AutismKB 2.0

Annotation Detail for MAN1B1


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Basic Information Top
Gene Symbol:MAN1B1 ( ERMan1,MANA-ER )
Gene Full Name: mannosidase, alpha, class 1B, member 1
Band: 9q34.3
Quick LinksEntrez ID:11253; OMIM: 604346; Uniprot ID:MA1B1_HUMAN; ENSEMBL ID: ENSG00000177239; HGNC ID: 6823
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus23 / 56401240
neonate6 / 31097192
infant2 / 2362084
juvenile5 / 5555689
adult127 / 193912165
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor6 / 34366174
chondrosarcoma23 / 82823277
colorectal tumor6 / 11424652
esophageal tumor2 / 17290115
gastrointestinal tumor9 / 11936975
germ cell tumor25 / 26384594
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor9 / 68959130
leukemia8 / 9584283
liver tumor6 / 9635962
lung tumor8 / 10312777
lymphoma5 / 7175569
non-neoplasia4 / 9725041
normal165 / 336030749
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS24 / 125680190
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor11 / 12494988
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites6 / 40015149
bladder0 / 297570 
blood9 / 12347872
bone8 / 71655111
bone marrow4 / 4880181
brain60 / 110098954
cervix13 / 48171269
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye10 / 21105447
heart8 / 8962689
intestine12 / 23447251
kidney16 / 21177775
larynx1 / 2414541
liver6 / 20774328
lung31 / 33697491
lymph0 / 442700 
lymph node2 / 9161021
mammary gland16 / 153271104
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate7 / 18934536
salivary gland0 / 201550 
skin26 / 210574123
spleen9 / 53952166
stomach3 / 9661931
testis19 / 33044257
thymus4 / 8113149
thyroid5 / 47473105
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus8 / 23287834
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218636_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts48.7
Adipocyte26.55
AdrenalCortex21.55
Adrenalgland18.5
Amygdala35.2
Appendix27.4
AtrioventricularNode20.35
BDCA4+_DentriticCells83.55
Bonemarrow26.55
BronchialEpithelialCells34.9
CD105+_Endothelial28
CD14+_Monocytes49.95
CD19+_BCells(neg._sel.)51.75
CD33+_Myeloid74.25
CD34+55.15
CD4+_Tcells82.25
CD56+_NKCells110.5
CD71+_EarlyErythroid22.55
CD8+_Tcells80.75
CardiacMyocytes74.4
Caudatenucleus20.55
Cerebellum13.65
CerebellumPeduncles26.75
CiliaryGanglion18.9
CingulateCortex24.2
Colorectaladenocarcinoma59.7
DorsalRootGanglion21.55
FetalThyroid28.9
Fetalbrain27.5
Fetalliver23.6
Fetallung27.15
GlobusPallidus19.05
Heart34.55
Hypothalamus32.7
Kidney12.6
Leukemia_chronicMyelogenousK-56223.35
Leukemia_promyelocytic-HL-6022.85
Leukemialymphoblastic(MOLT-4)23.2
Liver38.65
Lung47.15
Lymphnode26.2
Lymphoma_burkitts(Daudi)35.05
Lymphoma_burkitts(Raji)61.2
MedullaOblongata17.85
OccipitalLobe22.7
OlfactoryBulb26.75
Ovary18.15
Pancreas24.05
PancreaticIslet36.65
ParietalLobe24.15
Pituitary26.45
Placenta45.25
Pons18.55
PrefrontalCortex48.3
Prostate48.05
Salivarygland16.9
SkeletalMuscle7.95
Skin16.9
SmoothMuscle65.35
Spinalcord18.1
SubthalamicNucleus23.85
SuperiorCervicalGanglion28.55
TemporalLobe21.95
Testis30.5
TestisGermCell27.8
TestisIntersitial23.2
TestisLeydigCell25.15
TestisSeminiferousTubule29.6
Thalamus22.95
Thymus24.45
Thyroid84.95
Tongue21.8
Tonsil21.15
Trachea18.45
TrigeminalGanglion19.7
Uterus26.9
UterusCorpus19.7
WholeBlood23.15
Wholebrain30.9
colon27.9
pineal_day41.56
pineal_night48.14
retina35.325
small_intestine26.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P157943
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.57 ± 0.72
Basal Forebrain7.21 ± 0.14
Basal Part of Pons7.01 ± 0.29
Cerebellar Cortex7.01 ± 0.43
Cerebellar Nuclei7.42 ± 0.54
Claustrum7.72 ± 0.62
Epithalamus6.68 ± 0.17
Frontal Lobe7.04 ± 0.46
Globus Pallidus7.81 ± 0.4
Hypothalamus7 ± 0.59
Insula7.05 ± 0.42
Limbic Lobe7.31 ± 0.54
Mesencephalon7.24 ± 0.59
Myelencephalon7.2 ± 0.54
Occipital Lobe7.31 ± 0.51
Parietal Lobe7.14 ± 0.59
Pontine Tegmentum7.12 ± 0.53
Striatum7.34 ± 0.69
Subthalamus7.19 ± 0.23
Temporal Lobe7.12 ± 0.56
Thalamus7.09 ± 0.54
White Matter7.76 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Man1b1CBCerebellum24.03
33.7
Man1b1CTXCerebral cortex67.67
52.17
Man1b1HIPHippocampal region38.79
44.19
Man1b1HPFHippocampal formation46.19
46.51
Man1b1HYHypothalamus45.98
36.3
Man1b1LSXLateral septal complex29.55
20.54
Man1b1MBMidbrain42.27
38.02
Man1b1MYMedulla46.86
50.51
Man1b1OLFOlfactory bulb63
52.02
Man1b1PPons44.78
44.97
Man1b1PALPallidum43.02
40.83
Man1b1RHPRetrohippocampal region61.02
51.66
Man1b1sAMYStriatum-like amygdalar nuclei49.3
36.83
Man1b1STRStriatum31.62
23.19
Man1b1STRdStriatum dorsal region27.23
20.33
Man1b1STRvStriatum ventral region36.63
24.96
Man1b1THThalamus47.29
37.11
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040966 19 335 353 ILGGLLSAYHLSGDSLFLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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