AutismKB 2.0

Annotation Detail for CHI3L2


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Basic Information Top
Gene Symbol:CHI3L2 ( YKL-39,YKL39 )
Gene Full Name: chitinase 3-like 2
Band: 1p13.2
Quick LinksEntrez ID:1117; OMIM: 601526; Uniprot ID:CH3L2_HUMAN; ENSEMBL ID: ENSG00000064886; HGNC ID: 1933
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile21 / 55556377
adult141 / 193912172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor19 / 119369159
germ cell tumor5 / 26384518
glioma14 / 106883130
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia28 / 95842292
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma22 / 71755306
non-neoplasia66 / 97250678
normal124 / 336030736
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites18 / 40015449
bladder0 / 297570 
blood26 / 123478210
bone9 / 71655125
bone marrow0 / 488010 
brain22 / 110098919
cervix0 / 481710 
connective tissue75 / 149255502
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye11 / 21105452
heart1 / 8962611
intestine0 / 2344720 
kidney1 / 2117774
larynx1 / 2414541
liver0 / 2077430 
lung31 / 33697491
lymph18 / 44270406
lymph node9 / 9161098
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta13 / 28082546
prostate0 / 1893450 
salivary gland2 / 2015599
skin7 / 21057433
spleen1 / 5395218
stomach2 / 9661920
testis2 / 3304426
thymus18 / 81131221
thyroid1 / 4747321
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213060_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.8
Adipocyte741.9
AdrenalCortex6.6
Adrenalgland5.5
Amygdala6.4
Appendix6.75
AtrioventricularNode5.8
BDCA4+_DentriticCells6.65
Bonemarrow6.55
BronchialEpithelialCells6.05
CD105+_Endothelial6.25
CD14+_Monocytes6.15
CD19+_BCells(neg._sel.)6.2
CD33+_Myeloid7.7
CD34+6.65
CD4+_Tcells17.95
CD56+_NKCells7.7
CD71+_EarlyErythroid5.75
CD8+_Tcells6.3
CardiacMyocytes9
Caudatenucleus6.1
Cerebellum5.15
CerebellumPeduncles7.25
CiliaryGanglion8.3
CingulateCortex6.55
Colorectaladenocarcinoma6.25
DorsalRootGanglion9
FetalThyroid6.2
Fetalbrain11.1
Fetalliver8
Fetallung8.35
GlobusPallidus4.55
Heart8.85
Hypothalamus6.65
Kidney9.1
Leukemia_chronicMyelogenousK-5625.8
Leukemia_promyelocytic-HL-60896.6
Leukemialymphoblastic(MOLT-4)783.65
Liver17.4
Lung11.9
Lymphnode6.75
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)776.1
MedullaOblongata5.6
OccipitalLobe5.45
OlfactoryBulb5.6
Ovary4.25
Pancreas5
PancreaticIslet6.7
ParietalLobe6.4
Pituitary7.3
Placenta6.35
Pons6.05
PrefrontalCortex7.6
Prostate6.8
Salivarygland44.3
SkeletalMuscle7.45
Skin5.9
SmoothMuscle7.05
Spinalcord22.8
SubthalamicNucleus5.75
SuperiorCervicalGanglion7.8
TemporalLobe5.5
Testis5.05
TestisGermCell4.7
TestisIntersitial5.05
TestisLeydigCell6.2
TestisSeminiferousTubule5.1
Thalamus6.2
Thymus214.45
Thyroid7.75
Tongue6.5
Tonsil21.15
Trachea5.2
TrigeminalGanglion7.6
Uterus5
UterusCorpus5.75
WholeBlood7.15
Wholebrain4.65
colon5.7
pineal_day7.54
pineal_night6.78
retina18.775
small_intestine5.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10263_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.16 ± 1.02
Basal Forebrain1.76 ± 0.27
Basal Part of Pons1.9 ± 0.81
Cerebellar Cortex1.49 ± 0.39
Cerebellar Nuclei1.96 ± 0.73
Claustrum2.58 ± 0.83
Epithalamus2.43 ± 1.02
Frontal Lobe1.61 ± 0.71
Globus Pallidus3.89 ± 0.77
Hypothalamus1.89 ± 0.79
Insula1.56 ± 0.48
Limbic Lobe1.72 ± 0.69
Mesencephalon1.95 ± 0.77
Myelencephalon1.78 ± 0.68
Occipital Lobe1.91 ± 0.99
Parietal Lobe1.88 ± 0.89
Pontine Tegmentum1.78 ± 0.82
Striatum1.97 ± 0.53
Subthalamus1.85 ± 0.7
Temporal Lobe1.66 ± 0.71
Thalamus1.75 ± 0.63
White Matter2.6 ± 1.11
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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