AutismKB 2.0

Annotation Detail for NISCH


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Basic Information Top
Gene Symbol:NISCH ( FLJ14425,FLJ40413,FLJ90519,I-1,IRAS,KIAA0975 )
Gene Full Name: nischarin
Band: 3p21.1
Quick LinksEntrez ID:11188; OMIM: NA; Uniprot ID:NISCH_HUMAN; ENSEMBL ID: ENSG00000010322; HGNC ID: 18006
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst15 / 62319240
fetus64 / 564012113
neonate0 / 310970 
infant2 / 2362084
juvenile5 / 5555689
adult256 / 1939121132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor12 / 114246105
esophageal tumor0 / 172900 
gastrointestinal tumor21 / 119369175
germ cell tumor35 / 263845132
glioma13 / 106883121
head and neck tumor13 / 13630295
kidney tumor7 / 68959101
leukemia13 / 95842135
liver tumor3 / 9635931
lung tumor7 / 10312767
lymphoma31 / 71755432
non-neoplasia9 / 9725092
normal477 / 3360307141
ovarian tumor15 / 76682195
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer38 / 102680370
retinoblastoma9 / 46356194
skin tumor2 / 12494916
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland1 / 3319730
ascites3 / 4001574
bladder1 / 2975733
blood11 / 12347889
bone7 / 7165597
bone marrow3 / 4880161
brain249 / 1100989226
cervix4 / 4817183
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue29 / 215722134
esophagus0 / 202090 
eye30 / 211054142
heart5 / 8962655
intestine23 / 23447298
kidney14 / 21177766
larynx3 / 24145124
liver7 / 20774333
lung39 / 336974115
lymph27 / 44270609
lymph node3 / 9161032
mammary gland11 / 15327171
mouth5 / 6705274
muscle9 / 10771583
nerve4 / 15768253
ovary19 / 102051186
pancreas18 / 21481283
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta15 / 28082553
prostate50 / 189345264
salivary gland0 / 201550 
skin10 / 21057447
spleen7 / 53952129
stomach18 / 96619186
testis93 / 330442281
thymus19 / 81131234
thyroid8 / 47473168
tonsil4 / 16999235
trachea9 / 52413171
umbilical cord0 / 136800 
uterus32 / 232878137
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201591_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts135.35
Adipocyte62.05
AdrenalCortex138.8
Adrenalgland194.3
Amygdala862.15
Appendix63.35
AtrioventricularNode52.1
BDCA4+_DentriticCells364.8
Bonemarrow123.65
BronchialEpithelialCells83.65
CD105+_Endothelial160.7
CD14+_Monocytes311.8
CD19+_BCells(neg._sel.)353.5
CD33+_Myeloid600.25
CD34+407.8
CD4+_Tcells432.8
CD56+_NKCells317.5
CD71+_EarlyErythroid44.9
CD8+_Tcells549.15
CardiacMyocytes55.45
Caudatenucleus281.45
Cerebellum485.8
CerebellumPeduncles444.8
CiliaryGanglion77.85
CingulateCortex279.7
Colorectaladenocarcinoma143
DorsalRootGanglion54.4
FetalThyroid206.85
Fetalbrain461.05
Fetalliver78.85
Fetallung253.15
GlobusPallidus206.8
Heart153.6
Hypothalamus768.65
Kidney89.75
Leukemia_chronicMyelogenousK-562109.75
Leukemia_promyelocytic-HL-60106.6
Leukemialymphoblastic(MOLT-4)151.05
Liver122.6
Lung420.3
Lymphnode245.65
Lymphoma_burkitts(Daudi)142.25
Lymphoma_burkitts(Raji)231.1
MedullaOblongata251.95
OccipitalLobe352.95
OlfactoryBulb225.8
Ovary55.1
Pancreas91.85
PancreaticIslet174.55
ParietalLobe328.45
Pituitary636.2
Placenta153.6
Pons181.95
PrefrontalCortex952.6
Prostate846
Salivarygland125.65
SkeletalMuscle9.75
Skin86.75
SmoothMuscle127.75
Spinalcord298.5
SubthalamicNucleus273.95
SuperiorCervicalGanglion44.35
TemporalLobe222.85
Testis679.05
TestisGermCell459.1
TestisIntersitial270.25
TestisLeydigCell195.25
TestisSeminiferousTubule242.4
Thalamus296.45
Thymus268.8
Thyroid471.05
Tongue79.5
Tonsil110.95
Trachea142.85
TrigeminalGanglion15.8
Uterus408.55
UterusCorpus148.45
WholeBlood110.55
Wholebrain676.45
colon29.8
pineal_day652.08
pineal_night933.66
retina414.95
small_intestine31.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6787_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.93 ± 0.4
Basal Forebrain4.67 ± 0.28
Basal Part of Pons4.88 ± 0.63
Cerebellar Cortex5.31 ± 0.58
Cerebellar Nuclei4.03 ± 0.65
Claustrum5.19 ± 0.65
Epithalamus4.83 ± 0.52
Frontal Lobe4.94 ± 0.64
Globus Pallidus3.53 ± 0.56
Hypothalamus4.85 ± 0.61
Insula5.1 ± 0.44
Limbic Lobe4.97 ± 0.63
Mesencephalon4.72 ± 0.58
Myelencephalon4.8 ± 0.68
Occipital Lobe4.55 ± 0.59
Parietal Lobe4.65 ± 0.63
Pontine Tegmentum4.79 ± 0.65
Striatum4.23 ± 0.48
Subthalamus4.56 ± 0.24
Temporal Lobe5.12 ± 0.53
Thalamus4.73 ± 0.57
White Matter3.79 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
NischCBCerebellum50.51
75.69
NischCTXCerebral cortex100
100
NischHIPHippocampal region100
100
NischHPFHippocampal formation100
100
NischHYHypothalamus57.43
60.37
NischLSXLateral septal complex36.5
35.56
NischMBMidbrain88.39
92.82
NischMYMedulla62.24
69.23
NischOLFOlfactory bulb100
100
NischPPons65.38
75.66
NischPALPallidum79.37
90.31
NischRHPRetrohippocampal region100
100
NischsAMYStriatum-like amygdalar nuclei100
100
NischSTRStriatum100
100
NischSTRdStriatum dorsal region100
100
NischSTRvStriatum ventral region100
100
NischTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00096891 25 397 421 SIGSLPCLEHVSLLNNPLSIIPDYR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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