AutismKB 2.0

Annotation Detail for PTPRT


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Basic Information Top
Gene Symbol:PTPRT ( KIAA0283,RPTPrho )
Gene Full Name: protein tyrosine phosphatase, receptor type, T
Band: 20q12-q13.11
Quick LinksEntrez ID:11122; OMIM: 608712; Uniprot ID:PTPRT_HUMAN; ENSEMBL ID: ENSG00000196090; HGNC ID: 9682
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal43 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain29 / 110098926
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye7 / 21105433
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle7 / 10771564
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205948_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.5
Adipocyte4.6
AdrenalCortex5.1
Adrenalgland3.95
Amygdala5.65
Appendix8.1
AtrioventricularNode5.1
BDCA4+_DentriticCells5
Bonemarrow4.5
BronchialEpithelialCells4.5
CD105+_Endothelial4.6
CD14+_Monocytes4.85
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid5.75
CD34+5.9
CD4+_Tcells4.9
CD56+_NKCells5.45
CD71+_EarlyErythroid4.3
CD8+_Tcells4.3
CardiacMyocytes5.85
Caudatenucleus9.55
Cerebellum3.75
CerebellumPeduncles6.05
CiliaryGanglion5.1
CingulateCortex17.9
Colorectaladenocarcinoma4.55
DorsalRootGanglion7
FetalThyroid4.45
Fetalbrain5.75
Fetalliver6.05
Fetallung3.8
GlobusPallidus7.35
Heart6.35
Hypothalamus5.7
Kidney4.3
Leukemia_chronicMyelogenousK-5624.2
Leukemia_promyelocytic-HL-604.1
Leukemialymphoblastic(MOLT-4)3.7
Liver13.2
Lung5.15
Lymphnode4.05
Lymphoma_burkitts(Daudi)5.95
Lymphoma_burkitts(Raji)6.45
MedullaOblongata14.75
OccipitalLobe7.4
OlfactoryBulb3.65
Ovary3.05
Pancreas3.75
PancreaticIslet4.95
ParietalLobe18.65
Pituitary7.7
Placenta4.85
Pons18.65
PrefrontalCortex32.6
Prostate5.4
Salivarygland4.25
SkeletalMuscle5.3
Skin5.1
SmoothMuscle5.25
Spinalcord4.95
SubthalamicNucleus14.6
SuperiorCervicalGanglion9.75
TemporalLobe11.25
Testis4.15
TestisGermCell3.9
TestisIntersitial3.9
TestisLeydigCell4.55
TestisSeminiferousTubule4
Thalamus4.7
Thymus3.75
Thyroid5.8
Tongue4.6
Tonsil4.5
Trachea3.85
TrigeminalGanglion5.55
Uterus3.8
UterusCorpus4.15
WholeBlood4.95
Wholebrain4.5
colon4.7
pineal_day5.72
pineal_night5.52
retina5.6
small_intestine4.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P36404
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.03 ± 0.51
Basal Forebrain10.15 ± 0.16
Basal Part of Pons10.32 ± 0.27
Cerebellar Cortex9.08 ± 0.25
Cerebellar Nuclei10.04 ± 0.43
Claustrum10.77 ± 0.27
Epithalamus8.28 ± 0.84
Frontal Lobe9.9 ± 0.6
Globus Pallidus7.37 ± 1.58
Hypothalamus9.71 ± 1.1
Insula10.12 ± 0.33
Limbic Lobe9.78 ± 0.93
Mesencephalon9.8 ± 1.25
Myelencephalon9.93 ± 0.71
Occipital Lobe10.4 ± 0.49
Parietal Lobe10.02 ± 0.64
Pontine Tegmentum9.92 ± 0.52
Striatum9.69 ± 1.16
Subthalamus8.87 ± 0.34
Temporal Lobe9.9 ± 0.48
Thalamus9.45 ± 0.58
White Matter7.65 ± 1.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PtprtCBCerebellum0.51
0.93
PtprtCTXCerebral cortex1.75
1.36
PtprtHIPHippocampal region1.64
1.74
PtprtHPFHippocampal formation1.19
1.14
PtprtHYHypothalamus0.07
0.15
PtprtLSXLateral septal complex1.2
1.33
PtprtMBMidbrain0.21
0.34
PtprtMYMedulla0.63
0.96
PtprtOLFOlfactory bulb2.71
2.8
PtprtPPons0.18
0.25
PtprtPALPallidum0.68
0.9
PtprtRHPRetrohippocampal region0.64
0.51
PtprtsAMYStriatum-like amygdalar nuclei0.31
0.24
PtprtSTRStriatum0.7
0.6
PtprtSTRdStriatum dorsal region0.72
0.6
PtprtSTRvStriatum ventral region0.56
0.38
PtprtTHThalamus0.22
0.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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