AutismKB 2.0

Annotation Detail for CHKA


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Basic Information Top
Gene Symbol:CHKA ( CHK,CK,CKI,EK )
Gene Full Name: choline kinase alpha
Band: 11q13.2
Quick LinksEntrez ID:1119; OMIM: 118491; Uniprot ID:CHKA_HUMAN; ENSEMBL ID: ENSG00000110721; HGNC ID: 1937
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst5 / 6231980
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult85 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor20 / 114246175
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia7 / 9584273
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal127 / 336030737
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor6 / 12494948
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood7 / 12347856
bone2 / 7165527
bone marrow0 / 488010 
brain32 / 110098929
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye10 / 21105447
heart6 / 8962666
intestine24 / 234472102
kidney3 / 21177714
larynx1 / 2414541
liver1 / 2077434
lung8 / 33697423
lymph1 / 4427022
lymph node8 / 9161087
mammary gland8 / 15327152
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate4 / 18934521
salivary gland1 / 2015549
skin6 / 21057428
spleen2 / 5395237
stomach3 / 9661931
testis30 / 33044290
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204233_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts28.1
Adipocyte19
AdrenalCortex22.35
Adrenalgland14.5
Amygdala19.1
Appendix16.8
AtrioventricularNode13.3
BDCA4+_DentriticCells18
Bonemarrow16.65
BronchialEpithelialCells11.9
CD105+_Endothelial16.1
CD14+_Monocytes15.45
CD19+_BCells(neg._sel.)15.2
CD33+_Myeloid21.05
CD34+22.55
CD4+_Tcells15.15
CD56+_NKCells14.2
CD71+_EarlyErythroid17.35
CD8+_Tcells14.05
CardiacMyocytes27.25
Caudatenucleus15.6
Cerebellum13.5
CerebellumPeduncles18.95
CiliaryGanglion12.2
CingulateCortex17.15
Colorectaladenocarcinoma32.55
DorsalRootGanglion13.4
FetalThyroid15.55
Fetalbrain15.2
Fetalliver14.4
Fetallung13.65
GlobusPallidus15.95
Heart20.9
Hypothalamus23.05
Kidney17.4
Leukemia_chronicMyelogenousK-56215.1
Leukemia_promyelocytic-HL-6018.9
Leukemialymphoblastic(MOLT-4)13.65
Liver22.35
Lung18.05
Lymphnode14.05
Lymphoma_burkitts(Daudi)21.7
Lymphoma_burkitts(Raji)24.3
MedullaOblongata15.5
OccipitalLobe26.8
OlfactoryBulb13.65
Ovary11.15
Pancreas16.9
PancreaticIslet18
ParietalLobe32
Pituitary19.4
Placenta15.55
Pons17.95
PrefrontalCortex39.45
Prostate19.6
Salivarygland16.65
SkeletalMuscle20.7
Skin15.55
SmoothMuscle15.45
Spinalcord24.15
SubthalamicNucleus29.8
SuperiorCervicalGanglion19.65
TemporalLobe15.3
Testis356.6
TestisGermCell355.95
TestisIntersitial373.6
TestisLeydigCell220.35
TestisSeminiferousTubule175.35
Thalamus18.05
Thymus11.05
Thyroid25.7
Tongue16.6
Tonsil13.75
Trachea13.9
TrigeminalGanglion16.35
Uterus9.5
UterusCorpus15.2
WholeBlood16.7
Wholebrain16.95
colon16.75
pineal_day22.8
pineal_night19.74
retina32.45
small_intestine16.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P136135
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.81 ± 0.43
Basal Forebrain5.24 ± 0.22
Basal Part of Pons5.26 ± 0.2
Cerebellar Cortex4.58 ± 0.27
Cerebellar Nuclei5.05 ± 0.6
Claustrum4.83 ± 0.54
Epithalamus5.07 ± 0.48
Frontal Lobe4.85 ± 0.43
Globus Pallidus5.43 ± 0.32
Hypothalamus4.68 ± 0.39
Insula4.69 ± 0.28
Limbic Lobe4.8 ± 0.5
Mesencephalon4.93 ± 0.51
Myelencephalon4.9 ± 0.47
Occipital Lobe5.07 ± 0.44
Parietal Lobe4.92 ± 0.32
Pontine Tegmentum4.9 ± 0.42
Striatum5.23 ± 0.36
Subthalamus4.68 ± 0.55
Temporal Lobe4.87 ± 0.4
Thalamus5.08 ± 0.37
White Matter6.21 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ChkaCBCerebellum3.76
2.84
ChkaCTXCerebral cortex48.9
15.14
ChkaHIPHippocampal region32.81
19.54
ChkaHPFHippocampal formation33.36
15.31
ChkaHYHypothalamus5.64
1.42
ChkaLSXLateral septal complex37.36
9.06
ChkaMBMidbrain6.29
2.61
ChkaMYMedulla14.97
6.96
ChkaOLFOlfactory bulb34.97
10.56
ChkaPPons13.75
5.8
ChkaPALPallidum6.83
1.93
ChkaRHPRetrohippocampal region35.41
10.27
ChkasAMYStriatum-like amygdalar nuclei14.23
3.07
ChkaSTRStriatum12.28
3.17
ChkaSTRdStriatum dorsal region11.25
3.17
ChkaSTRvStriatum ventral region11.06
2.42
ChkaTHThalamus21.34
7.74
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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