AutismKB 2.0

Annotation Detail for PRSS23


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Basic Information Top
Gene Symbol:PRSS23 ( MGC5107,SIG13,SPUVE,ZSIG13 )
Gene Full Name: protease, serine, 23
Band: 11q14.2
Quick LinksEntrez ID:11098; OMIM: NA; Uniprot ID:PRS23_HUMAN; ENSEMBL ID: ENSG00000150687; HGNC ID: 14370
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202458_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.6
Adipocyte350.15
AdrenalCortex19
Adrenalgland24
Amygdala14.5
Appendix47.15
AtrioventricularNode14.95
BDCA4+_DentriticCells10.3
Bonemarrow15.9
BronchialEpithelialCells435.15
CD105+_Endothelial12.4
CD14+_Monocytes13.1
CD19+_BCells(neg._sel.)13.8
CD33+_Myeloid13.65
CD34+17.85
CD4+_Tcells14
CD56+_NKCells290.3
CD71+_EarlyErythroid13.15
CD8+_Tcells12.6
CardiacMyocytes977.9
Caudatenucleus15.4
Cerebellum13.7
CerebellumPeduncles19.7
CiliaryGanglion28.8
CingulateCortex15.8
Colorectaladenocarcinoma39.7
DorsalRootGanglion13.95
FetalThyroid20.1
Fetalbrain13.9
Fetalliver13.05
Fetallung38
GlobusPallidus12.8
Heart17.95
Hypothalamus17.55
Kidney49.7
Leukemia_chronicMyelogenousK-56215.15
Leukemia_promyelocytic-HL-6012.3
Leukemialymphoblastic(MOLT-4)11.8
Liver21.5
Lung451.6
Lymphnode36.85
Lymphoma_burkitts(Daudi)19.85
Lymphoma_burkitts(Raji)20.1
MedullaOblongata14.35
OccipitalLobe13.6
OlfactoryBulb58.7
Ovary11.15
Pancreas27.55
PancreaticIslet84.05
ParietalLobe17.1
Pituitary44.3
Placenta149.5
Pons24.1
PrefrontalCortex17
Prostate150.35
Salivarygland28.5
SkeletalMuscle22
Skin14.5
SmoothMuscle370.85
Spinalcord18
SubthalamicNucleus15.75
SuperiorCervicalGanglion26.25
TemporalLobe15.7
Testis33.35
TestisGermCell93.1
TestisIntersitial19.45
TestisLeydigCell34.75
TestisSeminiferousTubule25.75
Thalamus16
Thymus15.95
Thyroid125.6
Tongue17.35
Tonsil16.35
Trachea360.15
TrigeminalGanglion18.6
Uterus204.25
UterusCorpus69.7
WholeBlood21.3
Wholebrain11.65
colon234.6
pineal_day22.2
pineal_night25.02
retina141
small_intestine191.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P150789
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.63 ± 0.64
Basal Forebrain4.59 ± 0.6
Basal Part of Pons6.31 ± 0.17
Cerebellar Cortex4.62 ± 0.54
Cerebellar Nuclei5.16 ± 0.51
Claustrum4.5 ± 1.05
Epithalamus5.35 ± 0.6
Frontal Lobe5.4 ± 0.56
Globus Pallidus5.5 ± 0.39
Hypothalamus5.24 ± 0.36
Insula5.86 ± 0.44
Limbic Lobe5.14 ± 0.62
Mesencephalon5.26 ± 0.62
Myelencephalon5.2 ± 0.79
Occipital Lobe4.71 ± 0.58
Parietal Lobe5.02 ± 0.63
Pontine Tegmentum5.01 ± 0.5
Striatum5.81 ± 0.41
Subthalamus5.24 ± 0.81
Temporal Lobe5.38 ± 0.67
Thalamus5.86 ± 0.67
White Matter4.28 ± 0.82
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prss23CBCerebellum8.24
10.46
Prss23CTXCerebral cortex20.62
20.84
Prss23HIPHippocampal region11.22
16.31
Prss23HPFHippocampal formation8.7
10.97
Prss23HYHypothalamus2.48
2.62
Prss23LSXLateral septal complex15.67
17.14
Prss23MBMidbrain1.75
2.69
Prss23MYMedulla5.43
6.77
Prss23OLFOlfactory bulb41.49
43.54
Prss23PPons5.93
7.52
Prss23PALPallidum2.69
2.6
Prss23RHPRetrohippocampal region4.24
3.89
Prss23sAMYStriatum-like amygdalar nuclei5.65
5.75
Prss23STRStriatum4.42
4.38
Prss23STRdStriatum dorsal region2.65
2.56
Prss23STRvStriatum ventral region5.52
4.87
Prss23THThalamus2.05
2.73
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00375635 22 37 58 LPVVLPQSTLNLAKPDFGAEAK Peptide Atlas

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018