AutismKB 2.0

Annotation Detail for WDR45


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Basic Information Top
Gene Symbol:WDR45 ( WDRX1,WIPI-4,WIPI4 )
Gene Full Name: WD repeat domain 45
Band: Xp11.23
Quick LinksEntrez ID:11152; OMIM: 300526; Uniprot ID:WIPI4_HUMAN; ENSEMBL ID: ENSG00000196998; HGNC ID: 28912
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult150 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor6 / 34366174
chondrosarcoma12 / 82823144
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor14 / 26384553
glioma2 / 10688318
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor3 / 9635931
lung tumor11 / 103127106
lymphoma3 / 7175541
non-neoplasia7 / 9725071
normal230 / 336030768
ovarian tumor7 / 7668291
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites1 / 4001524
bladder2 / 2975767
blood8 / 12347864
bone8 / 71655111
bone marrow1 / 4880120
brain90 / 110098981
cervix6 / 48171124
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye21 / 21105499
heart5 / 8962655
intestine27 / 234472115
kidney10 / 21177747
larynx3 / 24145124
liver16 / 20774377
lung35 / 336974103
lymph1 / 4427022
lymph node2 / 9161021
mammary gland4 / 15327126
mouth2 / 6705229
muscle2 / 10771518
nerve1 / 1576863
ovary8 / 10205178
pancreas8 / 21481237
parathyroid6 / 20539292
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta25 / 28082589
prostate11 / 18934558
salivary gland2 / 2015599
skin7 / 21057433
spleen5 / 5395292
stomach9 / 9661993
testis8 / 33044224
thymus9 / 81131110
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus21 / 23287890
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209216_at
Cell line Expression level Expression bar
721_B_lymphoblasts75.15
Adipocyte104.25
AdrenalCortex66.5
Adrenalgland154.95
Amygdala91.75
Appendix47.4
AtrioventricularNode35.55
BDCA4+_DentriticCells407.35
Bonemarrow78.4
BronchialEpithelialCells99.05
CD105+_Endothelial85.85
CD14+_Monocytes334.2
CD19+_BCells(neg._sel.)206.9
CD33+_Myeloid243.45
CD34+100.4
CD4+_Tcells179.25
CD56+_NKCells480.25
CD71+_EarlyErythroid542.85
CD8+_Tcells167.85
CardiacMyocytes76.4
Caudatenucleus74.2
Cerebellum48.15
CerebellumPeduncles60.45
CiliaryGanglion30.45
CingulateCortex89.4
Colorectaladenocarcinoma252.9
DorsalRootGanglion32.9
FetalThyroid90.7
Fetalbrain56.4
Fetalliver38.05
Fetallung86.7
GlobusPallidus53.9
Heart371
Hypothalamus80
Kidney99.65
Leukemia_chronicMyelogenousK-56245.5
Leukemia_promyelocytic-HL-6054.15
Leukemialymphoblastic(MOLT-4)39.55
Liver300.1
Lung166.55
Lymphnode96.5
Lymphoma_burkitts(Daudi)66.55
Lymphoma_burkitts(Raji)99.8
MedullaOblongata57.75
OccipitalLobe66.75
OlfactoryBulb42.7
Ovary59.85
Pancreas47.35
PancreaticIslet120.85
ParietalLobe70.3
Pituitary61.15
Placenta316.3
Pons44.95
PrefrontalCortex114.75
Prostate173.65
Salivarygland67.8
SkeletalMuscle52.75
Skin28.05
SmoothMuscle81.85
Spinalcord60.05
SubthalamicNucleus60
SuperiorCervicalGanglion30.9
TemporalLobe78.2
Testis19.9
TestisGermCell26.4
TestisIntersitial16.8
TestisLeydigCell53.2
TestisSeminiferousTubule25.15
Thalamus111.45
Thymus135.2
Thyroid297.35
Tongue46.9
Tonsil54.1
Trachea66.7
TrigeminalGanglion23.25
Uterus131.9
UterusCorpus57.85
WholeBlood246.8
Wholebrain225.95
colon37.65
pineal_day187.42
pineal_night137.82
retina199.575
small_intestine51.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_210_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.41 ± 0.37
Basal Forebrain6.47 ± 0.41
Basal Part of Pons6.57 ± 0.46
Cerebellar Cortex6.11 ± 0.39
Cerebellar Nuclei6.71 ± 0.39
Claustrum7.06 ± 0.67
Epithalamus6.05 ± 0.6
Frontal Lobe6.29 ± 0.49
Globus Pallidus6.93 ± 0.24
Hypothalamus6.1 ± 0.64
Insula6.1 ± 0.36
Limbic Lobe6.57 ± 0.56
Mesencephalon6.49 ± 0.59
Myelencephalon6.49 ± 0.43
Occipital Lobe6.84 ± 0.58
Parietal Lobe6.45 ± 0.43
Pontine Tegmentum6.37 ± 0.5
Striatum6.77 ± 0.54
Subthalamus5.92 ± 0.72
Temporal Lobe6.28 ± 0.43
Thalamus6.59 ± 0.39
White Matter6.87 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr45CBCerebellum0.96
1.44
Wdr45CTXCerebral cortex3.88
2.12
Wdr45HIPHippocampal region1.71
1.75
Wdr45HPFHippocampal formation1.31
1.24
Wdr45HYHypothalamus0.95
0.64
Wdr45LSXLateral septal complex0.92
0.74
Wdr45MBMidbrain1.71
1.44
Wdr45MYMedulla6.03
4.51
Wdr45OLFOlfactory bulb0.93
0.63
Wdr45PPons3.3
2.35
Wdr45PALPallidum0.95
1.15
Wdr45RHPRetrohippocampal region0.6
0.45
Wdr45sAMYStriatum-like amygdalar nuclei0.18
0.15
Wdr45STRStriatum0.34
0.25
Wdr45STRdStriatum dorsal region0.29
0.22
Wdr45STRvStriatum ventral region0.3
0.18
Wdr45THThalamus2.3
1.47
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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