTDPQDAER Peptide Atlas
TM115_HUMAN_151 10 151 160 QTMGDCVVLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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