AutismKB 2.0

Annotation Detail for CHKB


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Basic Information Top
Gene Symbol:CHKB ( CHETK,CHKL,CK,CKB,CKEKB,EK,EKB )
Gene Full Name: choline kinase beta
Band: 22q13.33
Quick LinksEntrez ID:1120; OMIM: 612395; Uniprot ID:CHKB_HUMAN; ENSEMBL ID: ENSG00000100288; HGNC ID: 1938
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst3 / 6231948
fetus30 / 56401253
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult130 / 193912167
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal176 / 336030752
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer11 / 102680107
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood4 / 12347832
bone4 / 7165555
bone marrow8 / 48801163
brain52 / 110098947
cervix1 / 4817120
connective tissue7 / 14925546
ear2 / 16212123
embryonic tissue12 / 21572255
esophagus1 / 2020949
eye2 / 2110549
heart6 / 8962666
intestine11 / 23447246
kidney10 / 21177747
larynx1 / 2414541
liver7 / 20774333
lung20 / 33697459
lymph1 / 4427022
lymph node6 / 9161065
mammary gland1 / 1532716
mouth4 / 6705259
muscle0 / 1077150 
nerve1 / 1576863
ovary8 / 10205178
pancreas5 / 21481223
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta25 / 28082589
prostate17 / 18934589
salivary gland1 / 2015549
skin3 / 21057414
spleen5 / 5395292
stomach0 / 966190 
testis20 / 33044260
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204193_at
Cell line Expression level Expression bar
721_B_lymphoblasts83.8
Adipocyte55.75
AdrenalCortex66.9
Adrenalgland57.35
Amygdala67.55
Appendix56.25
AtrioventricularNode26.1
BDCA4+_DentriticCells208.3
Bonemarrow51.55
BronchialEpithelialCells40.9
CD105+_Endothelial66.3
CD14+_Monocytes476.15
CD19+_BCells(neg._sel.)181.5
CD33+_Myeloid382.7
CD34+270.55
CD4+_Tcells162.35
CD56+_NKCells308.8
CD71+_EarlyErythroid31
CD8+_Tcells145.15
CardiacMyocytes71.4
Caudatenucleus58.4
Cerebellum59
CerebellumPeduncles96.35
CiliaryGanglion26.45
CingulateCortex64.4
Colorectaladenocarcinoma41.85
DorsalRootGanglion37.75
FetalThyroid111.55
Fetalbrain60.55
Fetalliver40.35
Fetallung56.45
GlobusPallidus39.15
Heart136.25
Hypothalamus79.35
Kidney53.2
Leukemia_chronicMyelogenousK-56235.75
Leukemia_promyelocytic-HL-6045.75
Leukemialymphoblastic(MOLT-4)53.05
Liver63.75
Lung90.95
Lymphnode123.05
Lymphoma_burkitts(Daudi)76.5
Lymphoma_burkitts(Raji)74.45
MedullaOblongata47.3
OccipitalLobe60.45
OlfactoryBulb60.85
Ovary33.25
Pancreas38.1
PancreaticIslet55.65
ParietalLobe71.95
Pituitary115.7
Placenta49.4
Pons61.85
PrefrontalCortex68.2
Prostate76.65
Salivarygland44.5
SkeletalMuscle71.7
Skin46.9
SmoothMuscle70.1
Spinalcord64.6
SubthalamicNucleus50.65
SuperiorCervicalGanglion52.35
TemporalLobe56
Testis122.15
TestisGermCell64.55
TestisIntersitial62.95
TestisLeydigCell64.6
TestisSeminiferousTubule69.7
Thalamus65.8
Thymus61.3
Thyroid125.25
Tongue65.95
Tonsil75.7
Trachea54.45
TrigeminalGanglion30.6
Uterus54.1
UterusCorpus60.6
WholeBlood88
Wholebrain60.9
colon63.2
pineal_day113
pineal_night106.62
retina79.575
small_intestine62.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13002_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.34 ± 0.58
Basal Forebrain5.69 ± 0.33
Basal Part of Pons5.8 ± 0.55
Cerebellar Cortex6.04 ± 0.34
Cerebellar Nuclei5.43 ± 0.34
Claustrum5.17 ± 0.61
Epithalamus6.05 ± 0.52
Frontal Lobe5.61 ± 0.5
Globus Pallidus5.25 ± 0.47
Hypothalamus5.54 ± 0.64
Insula5.61 ± 0.32
Limbic Lobe5.6 ± 0.44
Mesencephalon5.61 ± 0.43
Myelencephalon5.61 ± 0.5
Occipital Lobe5.59 ± 0.41
Parietal Lobe5.61 ± 0.39
Pontine Tegmentum5.54 ± 0.42
Striatum5.3 ± 0.42
Subthalamus5.32 ± 0.22
Temporal Lobe5.73 ± 0.41
Thalamus5.57 ± 0.43
White Matter5.67 ± 0.49
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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