AutismKB 2.0

Annotation Detail for MAL2


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Basic Information Top
Gene Symbol:MAL2 ( - )
Gene Full Name: mal, T-cell differentiation protein 2
Band: 8q24.12
Quick LinksEntrez ID:114569; OMIM: 609684; Uniprot ID:MAL2_HUMAN; ENSEMBL ID: ENSG00000147676; HGNC ID: 13634
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus28 / 56401249
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult219 / 1939121112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma7 / 17475400
breast (mammary gland) tumor14 / 94178148
cervical tumor4 / 34366116
chondrosarcoma2 / 8282324
colorectal tumor80 / 114246700
esophageal tumor3 / 17290173
gastrointestinal tumor38 / 119369318
germ cell tumor21 / 26384579
glioma0 / 1068830 
head and neck tumor16 / 136302117
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor18 / 96359186
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia9 / 9725092
normal150 / 336030744
ovarian tumor13 / 76682169
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer22 / 102680214
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites9 / 40015224
bladder13 / 29757436
blood0 / 1234780 
bone0 / 716550 
bone marrow3 / 4880161
brain35 / 110098931
cervix5 / 48171103
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus3 / 20209148
eye8 / 21105437
heart4 / 8962644
intestine101 / 234472430
kidney11 / 21177751
larynx1 / 2414541
liver20 / 20774396
lung25 / 33697474
lymph1 / 4427022
lymph node11 / 91610120
mammary gland15 / 15327197
mouth5 / 6705274
muscle0 / 1077150 
nerve0 / 157680 
ovary15 / 102051146
pancreas16 / 21481274
parathyroid7 / 20539340
pharynx4 / 4132896
pituitary gland0 / 165850 
placenta21 / 28082574
prostate28 / 189345147
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach31 / 96619320
testis6 / 33044218
thymus0 / 811310 
thyroid10 / 47473210
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus18 / 23287877
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13749_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.11 ± 0.72
Basal Forebrain6.35 ± 0.51
Basal Part of Pons6.66 ± 0.59
Cerebellar Cortex7.44 ± 0.25
Cerebellar Nuclei5.55 ± 0.52
Claustrum6.82 ± 0.47
Epithalamus6.35 ± 0.93
Frontal Lobe7.34 ± 0.57
Globus Pallidus4.63 ± 0.54
Hypothalamus6.49 ± 0.52
Insula7.23 ± 0.49
Limbic Lobe7.5 ± 0.82
Mesencephalon6.78 ± 0.81
Myelencephalon7.09 ± 0.63
Occipital Lobe6.92 ± 0.85
Parietal Lobe7.52 ± 0.56
Pontine Tegmentum7.01 ± 0.77
Striatum6.19 ± 0.88
Subthalamus6.52 ± 0.49
Temporal Lobe7.52 ± 0.5
Thalamus7.62 ± 0.68
White Matter4.6 ± 0.7
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mal2CBCerebellum18.15
19.16
Mal2CTXCerebral cortex100
100
Mal2HIPHippocampal region58.69
100
Mal2HPFHippocampal formation72.74
100
Mal2HYHypothalamus10.28
8.71
Mal2LSXLateral septal complex14.97
12.75
Mal2MBMidbrain11.67
12.2
Mal2MYMedulla14.62
15.23
Mal2OLFOlfactory bulb76.27
87.02
Mal2PPons12.98
12.42
Mal2PALPallidum13.09
11.31
Mal2RHPRetrohippocampal region89.71
100
Mal2sAMYStriatum-like amygdalar nuclei15.05
12.41
Mal2STRStriatum24.43
19.34
Mal2STRdStriatum dorsal region30.31
24.13
Mal2STRvStriatum ventral region14.93
11.31
Mal2THThalamus20.83
20.47
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018