AutismKB 2.0

Annotation Detail for DUSP10


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Basic Information Top
Gene Symbol:DUSP10 ( MKP-5,MKP5 )
Gene Full Name: dual specificity phosphatase 10
Band: 1q41
Quick LinksEntrez ID:11221; OMIM: 608867; Uniprot ID:DUS10_HUMAN; ENSEMBL ID: ENSG00000143507; HGNC ID: 3065
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus16 / 56401228
neonate3 / 3109796
infant0 / 236200 
juvenile0 / 555560 
adult60 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia7 / 9725071
normal100 / 336030729
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor10 / 12494980
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder2 / 2975767
blood6 / 12347848
bone5 / 7165569
bone marrow4 / 4880181
brain36 / 110098932
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye4 / 21105418
heart3 / 8962633
intestine14 / 23447259
kidney7 / 21177733
larynx0 / 241450 
liver5 / 20774324
lung8 / 33697423
lymph1 / 4427022
lymph node1 / 9161010
mammary gland5 / 15327132
mouth7 / 67052104
muscle5 / 10771546
nerve1 / 1576863
ovary2 / 10205119
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin17 / 21057480
spleen1 / 5395218
stomach2 / 9661920
testis3 / 3304429
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221563_at
Cell line Expression level Expression bar
721_B_lymphoblasts60.9
Adipocyte9
AdrenalCortex7.85
Adrenalgland5.7
Amygdala6.6
Appendix7.35
AtrioventricularNode6.1
BDCA4+_DentriticCells7.35
Bonemarrow7.05
BronchialEpithelialCells8.35
CD105+_Endothelial6.3
CD14+_Monocytes19.05
CD19+_BCells(neg._sel.)10.05
CD33+_Myeloid16.25
CD34+22
CD4+_Tcells6.55
CD56+_NKCells11.9
CD71+_EarlyErythroid6.2
CD8+_Tcells6.5
CardiacMyocytes10.45
Caudatenucleus5.9
Cerebellum12.1
CerebellumPeduncles7.65
CiliaryGanglion5.4
CingulateCortex6.85
Colorectaladenocarcinoma6.35
DorsalRootGanglion5.75
FetalThyroid6.5
Fetalbrain6.15
Fetalliver5.8
Fetallung5.2
GlobusPallidus5.05
Heart10
Hypothalamus7.1
Kidney5.75
Leukemia_chronicMyelogenousK-5625.95
Leukemia_promyelocytic-HL-605.8
Leukemialymphoblastic(MOLT-4)5
Liver9.8
Lung6.95
Lymphnode5.45
Lymphoma_burkitts(Daudi)8.55
Lymphoma_burkitts(Raji)9.65
MedullaOblongata5.95
OccipitalLobe5.95
OlfactoryBulb5
Ovary5.05
Pancreas5.3
PancreaticIslet7.15
ParietalLobe7.2
Pituitary7.4
Placenta6.35
Pons6.35
PrefrontalCortex8.9
Prostate7.45
Salivarygland5.6
SkeletalMuscle9.15
Skin5.95
SmoothMuscle7.4
Spinalcord6.95
SubthalamicNucleus6.5
SuperiorCervicalGanglion9.35
TemporalLobe6.15
Testis5.75
TestisGermCell5.05
TestisIntersitial5.65
TestisLeydigCell6.6
TestisSeminiferousTubule5.5
Thalamus6.8
Thymus4.8
Thyroid7.8
Tongue6.95
Tonsil9.75
Trachea5.4
TrigeminalGanglion10.6
Uterus5.2
UterusCorpus6.3
WholeBlood10.75
Wholebrain5.4
colon6.4
pineal_day8.32
pineal_night8.28
retina8.075
small_intestine6.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P182494
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.95 ± 0.92
Basal Forebrain4.18 ± 0.5
Basal Part of Pons3.65 ± 0.6
Cerebellar Cortex4.44 ± 0.36
Cerebellar Nuclei4.38 ± 0.31
Claustrum3.7 ± 0.72
Epithalamus4.22 ± 0.79
Frontal Lobe3.87 ± 0.69
Globus Pallidus4.31 ± 0.62
Hypothalamus3.79 ± 0.78
Insula3.92 ± 0.42
Limbic Lobe3.76 ± 0.75
Mesencephalon4.03 ± 0.71
Myelencephalon3.97 ± 0.69
Occipital Lobe3.98 ± 0.63
Parietal Lobe4.01 ± 0.64
Pontine Tegmentum4.09 ± 0.71
Striatum3.89 ± 0.81
Subthalamus3.65 ± 0.28
Temporal Lobe3.79 ± 0.56
Thalamus4.08 ± 0.5
White Matter5.72 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dusp10CBCerebellum64.88
90.87
Dusp10CTXCerebral cortex17.96
13.47
Dusp10HIPHippocampal region10.21
11.31
Dusp10HPFHippocampal formation12.51
11.67
Dusp10HYHypothalamus5.47
4.17
Dusp10LSXLateral septal complex3.39
2.56
Dusp10MBMidbrain9.55
9.56
Dusp10MYMedulla11.44
12.88
Dusp10OLFOlfactory bulb12.99
10.61
Dusp10PPons8
8.39
Dusp10PALPallidum14.26
12.9
Dusp10RHPRetrohippocampal region15.24
11.65
Dusp10sAMYStriatum-like amygdalar nuclei9.83
7.27
Dusp10STRStriatum6.22
4.52
Dusp10STRdStriatum dorsal region8.66
5.06
Dusp10STRvStriatum ventral region4.87
3.16
Dusp10THThalamus8.71
8.09
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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