AutismKB 2.0

Annotation Detail for DUSP14


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Basic Information Top
Gene Symbol:DUSP14 ( MKP-L,MKP6 )
Gene Full Name: dual specificity phosphatase 14
Band: 17q12
Quick LinksEntrez ID:11072; OMIM: 606618; Uniprot ID:DUS14_HUMAN; ENSEMBL ID: ENSG00000161326; HGNC ID: 17007
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor4 / 26384515
glioma4 / 10688337
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor4 / 9635941
lung tumor9 / 10312787
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal80 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood5 / 12347840
bone5 / 7165569
bone marrow0 / 488010 
brain21 / 110098919
cervix6 / 48171124
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine8 / 23447234
kidney5 / 21177723
larynx1 / 2414541
liver5 / 20774324
lung13 / 33697438
lymph0 / 442700 
lymph node3 / 9161032
mammary gland2 / 15327113
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta13 / 28082546
prostate6 / 18934531
salivary gland1 / 2015549
skin9 / 21057442
spleen0 / 539520 
stomach3 / 9661931
testis1 / 3304423
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203367_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.6
Adipocyte18
AdrenalCortex5.65
Adrenalgland4.7
Amygdala9.25
Appendix5.55
AtrioventricularNode4.15
BDCA4+_DentriticCells5.6
Bonemarrow5.35
BronchialEpithelialCells65.8
CD105+_Endothelial5.6
CD14+_Monocytes5.95
CD19+_BCells(neg._sel.)5.45
CD33+_Myeloid6.5
CD34+7.6
CD4+_Tcells6
CD56+_NKCells7.25
CD71+_EarlyErythroid4.8
CD8+_Tcells5.15
CardiacMyocytes7.15
Caudatenucleus7.2
Cerebellum5.6
CerebellumPeduncles6.25
CiliaryGanglion3.85
CingulateCortex7.7
Colorectaladenocarcinoma28.25
DorsalRootGanglion4.2
FetalThyroid7.45
Fetalbrain5.05
Fetalliver4.85
Fetallung4.25
GlobusPallidus4.05
Heart11.6
Hypothalamus6.2
Kidney4.4
Leukemia_chronicMyelogenousK-5625.55
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)7.75
Liver9.25
Lung6.3
Lymphnode4.25
Lymphoma_burkitts(Daudi)7.55
Lymphoma_burkitts(Raji)7.65
MedullaOblongata5.2
OccipitalLobe5.45
OlfactoryBulb4.6
Ovary3.6
Pancreas4.35
PancreaticIslet5.65
ParietalLobe5.75
Pituitary6.65
Placenta16.6
Pons5.2
PrefrontalCortex8.8
Prostate9.65
Salivarygland4.5
SkeletalMuscle6.2
Skin4.15
SmoothMuscle9.4
Spinalcord6.05
SubthalamicNucleus5.3
SuperiorCervicalGanglion6.15
TemporalLobe4.95
Testis19.6
TestisGermCell6.9
TestisIntersitial4.75
TestisLeydigCell5.5
TestisSeminiferousTubule5.3
Thalamus5.85
Thymus7.7
Thyroid34.3
Tongue5.25
Tonsil5.35
Trachea10.85
TrigeminalGanglion5.4
Uterus5.9
UterusCorpus4.9
WholeBlood5.95
Wholebrain45.1
colon5.4
pineal_day24.66
pineal_night33.96
retina10.225
small_intestine5.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8105_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.77 ± 0.53
Basal Forebrain5.15 ± 0.14
Basal Part of Pons4.71 ± 0.56
Cerebellar Cortex4.72 ± 0.52
Cerebellar Nuclei4.79 ± 0.63
Claustrum6.25 ± 0.62
Epithalamus5.38 ± 0.88
Frontal Lobe5.16 ± 0.56
Globus Pallidus4.63 ± 0.58
Hypothalamus5.17 ± 1.23
Insula5.09 ± 0.82
Limbic Lobe5.44 ± 0.66
Mesencephalon5.06 ± 0.73
Myelencephalon5.28 ± 0.62
Occipital Lobe5.55 ± 0.62
Parietal Lobe5.29 ± 0.63
Pontine Tegmentum5.44 ± 0.67
Striatum6.25 ± 0.5
Subthalamus5.16 ± 0.44
Temporal Lobe5.37 ± 0.53
Thalamus5.29 ± 0.49
White Matter3.65 ± 1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dusp14CBCerebellum27.97
32.33
Dusp14CTXCerebral cortex100
100
Dusp14HIPHippocampal region77.72
100
Dusp14HPFHippocampal formation80.11
100
Dusp14HYHypothalamus16.81
14.97
Dusp14LSXLateral septal complex42.86
40.73
Dusp14MBMidbrain16.77
16.94
Dusp14MYMedulla24.84
29.97
Dusp14OLFOlfactory bulb100
100
Dusp14PPons19.91
23.37
Dusp14PALPallidum23.8
24.06
Dusp14RHPRetrohippocampal region86.22
87.47
Dusp14sAMYStriatum-like amygdalar nuclei41.71
35.24
Dusp14STRStriatum86.18
86.54
Dusp14STRdStriatum dorsal region94.14
98.09
Dusp14STRvStriatum ventral region99.03
91.91
Dusp14THThalamus45.58
45.59
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00429673 21 76 96 VPLADMPHAPIGLYFDTVADK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018