AutismKB 2.0

Annotation Detail for SEC63


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Basic Information Top
Gene Symbol:SEC63 ( ERdj2,PRO2507,SEC63L )
Gene Full Name: SEC63 homolog (S. cerevisiae)
Band: 6q21
Quick LinksEntrez ID:11231; OMIM: 608648; Uniprot ID:SEC63_HUMAN; ENSEMBL ID: ENSG00000025796; HGNC ID: 21082
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst5 / 6231980
fetus52 / 56401292
neonate2 / 3109764
infant0 / 236200 
juvenile9 / 55556161
adult193 / 193912199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor15 / 94178159
cervical tumor5 / 34366145
chondrosarcoma5 / 8282360
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor19 / 26384572
glioma0 / 1068830 
head and neck tumor30 / 136302220
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor11 / 96359114
lung tumor25 / 103127242
lymphoma1 / 7175513
non-neoplasia14 / 97250143
normal204 / 336030760
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer24 / 102680233
retinoblastoma6 / 46356129
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland1 / 3319730
ascites2 / 4001549
bladder0 / 297570 
blood6 / 12347848
bone6 / 7165583
bone marrow8 / 48801163
brain55 / 110098949
cervix5 / 48171103
connective tissue10 / 14925566
ear8 / 16212493
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye14 / 21105466
heart8 / 8962689
intestine12 / 23447251
kidney15 / 21177770
larynx22 / 24145911
liver19 / 20774391
lung37 / 336974109
lymph0 / 442700 
lymph node4 / 9161043
mammary gland21 / 153271137
mouth5 / 6705274
muscle7 / 10771564
nerve2 / 15768126
ovary4 / 10205139
pancreas12 / 21481255
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta17 / 28082560
prostate29 / 189345153
salivary gland0 / 201550 
skin11 / 21057452
spleen2 / 5395237
stomach4 / 9661941
testis34 / 330442102
thymus3 / 8113136
thyroid6 / 47473126
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord2 / 13680146
uterus18 / 23287877
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201916_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts225.8
Adipocyte109.15
AdrenalCortex48.4
Adrenalgland38.4
Amygdala186.15
Appendix40.95
AtrioventricularNode13.15
BDCA4+_DentriticCells368.4
Bonemarrow10.15
BronchialEpithelialCells148.65
CD105+_Endothelial58.45
CD14+_Monocytes89.7
CD19+_BCells(neg._sel.)203.35
CD33+_Myeloid209.35
CD34+299.6
CD4+_Tcells76.9
CD56+_NKCells211.9
CD71+_EarlyErythroid11.7
CD8+_Tcells116
CardiacMyocytes58.9
Caudatenucleus44.3
Cerebellum10.15
CerebellumPeduncles25.9
CiliaryGanglion9.9
CingulateCortex32.9
Colorectaladenocarcinoma29.95
DorsalRootGanglion22.25
FetalThyroid73.3
Fetalbrain48.5
Fetalliver64.15
Fetallung75
GlobusPallidus22.8
Heart13.55
Hypothalamus110
Kidney10.7
Leukemia_chronicMyelogenousK-562118.75
Leukemia_promyelocytic-HL-6093.45
Leukemialymphoblastic(MOLT-4)36.25
Liver11.3
Lung8.6
Lymphnode60.4
Lymphoma_burkitts(Daudi)148.8
Lymphoma_burkitts(Raji)129.85
MedullaOblongata31.8
OccipitalLobe50.8
OlfactoryBulb80.25
Ovary90.85
Pancreas117.6
PancreaticIslet263.05
ParietalLobe34.85
Pituitary225.05
Placenta24.75
Pons27.8
PrefrontalCortex66.35
Prostate46.7
Salivarygland402.4
SkeletalMuscle18.55
Skin19.3
SmoothMuscle147.75
Spinalcord113.45
SubthalamicNucleus30.2
SuperiorCervicalGanglion37.2
TemporalLobe38.85
Testis25.35
TestisGermCell155.45
TestisIntersitial66.3
TestisLeydigCell102.8
TestisSeminiferousTubule48.8
Thalamus49.05
Thymus19.8
Thyroid306.5
Tongue12.55
Tonsil22.1
Trachea180.7
TrigeminalGanglion15.45
Uterus126.05
UterusCorpus22.55
WholeBlood47.35
Wholebrain18.4
colon114.2
pineal_day130.5
pineal_night120.86
retina133.75
small_intestine68.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P123720
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.92 ± 0.34
Basal Forebrain5.89 ± 0.17
Basal Part of Pons5.77 ± 0.22
Cerebellar Cortex6.02 ± 0.26
Cerebellar Nuclei5.98 ± 0.39
Claustrum6.16 ± 0.32
Epithalamus5.65 ± 0.29
Frontal Lobe5.92 ± 0.29
Globus Pallidus5.39 ± 0.33
Hypothalamus6.03 ± 0.36
Insula6.02 ± 0.3
Limbic Lobe5.96 ± 0.4
Mesencephalon6.01 ± 0.38
Myelencephalon5.82 ± 0.35
Occipital Lobe5.82 ± 0.36
Parietal Lobe5.96 ± 0.3
Pontine Tegmentum5.92 ± 0.36
Striatum5.56 ± 0.31
Subthalamus6.1 ± 0.33
Temporal Lobe5.96 ± 0.3
Thalamus5.79 ± 0.26
White Matter5.54 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sec63CBCerebellum36.34
69.54
Sec63CTXCerebral cortex100
100
Sec63HIPHippocampal region100
100
Sec63HPFHippocampal formation100
100
Sec63HYHypothalamus77.32
80.61
Sec63LSXLateral septal complex57.03
52.48
Sec63MBMidbrain24.92
32.14
Sec63MYMedulla37.16
58.41
Sec63OLFOlfactory bulb100
100
Sec63PPons37.56
57.81
Sec63PALPallidum65.14
78.34
Sec63RHPRetrohippocampal region100
100
Sec63sAMYStriatum-like amygdalar nuclei100
100
Sec63STRStriatum91.79
87.65
Sec63STRdStriatum dorsal region91.41
83.84
Sec63STRvStriatum ventral region99.98
100
Sec63THThalamus62.26
71.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002191 21 486 506 EQSICAAEEQPAEDGQGETNK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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