AutismKB 2.0

Annotation Detail for CHGB


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Basic Information Top
Gene Symbol:CHGB ( SCG1 )
Gene Full Name: chromogranin B (secretogranin 1)
Band: 20p12.3
Quick LinksEntrez ID:1114; OMIM: 118920; Uniprot ID:SCG1_HUMAN; ENSEMBL ID: ENSG00000089199; HGNC ID: 1930
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus41 / 56401272
neonate0 / 310970 
infant1 / 2362042
juvenile7 / 55556125
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor30 / 127942344
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor27 / 263845102
glioma4 / 10688337
head and neck tumor5 / 13630236
kidney tumor14 / 68959203
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor9 / 10312787
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal480 / 3360307142
ovarian tumor0 / 766820 
pancreatic tumor73 / 104616697
primitive neuroectodermal tumor of the CNS53 / 125680421
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland65 / 331971958
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain302 / 1100989274
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine3 / 23447212
kidney14 / 21177766
larynx0 / 241450 
liver0 / 2077430 
lung20 / 33697459
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth4 / 6705259
muscle4 / 10771537
nerve5 / 15768317
ovary0 / 1020510 
pancreas168 / 214812782
parathyroid5 / 20539243
pharynx0 / 413280 
pituitary gland43 / 165852592
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis14 / 33044242
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204260_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.7
Adipocyte8.3
AdrenalCortex1826.05
Adrenalgland1653
Amygdala635.2
Appendix10.95
AtrioventricularNode7.95
BDCA4+_DentriticCells8.7
Bonemarrow19.45
BronchialEpithelialCells9
CD105+_Endothelial8.35
CD14+_Monocytes9.75
CD19+_BCells(neg._sel.)8.9
CD33+_Myeloid11.35
CD34+11.3
CD4+_Tcells8.7
CD56+_NKCells9.4
CD71+_EarlyErythroid8.1
CD8+_Tcells7.65
CardiacMyocytes13
Caudatenucleus54.35
Cerebellum1887.95
CerebellumPeduncles2500.95
CiliaryGanglion6.95
CingulateCortex173.2
Colorectaladenocarcinoma9.1
DorsalRootGanglion9.15
FetalThyroid9.75
Fetalbrain291.75
Fetalliver7.5
Fetallung6.6
GlobusPallidus126.2
Heart12.6
Hypothalamus762.1
Kidney8.05
Leukemia_chronicMyelogenousK-5628.1
Leukemia_promyelocytic-HL-607.5
Leukemialymphoblastic(MOLT-4)6.55
Liver13.25
Lung9.65
Lymphnode7.95
Lymphoma_burkitts(Daudi)12.6
Lymphoma_burkitts(Raji)13.8
MedullaOblongata92.15
OccipitalLobe183.1
OlfactoryBulb6.65
Ovary6.1
Pancreas40.15
PancreaticIslet2685.65
ParietalLobe227.4
Pituitary10635.5
Placenta8.45
Pons116.9
PrefrontalCortex281.4
Prostate11.35
Salivarygland7.85
SkeletalMuscle11.35
Skin7.85
SmoothMuscle11.35
Spinalcord50.7
SubthalamicNucleus86.95
SuperiorCervicalGanglion11.2
TemporalLobe167.9
Testis11.95
TestisGermCell8.55
TestisIntersitial11.7
TestisLeydigCell10.05
TestisSeminiferousTubule8.1
Thalamus168
Thymus7.9
Thyroid12.2
Tongue9.9
Tonsil11.45
Trachea8.15
TrigeminalGanglion9.85
Uterus7.2
UterusCorpus8.3
WholeBlood9.35
Wholebrain444.8
colon11.35
pineal_day3889.72
pineal_night4100.2
retina29.875
small_intestine13.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P57155
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.28 ± 0.64
Basal Forebrain8.89 ± 0.46
Basal Part of Pons10.77 ± 0.18
Cerebellar Cortex10.51 ± 0.35
Cerebellar Nuclei8.37 ± 0.42
Claustrum9.82 ± 0.77
Epithalamus7.89 ± 0.72
Frontal Lobe9.35 ± 0.53
Globus Pallidus6.95 ± 1.05
Hypothalamus9.7 ± 0.95
Insula9.68 ± 0.27
Limbic Lobe10.2 ± 0.9
Mesencephalon9.18 ± 0.93
Myelencephalon9.38 ± 1.09
Occipital Lobe10.15 ± 0.9
Parietal Lobe9.32 ± 0.48
Pontine Tegmentum9.04 ± 1.08
Striatum7.68 ± 0.81
Subthalamus8.61 ± 0.28
Temporal Lobe9.75 ± 0.43
Thalamus8.82 ± 0.54
White Matter5.9 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ChgbCBCerebellum100
100
ChgbCTXCerebral cortex100
100
ChgbHIPHippocampal region100
100
ChgbHPFHippocampal formation100
100
ChgbHYHypothalamus100
100
ChgbLSXLateral septal complex100
100
ChgbMBMidbrain100
100
ChgbMYMedulla100
100
ChgbOLFOlfactory bulb100
100
ChgbPPons100
100
ChgbPALPallidum100
100
ChgbRHPRetrohippocampal region100
100
ChgbsAMYStriatum-like amygdalar nuclei100
100
ChgbSTRStriatum100
100
ChgbSTRdStriatum dorsal region100
100
ChgbSTRvStriatum ventral region100
100
ChgbTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064467 12 36 47 CIIEVLSNALSK Peptide Atlas
SCG1_HUMAN_15 12 15 26 LAAVNSMPVDNR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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