AutismKB 2.0

Annotation Detail for POLR3A


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Basic Information Top
Gene Symbol:POLR3A ( RPC1,RPC155,hRPC155 )
Gene Full Name: polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Band: 10q22.3
Quick LinksEntrez ID:11128; OMIM: NA; Uniprot ID:RPC1_HUMAN; ENSEMBL ID: ENSG00000148606; HGNC ID: 30074
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst6 / 6231996
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult65 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor12 / 114246105
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor11 / 26384541
glioma4 / 10688337
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal122 / 336030736
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood4 / 12347832
bone3 / 7165541
bone marrow1 / 4880120
brain57 / 110098951
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye10 / 21105447
heart2 / 8962622
intestine16 / 23447268
kidney5 / 21177723
larynx1 / 2414541
liver6 / 20774328
lung10 / 33697429
lymph2 / 4427045
lymph node4 / 9161043
mammary gland8 / 15327152
mouth2 / 6705229
muscle6 / 10771555
nerve1 / 1576863
ovary6 / 10205158
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate4 / 18934521
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach1 / 9661910
testis10 / 33044230
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P85283
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.35 ± 0.29
Basal Forebrain7.02 ± 0.24
Basal Part of Pons7.77 ± 0.29
Cerebellar Cortex7.28 ± 0.18
Cerebellar Nuclei6.93 ± 0.55
Claustrum7.37 ± 0.25
Epithalamus6.72 ± 0.39
Frontal Lobe7.2 ± 0.33
Globus Pallidus6.54 ± 0.22
Hypothalamus6.99 ± 0.4
Insula7.31 ± 0.35
Limbic Lobe7.38 ± 0.3
Mesencephalon7.23 ± 0.38
Myelencephalon7.18 ± 0.35
Occipital Lobe7.33 ± 0.24
Parietal Lobe7.41 ± 0.29
Pontine Tegmentum7.15 ± 0.24
Striatum6.74 ± 0.36
Subthalamus7.07 ± 0.46
Temporal Lobe7.43 ± 0.25
Thalamus7.15 ± 0.29
White Matter6.67 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Polr3aCBCerebellum7.96
8.25
Polr3aCTXCerebral cortex10.26
7.59
Polr3aHIPHippocampal region9.58
8.68
Polr3aHPFHippocampal formation9.48
7.77
Polr3aHYHypothalamus1.62
1.11
Polr3aLSXLateral septal complex0.48
0.55
Polr3aMBMidbrain3.95
3.52
Polr3aMYMedulla9.23
9.58
Polr3aOLFOlfactory bulb13.52
9.57
Polr3aPPons6.63
6.56
Polr3aPALPallidum3.28
2.28
Polr3aRHPRetrohippocampal region9.46
6.4
Polr3asAMYStriatum-like amygdalar nuclei1.94
1.41
Polr3aSTRStriatum2.71
1.97
Polr3aSTRdStriatum dorsal region2.95
2.21
Polr3aSTRvStriatum ventral region3.37
2.12
Polr3aTHThalamus2.61
1.98
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00063481 21 1079 1099 AISTPIITAQLDKDDDADYAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018