AutismKB 2.0

Annotation Detail for MRPL3


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Basic Information Top
Gene Symbol:MRPL3 ( MRL3,RPML3 )
Gene Full Name: mitochondrial ribosomal protein L3
Band: 3q22.1
Quick LinksEntrez ID:11222; OMIM: 607118; Uniprot ID:RM03_HUMAN; ENSEMBL ID: ENSG00000114686; HGNC ID: 10379
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst6 / 6231996
fetus69 / 564012122
neonate2 / 3109764
infant14 / 23620592
juvenile10 / 55556179
adult171 / 193912188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma4 / 17475228
breast (mammary gland) tumor7 / 9417874
cervical tumor6 / 34366174
chondrosarcoma13 / 82823156
colorectal tumor11 / 11424696
esophageal tumor2 / 17290115
gastrointestinal tumor26 / 119369217
germ cell tumor37 / 263845140
glioma16 / 106883149
head and neck tumor2 / 13630214
kidney tumor9 / 68959130
leukemia7 / 9584273
liver tumor16 / 96359166
lung tumor10 / 10312796
lymphoma12 / 71755167
non-neoplasia9 / 9725092
normal343 / 3360307102
ovarian tumor7 / 7668291
pancreatic tumor10 / 10461695
primitive neuroectodermal tumor of the CNS31 / 125680246
prostate cancer10 / 10268097
retinoblastoma9 / 46356194
skin tumor21 / 124949168
soft tissue/muscle tissue tumor31 / 125191247
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland10 / 33197301
ascites8 / 40015199
bladder3 / 29757100
blood10 / 12347880
bone13 / 71655181
bone marrow4 / 4880181
brain129 / 1100989117
cervix10 / 48171207
connective tissue24 / 149255160
ear3 / 16212185
embryonic tissue33 / 215722152
esophagus4 / 20209197
eye19 / 21105490
heart18 / 89626200
intestine24 / 234472102
kidney26 / 211777122
larynx1 / 2414541
liver26 / 207743125
lung34 / 336974100
lymph6 / 44270135
lymph node14 / 91610152
mammary gland15 / 15327197
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary13 / 102051127
pancreas21 / 21481297
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta33 / 280825117
prostate13 / 18934568
salivary gland2 / 2015599
skin24 / 210574113
spleen4 / 5395274
stomach26 / 96619269
testis48 / 330442145
thymus3 / 8113136
thyroid1 / 4747321
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord1 / 1368073
uterus38 / 232878163
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208787_at
Cell line Expression level Expression bar
721_B_lymphoblasts1710.2
Adipocyte190.75
AdrenalCortex39.7
Adrenalgland78.75
Amygdala265
Appendix16.25
AtrioventricularNode11.55
BDCA4+_DentriticCells398.7
Bonemarrow44.45
BronchialEpithelialCells836.05
CD105+_Endothelial906.9
CD14+_Monocytes315.45
CD19+_BCells(neg._sel.)283.8
CD33+_Myeloid260.8
CD34+842.3
CD4+_Tcells204.45
CD56+_NKCells270.4
CD71+_EarlyErythroid71.75
CD8+_Tcells263.95
CardiacMyocytes155.8
Caudatenucleus120.45
Cerebellum15.5
CerebellumPeduncles45.75
CiliaryGanglion16.55
CingulateCortex63.6
Colorectaladenocarcinoma599
DorsalRootGanglion39.35
FetalThyroid111.05
Fetalbrain164.15
Fetalliver119.65
Fetallung157.9
GlobusPallidus32.8
Heart19.55
Hypothalamus225.6
Kidney51.35
Leukemia_chronicMyelogenousK-562341.35
Leukemia_promyelocytic-HL-60788.55
Leukemialymphoblastic(MOLT-4)361.05
Liver15.9
Lung30.4
Lymphnode103.15
Lymphoma_burkitts(Daudi)867.85
Lymphoma_burkitts(Raji)681.25
MedullaOblongata76.9
OccipitalLobe112.55
OlfactoryBulb72.05
Ovary44.15
Pancreas142.75
PancreaticIslet275.75
ParietalLobe42.85
Pituitary246.8
Placenta58.3
Pons24.35
PrefrontalCortex123.4
Prostate219.95
Salivarygland112.7
SkeletalMuscle20.65
Skin16.2
SmoothMuscle376.95
Spinalcord94.95
SubthalamicNucleus76.65
SuperiorCervicalGanglion20.5
TemporalLobe63.65
Testis101.95
TestisGermCell237.2
TestisIntersitial201
TestisLeydigCell160.55
TestisSeminiferousTubule141.45
Thalamus118.55
Thymus53.75
Thyroid500.45
Tongue53.2
Tonsil136.85
Trachea102
TrigeminalGanglion14.5
Uterus178.45
UterusCorpus15.95
WholeBlood137.6
Wholebrain155.1
colon576.65
pineal_day301.54
pineal_night287.58
retina103.325
small_intestine470.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P7030
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.81 ± 0.25
Basal Forebrain8.7 ± 0.12
Basal Part of Pons8.67 ± 0.13
Cerebellar Cortex8.67 ± 0.26
Cerebellar Nuclei8.52 ± 0.26
Claustrum8.76 ± 0.28
Epithalamus8.79 ± 0.22
Frontal Lobe8.82 ± 0.29
Globus Pallidus8.47 ± 0.3
Hypothalamus8.94 ± 0.22
Insula8.94 ± 0.18
Limbic Lobe8.91 ± 0.32
Mesencephalon8.76 ± 0.31
Myelencephalon8.76 ± 0.28
Occipital Lobe8.76 ± 0.27
Parietal Lobe8.82 ± 0.27
Pontine Tegmentum8.83 ± 0.29
Striatum8.65 ± 0.32
Subthalamus8.56 ± 0.31
Temporal Lobe8.87 ± 0.27
Thalamus8.75 ± 0.26
White Matter8.69 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mrpl3CBCerebellum24.63
50.02
Mrpl3CTXCerebral cortex53.44
46.31
Mrpl3HIPHippocampal region36.83
63.83
Mrpl3HPFHippocampal formation41.85
54.84
Mrpl3HYHypothalamus10.71
9.39
Mrpl3LSXLateral septal complex10.37
7.8
Mrpl3MBMidbrain22.67
24.35
Mrpl3MYMedulla34.37
42.99
Mrpl3OLFOlfactory bulb49.15
46.23
Mrpl3PPons23.88
28.98
Mrpl3PALPallidum18.2
17.55
Mrpl3RHPRetrohippocampal region50.81
45.04
Mrpl3sAMYStriatum-like amygdalar nuclei12.83
8.92
Mrpl3STRStriatum25.4
20.64
Mrpl3STRdStriatum dorsal region21.8
18.72
Mrpl3STRvStriatum ventral region51.55
37.67
Mrpl3THThalamus29.16
28.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003619 15 117 131 HVVTLLQVQDCHVLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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