AutismKB 2.0

Annotation Detail for CHRNA7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CHRNA7 ( CHRNA7-2,NACHRA7 )
Gene Full Name: cholinergic receptor, nicotinic, alpha 7
Band: 15q13.3
Quick LinksEntrez ID:1139; OMIM: 118511; Uniprot ID:ACHA7_HUMAN; ENSEMBL ID: ENSG00000175344; HGNC ID: 1960
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult4 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal16 / 33603074
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine2 / 2344728
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve2 / 15768126
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210123_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.2
Adipocyte6.1
AdrenalCortex6.85
Adrenalgland5.15
Amygdala6.6
Appendix6.1
AtrioventricularNode4.55
BDCA4+_DentriticCells7.5
Bonemarrow6
BronchialEpithelialCells6.15
CD105+_Endothelial6.25
CD14+_Monocytes6.65
CD19+_BCells(neg._sel.)7.65
CD33+_Myeloid8
CD34+9.6
CD4+_Tcells6.85
CD56+_NKCells7.5
CD71+_EarlyErythroid5.75
CD8+_Tcells5.85
CardiacMyocytes7.65
Caudatenucleus5.55
Cerebellum5
CerebellumPeduncles6.95
CiliaryGanglion4.25
CingulateCortex6.35
Colorectaladenocarcinoma6.1
DorsalRootGanglion4.6
FetalThyroid6
Fetalbrain6.2
Fetalliver5.25
Fetallung5.2
GlobusPallidus4.75
Heart7.7
Hypothalamus6.7
Kidney4.9
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-605.4
Leukemialymphoblastic(MOLT-4)5
Liver8
Lung6.85
Lymphnode5.4
Lymphoma_burkitts(Daudi)7.8
Lymphoma_burkitts(Raji)8.5
MedullaOblongata5.7
OccipitalLobe5.55
OlfactoryBulb4.8
Ovary4.05
Pancreas4.9
PancreaticIslet6.6
ParietalLobe6.4
Pituitary7.2
Placenta6.45
Pons5.9
PrefrontalCortex7.85
Prostate8.9
Salivarygland4.9
SkeletalMuscle7.4
Skin4.65
SmoothMuscle7.05
Spinalcord6.6
SubthalamicNucleus6.4
SuperiorCervicalGanglion6.8
TemporalLobe5.6
Testis7.05
TestisGermCell5.75
TestisIntersitial5.3
TestisLeydigCell6.05
TestisSeminiferousTubule5.35
Thalamus6.3
Thymus4.9
Thyroid7.85
Tongue6
Tonsil6
Trachea5.15
TrigeminalGanglion6
Uterus5.1
UterusCorpus5.5
WholeBlood6.5
Wholebrain6.55
colon6.2
pineal_day7.48
pineal_night7.82
retina7.575
small_intestine5.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_681_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.43 ± 0.7
Basal Forebrain2.52 ± 0.71
Basal Part of Pons2.31 ± 0.55
Cerebellar Cortex2.57 ± 0.68
Cerebellar Nuclei2.64 ± 0.74
Claustrum3.4 ± 1.1
Epithalamus2.72 ± 1.14
Frontal Lobe2.82 ± 0.75
Globus Pallidus2.04 ± 0.61
Hypothalamus3.27 ± 0.6
Insula3.16 ± 0.44
Limbic Lobe3.02 ± 0.73
Mesencephalon2.84 ± 0.68
Myelencephalon3.02 ± 0.76
Occipital Lobe3.17 ± 0.74
Parietal Lobe2.92 ± 0.79
Pontine Tegmentum3.09 ± 0.79
Striatum2.87 ± 0.73
Subthalamus2.52 ± 0.64
Temporal Lobe3.12 ± 0.7
Thalamus2.96 ± 0.66
White Matter1.77 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Chrna7CBCerebellum1.57
2.2
Chrna7CTXCerebral cortex6.04
5.67
Chrna7HIPHippocampal region23.39
37.35
Chrna7HPFHippocampal formation15.51
22.04
Chrna7HYHypothalamus2.58
2.7
Chrna7LSXLateral septal complex0.76
0.79
Chrna7MBMidbrain7.82
8.63
Chrna7MYMedulla5.01
7.45
Chrna7OLFOlfactory bulb6.51
6.53
Chrna7PPons6.6
8.07
Chrna7PALPallidum2.32
3.12
Chrna7RHPRetrohippocampal region6.5
7.06
Chrna7sAMYStriatum-like amygdalar nuclei6.57
8.17
Chrna7STRStriatum1.77
1.86
Chrna7STRdStriatum dorsal region1.18
1.1
Chrna7STRvStriatum ventral region1.29
1.16
Chrna7THThalamus1.94
2.56
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved