AutismKB 2.0

Annotation Detail for ADCY6


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Basic Information Top
Gene Symbol:ADCY6 ( AC6,DKFZp779F075,KIAA0422 )
Gene Full Name: adenylate cyclase 6
Band: 12q13.12
Quick LinksEntrez ID:112; OMIM: 600294; Uniprot ID:ADCY6_HUMAN; ENSEMBL ID: ENSG00000174233; HGNC ID: 237
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst5 / 6231980
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult92 / 193912147
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult0 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor3 / 3436687
chondrosarcoma11 / 82823132
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor5 / 26384518
glioma9 / 10688384
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal137 / 336030740
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor6 / 9025766
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal2 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites2 / 4001549
bladder1 / 2975733
blood1 / 1234788
bone10 / 71655139
bone marrow0 / 488010 
brain38 / 110098934
cervix4 / 4817183
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye9 / 21105442
heart5 / 8962655
intestine18 / 23447276
kidney8 / 21177737
larynx3 / 24145124
liver10 / 20774348
lung19 / 33697456
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary5 / 10205148
pancreas13 / 21481260
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate7 / 18934536
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach4 / 9661941
testis2 / 3304426
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209195_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.95
Adipocyte6.2
AdrenalCortex4.65
Adrenalgland3.8
Amygdala5.3
Appendix4.55
AtrioventricularNode3.4
BDCA4+_DentriticCells5.15
Bonemarrow4.5
BronchialEpithelialCells4.55
CD105+_Endothelial4.7
CD14+_Monocytes4.75
CD19+_BCells(neg._sel.)4.7
CD33+_Myeloid5.85
CD34+6.55
CD4+_Tcells4.75
CD56+_NKCells5.2
CD71+_EarlyErythroid4.25
CD8+_Tcells4.25
CardiacMyocytes5.7
Caudatenucleus4.05
Cerebellum3.75
CerebellumPeduncles5.15
CiliaryGanglion3.35
CingulateCortex5.4
Colorectaladenocarcinoma4.65
DorsalRootGanglion3.55
FetalThyroid4.5
Fetalbrain7.05
Fetalliver3.95
Fetallung4.3
GlobusPallidus3.35
Heart6.65
Hypothalamus5.95
Kidney3.7
Leukemia_chronicMyelogenousK-5624.15
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)3.5
Liver5.85
Lung5.15
Lymphnode4
Lymphoma_burkitts(Daudi)5.8
Lymphoma_burkitts(Raji)6.3
MedullaOblongata4.25
OccipitalLobe4.1
OlfactoryBulb5.15
Ovary3.8
Pancreas3.65
PancreaticIslet4.9
ParietalLobe4.75
Pituitary5.4
Placenta4.85
Pons4.35
PrefrontalCortex6.45
Prostate6.4
Salivarygland3.65
SkeletalMuscle5.05
Skin3.5
SmoothMuscle5.3
Spinalcord4.95
SubthalamicNucleus4.1
SuperiorCervicalGanglion5.45
TemporalLobe4.15
Testis3.95
TestisGermCell3.85
TestisIntersitial3.8
TestisLeydigCell4.5
TestisSeminiferousTubule3.85
Thalamus4.65
Thymus3.55
Thyroid5.85
Tongue4.4
Tonsil4.45
Trachea3.85
TrigeminalGanglion4.5
Uterus3.85
UterusCorpus4.1
WholeBlood5
Wholebrain4.05
colon4.65
pineal_day6.56
pineal_night6.74
retina6.8
small_intestine4.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P501547
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.9 ± 0.69
Basal Forebrain3.6 ± 0.41
Basal Part of Pons4.02 ± 0.96
Cerebellar Cortex4.42 ± 0.36
Cerebellar Nuclei3.96 ± 0.68
Claustrum3.56 ± 0.78
Epithalamus3.84 ± 0.83
Frontal Lobe4.07 ± 0.64
Globus Pallidus3.06 ± 0.49
Hypothalamus3.66 ± 0.71
Insula4.14 ± 0.57
Limbic Lobe3.82 ± 0.68
Mesencephalon4.05 ± 0.78
Myelencephalon3.87 ± 0.61
Occipital Lobe3.79 ± 0.76
Parietal Lobe3.94 ± 0.74
Pontine Tegmentum3.89 ± 0.71
Striatum2.72 ± 0.86
Subthalamus4.14 ± 1.11
Temporal Lobe4.15 ± 0.5
Thalamus3.85 ± 0.67
White Matter3.25 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adcy6CBCerebellum2.98
2.99
Adcy6CTXCerebral cortex10.21
5.94
Adcy6HIPHippocampal region21.91
12.68
Adcy6HPFHippocampal formation21.11
12.65
Adcy6HYHypothalamus12.83
6.92
Adcy6LSXLateral septal complex4.75
2.43
Adcy6MBMidbrain3.97
2.59
Adcy6MYMedulla5.71
3.73
Adcy6OLFOlfactory bulb16.98
9.08
Adcy6PPons4.99
3.14
Adcy6PALPallidum7.79
4.73
Adcy6RHPRetrohippocampal region20.36
12.42
Adcy6sAMYStriatum-like amygdalar nuclei35.99
20.21
Adcy6STRStriatum6.73
3.96
Adcy6STRdStriatum dorsal region3.64
2.35
Adcy6STRvStriatum ventral region4.42
2.43
Adcy6THThalamus8.36
4.38
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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