AutismKB 2.0

Annotation Detail for AKAP13


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Basic Information Top
Gene Symbol:AKAP13 ( AKAP-Lbc,ARHGEF13,BRX,FLJ11952,FLJ43341,HA-3,Ht31,LBC,PROTO-LB,PROTO-LBC,c-lbc )
Gene Full Name: A kinase (PRKA) anchor protein 13
Band: 15q25.3
Quick LinksEntrez ID:11214; OMIM: 604686; Uniprot ID:AKP13_HUMAN; ENSEMBL ID: ENSG00000170776; HGNC ID: 371
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus68 / 564012120
neonate0 / 310970 
infant0 / 236200 
juvenile3 / 5555653
adult329 / 1939121169
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult18 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor11 / 94178116
cervical tumor1 / 3436629
chondrosarcoma12 / 82823144
colorectal tumor13 / 114246113
esophageal tumor2 / 17290115
gastrointestinal tumor15 / 119369125
germ cell tumor14 / 26384553
glioma15 / 106883140
head and neck tumor14 / 136302102
kidney tumor7 / 68959101
leukemia20 / 95842208
liver tumor4 / 9635941
lung tumor7 / 10312767
lymphoma15 / 71755209
non-neoplasia9 / 9725092
normal416 / 3360307123
ovarian tumor6 / 7668278
pancreatic tumor11 / 104616105
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer7 / 10268068
retinoblastoma16 / 46356345
skin tumor9 / 12494972
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor11 / 90257121
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal23 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites6 / 40015149
bladder6 / 29757201
blood18 / 123478145
bone9 / 71655125
bone marrow1 / 4880120
brain66 / 110098959
cervix2 / 4817141
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus2 / 2020998
eye29 / 211054137
heart13 / 89626145
intestine26 / 234472110
kidney15 / 21177770
larynx2 / 2414582
liver11 / 20774352
lung44 / 336974130
lymph15 / 44270338
lymph node35 / 91610382
mammary gland92 / 153271600
mouth10 / 67052149
muscle11 / 107715102
nerve5 / 15768317
ovary6 / 10205158
pancreas24 / 214812111
parathyroid0 / 205390 
pharynx8 / 41328193
pituitary gland3 / 16585180
placenta44 / 280825156
prostate10 / 18934552
salivary gland0 / 201550 
skin18 / 21057485
spleen14 / 53952259
stomach12 / 96619124
testis18 / 33044254
thymus6 / 8113173
thyroid2 / 4747342
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord1 / 1368073
uterus39 / 232878167
vascular3 / 5178057
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain10 / 11009899
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney7 / 21177733
larynx0 / 241450 
liver2 / 2077439
lung1 / 3369742
lymph0 / 442700 
lymph node1 / 9161010
mammary gland1 / 1532716
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209534_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts95.3
Adipocyte114.9
AdrenalCortex131.45
Adrenalgland67
Amygdala75.7
Appendix67.95
AtrioventricularNode59.85
BDCA4+_DentriticCells253
Bonemarrow103
BronchialEpithelialCells71.9
CD105+_Endothelial64.85
CD14+_Monocytes143.8
CD19+_BCells(neg._sel.)128.15
CD33+_Myeloid454.55
CD34+93.4
CD4+_Tcells254.6
CD56+_NKCells493
CD71+_EarlyErythroid25.9
CD8+_Tcells171.5
CardiacMyocytes93.65
Caudatenucleus72
Cerebellum65.1
CerebellumPeduncles103.6
CiliaryGanglion76.55
CingulateCortex82.1
Colorectaladenocarcinoma65.15
DorsalRootGanglion56.45
FetalThyroid149.35
Fetalbrain77.45
Fetalliver68.65
Fetallung87.4
GlobusPallidus53.6
Heart101.85
Hypothalamus68.8
Kidney78.05
Leukemia_chronicMyelogenousK-56257
Leukemia_promyelocytic-HL-6056.15
Leukemialymphoblastic(MOLT-4)49.5
Liver167
Lung419
Lymphnode79.85
Lymphoma_burkitts(Daudi)74.55
Lymphoma_burkitts(Raji)91.7
MedullaOblongata73.6
OccipitalLobe67.95
OlfactoryBulb72.85
Ovary53.85
Pancreas95.9
PancreaticIslet67.25
ParietalLobe78.85
Pituitary143.25
Placenta95.55
Pons61.7
PrefrontalCortex106.95
Prostate184.1
Salivarygland53.85
SkeletalMuscle81.8
Skin57.95
SmoothMuscle73.7
Spinalcord77.8
SubthalamicNucleus55.5
SuperiorCervicalGanglion71.75
TemporalLobe77.8
Testis81.75
TestisGermCell90.9
TestisIntersitial85.4
TestisLeydigCell75.4
TestisSeminiferousTubule130.4
Thalamus74.35
Thymus119.65
Thyroid108.1
Tongue83.35
Tonsil149.65
Trachea75.4
TrigeminalGanglion62.25
Uterus489.45
UterusCorpus76.55
WholeBlood109.75
Wholebrain54.35
colon73.7
pineal_day95.06
pineal_night84.72
retina92.025
small_intestine70.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P155761
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.13 ± 0.25
Basal Forebrain8.08 ± 0.21
Basal Part of Pons8.3 ± 0.33
Cerebellar Cortex7.51 ± 0.36
Cerebellar Nuclei7.89 ± 0.26
Claustrum8.95 ± 0.49
Epithalamus8.81 ± 0.45
Frontal Lobe7.79 ± 0.37
Globus Pallidus8.4 ± 0.31
Hypothalamus8.11 ± 0.38
Insula7.93 ± 0.4
Limbic Lobe8.26 ± 0.51
Mesencephalon8.15 ± 0.6
Myelencephalon8.11 ± 0.49
Occipital Lobe8.38 ± 0.34
Parietal Lobe8.14 ± 0.55
Pontine Tegmentum7.93 ± 0.31
Striatum8.44 ± 0.38
Subthalamus8.53 ± 0.32
Temporal Lobe8.23 ± 0.3
Thalamus7.93 ± 0.4
White Matter7.73 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Akap13CBCerebellum0.71
1.36
Akap13CTXCerebral cortex1.83
1.95
Akap13HIPHippocampal region10.77
10.16
Akap13HPFHippocampal formation8.35
7.16
Akap13HYHypothalamus0.34
0.39
Akap13LSXLateral septal complex0.7
0.47
Akap13MBMidbrain0.49
0.85
Akap13MYMedulla0.81
0.98
Akap13OLFOlfactory bulb10.59
8.41
Akap13PPons0.6
0.88
Akap13PALPallidum0.3
0.45
Akap13RHPRetrohippocampal region5.26
3.83
Akap13sAMYStriatum-like amygdalar nuclei0.41
0.62
Akap13STRStriatum0.36
0.51
Akap13STRdStriatum dorsal region0.38
0.56
Akap13STRvStriatum ventral region0.19
0.34
Akap13THThalamus1.07
1.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AKP13_HUMAN_2067 9 2067 2075 SEKNFLIKR PRIDE
PAp00041028 34 531 564 ISVPNCAPAASSLDGNKPAESSLAFSNEETSTEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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