AutismKB 2.0

Annotation Detail for MAP4K5


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Basic Information Top
Gene Symbol:MAP4K5 ( GCKR,KHS,KHS1,MAPKKKK5 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 5
Band: 14q22.1
Quick LinksEntrez ID:11183; OMIM: 604923; Uniprot ID:M4K5_HUMAN; ENSEMBL ID: ENSG00000012983; HGNC ID: 6867
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus16 / 56401228
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult72 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor7 / 26384526
glioma2 / 10688318
head and neck tumor9 / 13630266
kidney tumor1 / 6895914
leukemia8 / 9584283
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal117 / 336030734
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood8 / 12347864
bone5 / 7165569
bone marrow0 / 488010 
brain49 / 110098944
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine7 / 23447229
kidney6 / 21177728
larynx1 / 2414541
liver1 / 2077434
lung10 / 33697429
lymph0 / 442700 
lymph node6 / 9161065
mammary gland6 / 15327139
mouth5 / 6705274
muscle3 / 10771527
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta11 / 28082539
prostate3 / 18934515
salivary gland0 / 201550 
skin11 / 21057452
spleen0 / 539520 
stomach6 / 9661962
testis8 / 33044224
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord2 / 13680146
uterus20 / 23287885
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203553_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts27.3
Adipocyte7.4
AdrenalCortex7.9
Adrenalgland6.4
Amygdala11.95
Appendix9.1
AtrioventricularNode8.55
BDCA4+_DentriticCells12.45
Bonemarrow7.6
BronchialEpithelialCells7.3
CD105+_Endothelial11.3
CD14+_Monocytes7.4
CD19+_BCells(neg._sel.)14.45
CD33+_Myeloid9.95
CD34+26.25
CD4+_Tcells9.9
CD56+_NKCells9.05
CD71+_EarlyErythroid74.5
CD8+_Tcells14.3
CardiacMyocytes18.75
Caudatenucleus6.7
Cerebellum5.7
CerebellumPeduncles8.4
CiliaryGanglion5.95
CingulateCortex8.35
Colorectaladenocarcinoma7.35
DorsalRootGanglion7.3
FetalThyroid7.25
Fetalbrain14.35
Fetalliver6.8
Fetallung7.65
GlobusPallidus5.8
Heart10
Hypothalamus20.55
Kidney6
Leukemia_chronicMyelogenousK-5626.85
Leukemia_promyelocytic-HL-606.5
Leukemialymphoblastic(MOLT-4)5.7
Liver9.9
Lung7.25
Lymphnode6.05
Lymphoma_burkitts(Daudi)10.1
Lymphoma_burkitts(Raji)11.3
MedullaOblongata12.25
OccipitalLobe15.4
OlfactoryBulb9.1
Ovary5.55
Pancreas5.9
PancreaticIslet8.15
ParietalLobe16.1
Pituitary8.15
Placenta6.65
Pons7.95
PrefrontalCortex17.55
Prostate8.2
Salivarygland15.7
SkeletalMuscle10.6
Skin7.35
SmoothMuscle29.4
Spinalcord8
SubthalamicNucleus6.8
SuperiorCervicalGanglion13.95
TemporalLobe6.8
Testis5.7
TestisGermCell6
TestisIntersitial6.25
TestisLeydigCell8.35
TestisSeminiferousTubule6.2
Thalamus7.55
Thymus5
Thyroid8.6
Tongue7.9
Tonsil7.4
Trachea6.3
TrigeminalGanglion13.15
Uterus16.4
UterusCorpus10.65
WholeBlood7.4
Wholebrain5.6
colon7.6
pineal_day10.7
pineal_night10.98
retina9.6
small_intestine6.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P16997
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.53 ± 0.44
Basal Forebrain8.1 ± 0.17
Basal Part of Pons7.68 ± 0.31
Cerebellar Cortex7.87 ± 0.15
Cerebellar Nuclei8.06 ± 0.41
Claustrum7.35 ± 0.28
Epithalamus7.85 ± 0.36
Frontal Lobe7.79 ± 0.4
Globus Pallidus8.68 ± 0.22
Hypothalamus7.78 ± 0.19
Insula7.72 ± 0.14
Limbic Lobe7.68 ± 0.31
Mesencephalon7.86 ± 0.4
Myelencephalon7.8 ± 0.41
Occipital Lobe7.77 ± 0.25
Parietal Lobe7.76 ± 0.33
Pontine Tegmentum7.9 ± 0.32
Striatum7.93 ± 0.44
Subthalamus7.88 ± 0.08
Temporal Lobe7.73 ± 0.27
Thalamus7.98 ± 0.33
White Matter9.51 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map4k5CBCerebellum13.57
13.91
Map4k5CTXCerebral cortex43.82
29.91
Map4k5HIPHippocampal region30.99
41.66
Map4k5HPFHippocampal formation28.03
31.71
Map4k5HYHypothalamus9.86
6.67
Map4k5LSXLateral septal complex14.55
10.24
Map4k5MBMidbrain19.3
16.33
Map4k5MYMedulla33.12
31.31
Map4k5OLFOlfactory bulb44.03
32.29
Map4k5PPons21.81
20.01
Map4k5PALPallidum10.97
7.69
Map4k5RHPRetrohippocampal region23.49
18.47
Map4k5sAMYStriatum-like amygdalar nuclei16.11
10.07
Map4k5STRStriatum17.92
11.47
Map4k5STRdStriatum dorsal region16.06
10.55
Map4k5STRvStriatum ventral region26.47
15.24
Map4k5THThalamus13.09
10.27
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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