AutismKB 2.0

Annotation Detail for PRDM4


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Basic Information Top
Gene Symbol:PRDM4 ( MGC45046,PFM1 )
Gene Full Name: PR domain containing 4
Band: 12q23.3
Quick LinksEntrez ID:11108; OMIM: 605780; Uniprot ID:PRDM4_HUMAN; ENSEMBL ID: ENSG00000110851; HGNC ID: 9348
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst5 / 6231980
fetus29 / 56401251
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor4 / 34366116
chondrosarcoma7 / 8282384
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor1 / 1193698
germ cell tumor11 / 26384541
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal111 / 336030733
ovarian tumor2 / 7668226
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood6 / 12347848
bone6 / 7165583
bone marrow0 / 488010 
brain21 / 110098919
cervix4 / 4817183
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye4 / 21105418
heart4 / 8962644
intestine4 / 23447217
kidney11 / 21177751
larynx0 / 241450 
liver3 / 20774314
lung18 / 33697453
lymph0 / 442700 
lymph node5 / 9161054
mammary gland9 / 15327158
mouth3 / 6705244
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate4 / 18934521
salivary gland0 / 201550 
skin5 / 21057423
spleen1 / 5395218
stomach0 / 966190 
testis7 / 33044221
thymus1 / 8113112
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218329_at
Cell line Expression level Expression bar
721_B_lymphoblasts150.85
Adipocyte73.05
AdrenalCortex75.15
Adrenalgland61.3
Amygdala112.6
Appendix90.8
AtrioventricularNode56.05
BDCA4+_DentriticCells152.6
Bonemarrow72.55
BronchialEpithelialCells113.1
CD105+_Endothelial115.1
CD14+_Monocytes104.1
CD19+_BCells(neg._sel.)472.6
CD33+_Myeloid127.9
CD34+249.9
CD4+_Tcells213.25
CD56+_NKCells202.2
CD71+_EarlyErythroid62.85
CD8+_Tcells192.8
CardiacMyocytes108.85
Caudatenucleus64.05
Cerebellum59.05
CerebellumPeduncles83.15
CiliaryGanglion50.45
CingulateCortex112.55
Colorectaladenocarcinoma71.1
DorsalRootGanglion59.7
FetalThyroid71.65
Fetalbrain74.45
Fetalliver63.35
Fetallung61.7
GlobusPallidus52.15
Heart89.4
Hypothalamus93.45
Kidney58.85
Leukemia_chronicMyelogenousK-56269.8
Leukemia_promyelocytic-HL-6066.2
Leukemialymphoblastic(MOLT-4)66.55
Liver96.3
Lung81.9
Lymphnode72.1
Lymphoma_burkitts(Daudi)141
Lymphoma_burkitts(Raji)102.05
MedullaOblongata78.1
OccipitalLobe66.7
OlfactoryBulb73.9
Ovary48.7
Pancreas65.4
PancreaticIslet90.65
ParietalLobe77.05
Pituitary93.95
Placenta74.75
Pons71.9
PrefrontalCortex101.95
Prostate87.65
Salivarygland80.5
SkeletalMuscle82.6
Skin55.6
SmoothMuscle99.35
Spinalcord83.65
SubthalamicNucleus64.5
SuperiorCervicalGanglion81.7
TemporalLobe66.9
Testis63.65
TestisGermCell66.05
TestisIntersitial61.95
TestisLeydigCell72.65
TestisSeminiferousTubule67
Thalamus74.85
Thymus58.55
Thyroid93.75
Tongue71.1
Tonsil71.95
Trachea61.35
TrigeminalGanglion70.7
Uterus71.55
UterusCorpus79.25
WholeBlood81.65
Wholebrain63.9
colon79.6
pineal_day425.44
pineal_night446.16
retina97.85
small_intestine71.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1015_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.46 ± 0.27
Basal Forebrain7.62 ± 0.1
Basal Part of Pons7.83 ± 0.07
Cerebellar Cortex7.63 ± 0.18
Cerebellar Nuclei7.56 ± 0.19
Claustrum7.65 ± 0.19
Epithalamus7.43 ± 0.21
Frontal Lobe7.6 ± 0.25
Globus Pallidus7.17 ± 0.26
Hypothalamus7.69 ± 0.31
Insula7.63 ± 0.29
Limbic Lobe7.59 ± 0.24
Mesencephalon7.62 ± 0.26
Myelencephalon7.58 ± 0.28
Occipital Lobe7.61 ± 0.26
Parietal Lobe7.72 ± 0.22
Pontine Tegmentum7.6 ± 0.22
Striatum7.63 ± 0.21
Subthalamus7.76 ± 0.08
Temporal Lobe7.69 ± 0.2
Thalamus7.7 ± 0.23
White Matter7.51 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prdm4CBCerebellum10.6
10.53
Prdm4CTXCerebral cortex21.21
14.62
Prdm4HIPHippocampal region13.2
12.77
Prdm4HPFHippocampal formation13.63
11.67
Prdm4HYHypothalamus4.61
3.41
Prdm4LSXLateral septal complex4.64
3.1
Prdm4MBMidbrain6.42
5.98
Prdm4MYMedulla11.43
13.26
Prdm4OLFOlfactory bulb23.86
18.05
Prdm4PPons9.01
9.87
Prdm4PALPallidum7.45
6.19
Prdm4RHPRetrohippocampal region14.73
10.37
Prdm4sAMYStriatum-like amygdalar nuclei8.98
5.88
Prdm4STRStriatum9.17
6.25
Prdm4STRdStriatum dorsal region8.77
6.18
Prdm4STRvStriatum ventral region12.69
7.81
Prdm4THThalamus8.89
7.02
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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