AutismKB 2.0

Annotation Detail for USP18


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Basic Information Top
Gene Symbol:USP18 ( ISG43,UBP43 )
Gene Full Name: ubiquitin specific peptidase 18
Band: 22q11.2
Quick LinksEntrez ID:11274; OMIM: 607057; Uniprot ID:UBP18_HUMAN; ENSEMBL ID: ENSG00000184979; HGNC ID: 12616
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult58 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor11 / 26384541
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal67 / 336030719
ovarian tumor3 / 7668239
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain14 / 110098912
cervix1 / 4817120
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye0 / 2110540 
heart4 / 8962644
intestine6 / 23447225
kidney4 / 21177718
larynx2 / 2414582
liver6 / 20774328
lung15 / 33697444
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta5 / 28082517
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach0 / 966190 
testis6 / 33044218
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219211_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.5
Adipocyte6.15
AdrenalCortex5.75
Adrenalgland4.65
Amygdala5.65
Appendix5.5
AtrioventricularNode4.35
BDCA4+_DentriticCells6.2
Bonemarrow5.4
BronchialEpithelialCells5.45
CD105+_Endothelial5.7
CD14+_Monocytes5.8
CD19+_BCells(neg._sel.)5.95
CD33+_Myeloid6.8
CD34+7.25
CD4+_Tcells6.1
CD56+_NKCells6.65
CD71+_EarlyErythroid5.1
CD8+_Tcells5.45
CardiacMyocytes7
Caudatenucleus4.9
Cerebellum4.4
CerebellumPeduncles6.2
CiliaryGanglion3.95
CingulateCortex5.6
Colorectaladenocarcinoma5.35
DorsalRootGanglion4.4
FetalThyroid5.5
Fetalbrain5.35
Fetalliver4.85
Fetallung4.55
GlobusPallidus4
Heart7
Hypothalamus5.85
Kidney4.55
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)5.2
Liver7.45
Lung6.1
Lymphnode4.75
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)7.65
MedullaOblongata5
OccipitalLobe4.95
OlfactoryBulb4.35
Ovary3.65
Pancreas4.4
PancreaticIslet5.85
ParietalLobe5.75
Pituitary6.4
Placenta5.65
Pons5.2
PrefrontalCortex6.55
Prostate6.45
Salivarygland4.4
SkeletalMuscle6.35
Skin4.2
SmoothMuscle6.2
Spinalcord5.85
SubthalamicNucleus5
SuperiorCervicalGanglion6.2
TemporalLobe5.05
Testis8.55
TestisGermCell8.7
TestisIntersitial7.4
TestisLeydigCell6.75
TestisSeminiferousTubule6.05
Thalamus5.55
Thymus4.4
Thyroid6.95
Tongue5.3
Tonsil5.35
Trachea4.6
TrigeminalGanglion5.45
Uterus4.4
UterusCorpus4.9
WholeBlood6.05
Wholebrain4.7
colon5.5
pineal_day6.86
pineal_night6.64
retina6.7
small_intestine5.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P132159
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.43 ± 0.7
Basal Forebrain3.56 ± 0.86
Basal Part of Pons3.05 ± 0.37
Cerebellar Cortex3.16 ± 0.46
Cerebellar Nuclei3.45 ± 0.63
Claustrum3.23 ± 0.61
Epithalamus4.35 ± 0.41
Frontal Lobe3.58 ± 0.62
Globus Pallidus4.21 ± 0.41
Hypothalamus3.51 ± 0.84
Insula3.59 ± 0.41
Limbic Lobe3.55 ± 0.64
Mesencephalon3.81 ± 0.69
Myelencephalon3.75 ± 0.71
Occipital Lobe3.8 ± 0.72
Parietal Lobe3.5 ± 0.68
Pontine Tegmentum3.7 ± 0.6
Striatum4.2 ± 0.47
Subthalamus3.32 ± 0.29
Temporal Lobe3.76 ± 0.57
Thalamus3.66 ± 0.62
White Matter2.1 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp18CBCerebellum3.71
4.57
Usp18CTXCerebral cortex0.58
0.69
Usp18HIPHippocampal region0.69
0.82
Usp18HPFHippocampal formation0.65
0.79
Usp18HYHypothalamus0.29
0.23
Usp18LSXLateral septal complex0.2
0.37
Usp18MBMidbrain1.07
1.23
Usp18MYMedulla1.69
1.9
Usp18OLFOlfactory bulb1.59
1.83
Usp18PPons1.38
1.66
Usp18PALPallidum0.19
0.12
Usp18RHPRetrohippocampal region0.57
0.68
Usp18sAMYStriatum-like amygdalar nuclei0.09
0.14
Usp18STRStriatum0.24
0.28
Usp18STRdStriatum dorsal region0.3
0.36
Usp18STRvStriatum ventral region0.08
0.06
Usp18THThalamus0.95
1.09
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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