AutismKB 2.0

Annotation Detail for WBP4


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Basic Information Top
Gene Symbol:WBP4 ( FBP21,MGC117310 )
Gene Full Name: WW domain binding protein 4 (formin binding protein 21)
Band: 13q14.11
Quick LinksEntrez ID:11193; OMIM: 604981; Uniprot ID:WBP4_HUMAN; ENSEMBL ID: ENSG00000120688; HGNC ID: 12739
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus26 / 56401246
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult58 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor3 / 3436687
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor12 / 26384545
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia0 / 972500 
normal133 / 336030739
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood4 / 12347832
bone4 / 7165555
bone marrow1 / 4880120
brain29 / 110098926
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye3 / 21105414
heart3 / 8962633
intestine1 / 2344724
kidney9 / 21177742
larynx0 / 241450 
liver3 / 20774314
lung22 / 33697465
lymph3 / 4427067
lymph node6 / 9161065
mammary gland2 / 15327113
mouth0 / 670520 
muscle7 / 10771564
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta14 / 28082549
prostate5 / 18934526
salivary gland1 / 2015549
skin4 / 21057418
spleen1 / 5395218
stomach4 / 9661941
testis13 / 33044239
thymus5 / 8113161
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord1 / 1368073
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203598_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.55
Adipocyte10.2
AdrenalCortex13.85
Adrenalgland9.55
Amygdala10.4
Appendix15.7
AtrioventricularNode15.95
BDCA4+_DentriticCells10.6
Bonemarrow12.15
BronchialEpithelialCells9.9
CD105+_Endothelial12.05
CD14+_Monocytes12.1
CD19+_BCells(neg._sel.)11.4
CD33+_Myeloid13.2
CD34+14.5
CD4+_Tcells10.45
CD56+_NKCells11.9
CD71+_EarlyErythroid18.6
CD8+_Tcells9
CardiacMyocytes20.6
Caudatenucleus9.85
Cerebellum8.65
CerebellumPeduncles13.65
CiliaryGanglion15.65
CingulateCortex12.1
Colorectaladenocarcinoma19.05
DorsalRootGanglion12.85
FetalThyroid10.85
Fetalbrain10.5
Fetalliver9.6
Fetallung7.6
GlobusPallidus9.25
Heart18.55
Hypothalamus10.5
Kidney11.15
Leukemia_chronicMyelogenousK-5629.2
Leukemia_promyelocytic-HL-609.55
Leukemialymphoblastic(MOLT-4)8.05
Liver16.65
Lung11.25
Lymphnode8.65
Lymphoma_burkitts(Daudi)14.95
Lymphoma_burkitts(Raji)17.65
MedullaOblongata9.8
OccipitalLobe12.75
OlfactoryBulb9.85
Ovary10.2
Pancreas9.4
PancreaticIslet11.4
ParietalLobe13.6
Pituitary12.45
Placenta10.1
Pons11.15
PrefrontalCortex12.5
Prostate11.25
Salivarygland10.4
SkeletalMuscle16.85
Skin12.4
SmoothMuscle11.65
Spinalcord11.2
SubthalamicNucleus11.85
SuperiorCervicalGanglion24.85
TemporalLobe11.5
Testis8.85
TestisGermCell9.2
TestisIntersitial9.9
TestisLeydigCell12.2
TestisSeminiferousTubule9.6
Thalamus11.55
Thymus7.5
Thyroid12.2
Tongue14.4
Tonsil11.4
Trachea8.55
TrigeminalGanglion16.05
Uterus10.3
UterusCorpus12.2
WholeBlood11.75
Wholebrain7.65
colon10.3
pineal_day16.12
pineal_night19.92
retina12.85
small_intestine9.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P140035
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.56 ± 0.21
Basal Forebrain7.49 ± 0.24
Basal Part of Pons7.2 ± 0.24
Cerebellar Cortex7.29 ± 0.18
Cerebellar Nuclei7.61 ± 0.17
Claustrum7.73 ± 0.34
Epithalamus7.47 ± 0.36
Frontal Lobe7.45 ± 0.25
Globus Pallidus7.91 ± 0.23
Hypothalamus7.67 ± 0.27
Insula7.45 ± 0.28
Limbic Lobe7.46 ± 0.26
Mesencephalon7.55 ± 0.27
Myelencephalon7.45 ± 0.26
Occipital Lobe7.59 ± 0.24
Parietal Lobe7.51 ± 0.21
Pontine Tegmentum7.61 ± 0.3
Striatum7.67 ± 0.22
Subthalamus7.69 ± 0.13
Temporal Lobe7.4 ± 0.32
Thalamus7.51 ± 0.3
White Matter8.21 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wbp4CBCerebellum8.17
9.53
Wbp4CTXCerebral cortex6.89
5.13
Wbp4HIPHippocampal region12.17
11.92
Wbp4HPFHippocampal formation10.67
9.45
Wbp4HYHypothalamus6.11
4.89
Wbp4LSXLateral septal complex6.97
5.42
Wbp4MBMidbrain4.09
4.47
Wbp4MYMedulla5.53
7.28
Wbp4OLFOlfactory bulb21.79
16.78
Wbp4PPons6.91
9.13
Wbp4PALPallidum7.72
6.88
Wbp4RHPRetrohippocampal region7.33
5.26
Wbp4sAMYStriatum-like amygdalar nuclei7.65
5.07
Wbp4STRStriatum5.36
3.93
Wbp4STRdStriatum dorsal region2.19
1.6
Wbp4STRvStriatum ventral region12.52
8.67
Wbp4THThalamus7.33
6.21
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001480 15 18 32 CWIADNRPSVEFHER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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