AutismKB 2.0

Annotation Detail for MAP4K1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP4K1 ( HPK1 )
Gene Full Name: mitogen-activated protein kinase kinase kinase kinase 1
Band: 19q13.1-q13.4
Quick LinksEntrez ID:11184; OMIM: 601983; Uniprot ID:M4K1_HUMAN; ENSEMBL ID: ENSG00000104814; HGNC ID: 6863
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult26 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma17 / 71755236
non-neoplasia0 / 972500 
normal59 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood8 / 12347864
bone1 / 7165513
bone marrow2 / 4880140
brain5 / 11009894
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx2 / 2414582
liver0 / 2077430 
lung2 / 3369745
lymph6 / 44270135
lymph node15 / 91610163
mammary gland1 / 1532716
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen3 / 5395255
stomach1 / 9661910
testis0 / 3304420 
thymus7 / 8113186
thyroid0 / 474730 
tonsil7 / 16999411
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206296_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts522.95
Adipocyte4.5
AdrenalCortex4.8
Adrenalgland3.9
Amygdala4.9
Appendix4.65
AtrioventricularNode3.55
BDCA4+_DentriticCells247.9
Bonemarrow6.35
BronchialEpithelialCells4.6
CD105+_Endothelial4.75
CD14+_Monocytes34.25
CD19+_BCells(neg._sel.)310.85
CD33+_Myeloid59.55
CD34+13.95
CD4+_Tcells140.95
CD56+_NKCells59.2
CD71+_EarlyErythroid4.35
CD8+_Tcells133.9
CardiacMyocytes5.75
Caudatenucleus4.15
Cerebellum3.75
CerebellumPeduncles5.25
CiliaryGanglion3.25
CingulateCortex4.7
Colorectaladenocarcinoma4.65
DorsalRootGanglion3.5
FetalThyroid4.5
Fetalbrain4.65
Fetalliver4.05
Fetallung3.85
GlobusPallidus3.35
Heart7.45
Hypothalamus5.1
Kidney3.7
Leukemia_chronicMyelogenousK-5624.2
Leukemia_promyelocytic-HL-6051.2
Leukemialymphoblastic(MOLT-4)17
Liver6.1
Lung5.75
Lymphnode45.05
Lymphoma_burkitts(Daudi)49.9
Lymphoma_burkitts(Raji)460.05
MedullaOblongata4.25
OccipitalLobe4.1
OlfactoryBulb3.65
Ovary3.05
Pancreas3.75
PancreaticIslet4.95
ParietalLobe4.9
Pituitary5.4
Placenta4.85
Pons4.4
PrefrontalCortex5.7
Prostate5.45
Salivarygland3.9
SkeletalMuscle8.15
Skin3.55
SmoothMuscle5.2
Spinalcord4.95
SubthalamicNucleus4.2
SuperiorCervicalGanglion5.2
TemporalLobe4.2
Testis4
TestisGermCell3.8
TestisIntersitial3.9
TestisLeydigCell4.55
TestisSeminiferousTubule3.9
Thalamus4.7
Thymus15.8
Thyroid5.85
Tongue4.5
Tonsil37
Trachea3.85
TrigeminalGanglion4.6
Uterus3.85
UterusCorpus4.15
WholeBlood17.2
Wholebrain3.95
colon4.65
pineal_day7.12
pineal_night6.24
retina9.675
small_intestine4.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13376_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.84 ± 1.07
Basal Forebrain2.37 ± 0.3
Basal Part of Pons2.28 ± 0.67
Cerebellar Cortex2.24 ± 0.73
Cerebellar Nuclei2.75 ± 0.65
Claustrum3.31 ± 1.01
Epithalamus2.09 ± 0.91
Frontal Lobe2.37 ± 0.84
Globus Pallidus3.2 ± 0.66
Hypothalamus2.29 ± 0.73
Insula2.1 ± 0.62
Limbic Lobe2.61 ± 0.92
Mesencephalon2.49 ± 0.79
Myelencephalon2.45 ± 0.76
Occipital Lobe2.5 ± 0.78
Parietal Lobe2.4 ± 0.94
Pontine Tegmentum2.72 ± 0.96
Striatum2.61 ± 0.77
Subthalamus2.46 ± 0.77
Temporal Lobe2.37 ± 0.85
Thalamus2.32 ± 0.77
White Matter3.07 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map4k1CBCerebellum11.28
14.91
Map4k1CTXCerebral cortex13.83
10.3
Map4k1HIPHippocampal region4.87
4.64
Map4k1HPFHippocampal formation4.51
3.96
Map4k1HYHypothalamus1.84
1.31
Map4k1LSXLateral septal complex1.39
1.2
Map4k1MBMidbrain2.72
3.16
Map4k1MYMedulla2.48
3.41
Map4k1OLFOlfactory bulb19.21
19
Map4k1PPons3.88
4.9
Map4k1PALPallidum2.22
2.26
Map4k1RHPRetrohippocampal region3.88
3.04
Map4k1sAMYStriatum-like amygdalar nuclei5.07
3.61
Map4k1STRStriatum3.89
2.98
Map4k1STRdStriatum dorsal region3.47
2.44
Map4k1STRvStriatum ventral region5.5
4.87
Map4k1THThalamus2.66
2.29
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved