AutismKB 2.0

Annotation Detail for PROSC


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Basic Information Top
Gene Symbol:PROSC ( FLJ11861 )
Gene Full Name: proline synthetase co-transcribed homolog (bacterial)
Band: 8p11.2
Quick LinksEntrez ID:11212; OMIM: 604436; Uniprot ID:PROSC_HUMAN; ENSEMBL ID: ENSG00000147471; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus27 / 56401247
neonate4 / 31097128
infant1 / 2362042
juvenile5 / 5555689
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor12 / 26384545
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia5 / 9584252
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal184 / 336030754
ovarian tumor7 / 7668291
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer7 / 10268068
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites5 / 40015124
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow2 / 4880140
brain73 / 110098966
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye14 / 21105466
heart3 / 8962633
intestine29 / 234472123
kidney15 / 21177770
larynx0 / 241450 
liver4 / 20774319
lung26 / 33697477
lymph1 / 4427022
lymph node8 / 9161087
mammary gland4 / 15327126
mouth0 / 670520 
muscle4 / 10771537
nerve1 / 1576863
ovary7 / 10205168
pancreas15 / 21481269
parathyroid7 / 20539340
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta6 / 28082521
prostate11 / 18934558
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach6 / 9661962
testis14 / 33044242
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus17 / 23287872
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209384_at
Cell line Expression level Expression bar
721_B_lymphoblasts181.8
Adipocyte25.25
AdrenalCortex11.7
Adrenalgland24.25
Amygdala85.1
Appendix28.85
AtrioventricularNode14.1
BDCA4+_DentriticCells103.3
Bonemarrow19.6
BronchialEpithelialCells35.1
CD105+_Endothelial101.25
CD14+_Monocytes227.25
CD19+_BCells(neg._sel.)58.2
CD33+_Myeloid221.9
CD34+184.8
CD4+_Tcells34.15
CD56+_NKCells175.9
CD71+_EarlyErythroid58.75
CD8+_Tcells55.8
CardiacMyocytes8.35
Caudatenucleus34.3
Cerebellum23.4
CerebellumPeduncles28.8
CiliaryGanglion4.9
CingulateCortex22
Colorectaladenocarcinoma25.1
DorsalRootGanglion5.45
FetalThyroid28.3
Fetalbrain19.3
Fetalliver24.95
Fetallung21.25
GlobusPallidus17.6
Heart13.25
Hypothalamus37.8
Kidney66.25
Leukemia_chronicMyelogenousK-56240.75
Leukemia_promyelocytic-HL-6029.6
Leukemialymphoblastic(MOLT-4)60.9
Liver31.5
Lung34.15
Lymphnode25.45
Lymphoma_burkitts(Daudi)39.3
Lymphoma_burkitts(Raji)15.2
MedullaOblongata33.9
OccipitalLobe41
OlfactoryBulb24.75
Ovary12.5
Pancreas15.05
PancreaticIslet45.2
ParietalLobe21.9
Pituitary33.75
Placenta24.05
Pons22.85
PrefrontalCortex53.95
Prostate38.75
Salivarygland24.25
SkeletalMuscle16.6
Skin7.7
SmoothMuscle19.25
Spinalcord40.75
SubthalamicNucleus22.65
SuperiorCervicalGanglion15.9
TemporalLobe26.4
Testis13.6
TestisGermCell8.2
TestisIntersitial7.05
TestisLeydigCell14.45
TestisSeminiferousTubule8.8
Thalamus27.5
Thymus28.3
Thyroid72.3
Tongue18.85
Tonsil19.4
Trachea32.35
TrigeminalGanglion15.35
Uterus26.85
UterusCorpus21.05
WholeBlood82.45
Wholebrain55.5
colon46.25
pineal_day64.94
pineal_night39.16
retina50.475
small_intestine43.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P251186
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.51 ± 0.34
Basal Forebrain5.12 ± 0.36
Basal Part of Pons5.44 ± 0.34
Cerebellar Cortex5.28 ± 0.39
Cerebellar Nuclei5.04 ± 0.58
Claustrum5.28 ± 0.62
Epithalamus5.31 ± 0.18
Frontal Lobe5.33 ± 0.35
Globus Pallidus5.12 ± 0.56
Hypothalamus5.16 ± 0.48
Insula5.36 ± 0.36
Limbic Lobe5.42 ± 0.43
Mesencephalon5.25 ± 0.49
Myelencephalon5.28 ± 0.47
Occipital Lobe5.11 ± 0.55
Parietal Lobe5.32 ± 0.38
Pontine Tegmentum5.25 ± 0.47
Striatum5.3 ± 0.38
Subthalamus5.13 ± 0.34
Temporal Lobe5.34 ± 0.43
Thalamus5.11 ± 0.44
White Matter5.5 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ProscCBCerebellum19.31
19.65
ProscCTXCerebral cortex53.63
19.85
ProscHIPHippocampal region24.74
19.54
ProscHPFHippocampal formation34.26
18.46
ProscHYHypothalamus11.69
4.11
ProscLSXLateral septal complex14.85
5.71
ProscMBMidbrain16.44
8.2
ProscMYMedulla33.22
25.02
ProscOLFOlfactory bulb34.29
11.5
ProscPPons28.07
17.17
ProscPALPallidum14.41
5.69
ProscRHPRetrohippocampal region47.43
17.57
ProscsAMYStriatum-like amygdalar nuclei24.45
7.44
ProscSTRStriatum9.07
2.87
ProscSTRdStriatum dorsal region5.46
1.69
ProscSTRvStriatum ventral region10.33
3
ProscTHThalamus9.81
3.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000831 15 261 275 CAADVKAPLEVAQEH Peptide Atlas
PROSC_HUMAN_0 0 0 0 DLPAIQPR PRIDE
PROSC_HUMAN_0 0 0 0 ILSLCPEIK PRIDE
PROSC_HUMAN_0 0 0 0 LMAVPNLFMLETVDSVK PRIDE
PROSC_HUMAN_0 0 0 0 TFGENYVQELLEK PRIDE
PROSC_HUMAN_0 0 0 0 VMVQINTSGEESK PRIDE
PROSC_HUMAN_104 17 104 120 LMAVPNLFMLETVDSVK PRIDE
PROSC_HUMAN_140 13 140 152 VMVQINTSGEESK PRIDE
PROSC_HUMAN_33 8 33 40 DLPAIQPR PRIDE
PROSC_HUMAN_47 16 47 62 TKPADMVIEAYGHGQR PRIDE
PROSC_HUMAN_48 16 48 63 TKPADMVIEAYGHGQR PRIDE
PROSC_HUMAN_63 13 63 75 TFGENYVQELLEK PRIDE
PROSC_HUMAN_8 11 8 18 SAELGVGCALR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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