AutismKB 2.0

Annotation Detail for OSBPL8


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Basic Information Top
Gene Symbol:OSBPL8 ( DKFZp686A11164,MGC126578,MGC133203,MST120,MSTP120,ORP8,OSBP10 )
Gene Full Name: oxysterol binding protein-like 8
Band: 12q14
Quick LinksEntrez ID:114882; OMIM: 606736; Uniprot ID:OSBL8_HUMAN; ENSEMBL ID: ENSG00000091039; HGNC ID: 16396
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst2 / 6231932
fetus62 / 564012109
neonate2 / 3109764
infant1 / 2362042
juvenile6 / 55556107
adult135 / 193912169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor3 / 17290173
gastrointestinal tumor6 / 11936950
germ cell tumor31 / 263845117
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor5 / 6895972
leukemia9 / 9584293
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma7 / 7175597
non-neoplasia5 / 9725051
normal276 / 336030782
ovarian tumor2 / 7668226
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites5 / 40015124
bladder2 / 2975767
blood9 / 12347872
bone5 / 7165569
bone marrow8 / 48801163
brain49 / 110098944
cervix1 / 4817120
connective tissue5 / 14925533
ear2 / 16212123
embryonic tissue17 / 21572278
esophagus3 / 20209148
eye9 / 21105442
heart1 / 8962611
intestine9 / 23447238
kidney29 / 211777136
larynx2 / 2414582
liver15 / 20774372
lung24 / 33697471
lymph5 / 44270112
lymph node27 / 91610294
mammary gland18 / 153271117
mouth0 / 670520 
muscle10 / 10771592
nerve1 / 1576863
ovary1 / 1020519
pancreas17 / 21481279
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta20 / 28082571
prostate15 / 18934579
salivary gland0 / 201550 
skin9 / 21057442
spleen3 / 5395255
stomach2 / 9661920
testis18 / 33044254
thymus9 / 81131110
thyroid0 / 474730 
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus29 / 232878124
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212585_at
Cell line Expression level Expression bar
721_B_lymphoblasts137.8
Adipocyte131.8
AdrenalCortex14.45
Adrenalgland11.7
Amygdala193.65
Appendix20.05
AtrioventricularNode16
BDCA4+_DentriticCells364.55
Bonemarrow14.1
BronchialEpithelialCells106.7
CD105+_Endothelial178.1
CD14+_Monocytes421.05
CD19+_BCells(neg._sel.)170.35
CD33+_Myeloid354.15
CD34+218.9
CD4+_Tcells329.15
CD56+_NKCells438.8
CD71+_EarlyErythroid69.45
CD8+_Tcells287.3
CardiacMyocytes39.9
Caudatenucleus179.85
Cerebellum11.95
CerebellumPeduncles16.8
CiliaryGanglion16.95
CingulateCortex24.75
Colorectaladenocarcinoma83.15
DorsalRootGanglion20.8
FetalThyroid17.5
Fetalbrain231.65
Fetalliver34.75
Fetallung77.15
GlobusPallidus16.35
Heart23.2
Hypothalamus63.85
Kidney14.1
Leukemia_chronicMyelogenousK-56265.3
Leukemia_promyelocytic-HL-60309.6
Leukemialymphoblastic(MOLT-4)78.85
Liver14.65
Lung14
Lymphnode111.4
Lymphoma_burkitts(Daudi)39.5
Lymphoma_burkitts(Raji)397.55
MedullaOblongata59.7
OccipitalLobe84.45
OlfactoryBulb28.95
Ovary10.15
Pancreas15
PancreaticIslet36.25
ParietalLobe30.6
Pituitary26.7
Placenta7.15
Pons17.1
PrefrontalCortex172.75
Prostate31.2
Salivarygland29.9
SkeletalMuscle14.5
Skin23.15
SmoothMuscle120.65
Spinalcord63.1
SubthalamicNucleus19.3
SuperiorCervicalGanglion20.8
TemporalLobe14.45
Testis6.4
TestisGermCell18.45
TestisIntersitial14
TestisLeydigCell12.4
TestisSeminiferousTubule10.7
Thalamus20.8
Thymus18.3
Thyroid98.05
Tongue18.25
Tonsil37.35
Trachea27.2
TrigeminalGanglion18.05
Uterus112
UterusCorpus49.2
WholeBlood887.3
Wholebrain38.1
colon21.1
pineal_day38.8
pineal_night33.22
retina26.975
small_intestine16.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P204810
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.01 ± 0.2
Basal Forebrain10.14 ± 0.19
Basal Part of Pons9.67 ± 0.22
Cerebellar Cortex9.59 ± 0.1
Cerebellar Nuclei9.57 ± 0.23
Claustrum9.95 ± 0.23
Epithalamus10.05 ± 0.22
Frontal Lobe9.87 ± 0.27
Globus Pallidus9.47 ± 0.33
Hypothalamus9.84 ± 0.25
Insula9.87 ± 0.19
Limbic Lobe9.92 ± 0.26
Mesencephalon9.84 ± 0.35
Myelencephalon9.83 ± 0.35
Occipital Lobe9.76 ± 0.3
Parietal Lobe9.81 ± 0.29
Pontine Tegmentum9.92 ± 0.37
Striatum10.93 ± 0.34
Subthalamus9.59 ± 0.15
Temporal Lobe9.78 ± 0.19
Thalamus9.79 ± 0.29
White Matter9.54 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Osbpl8CBCerebellum21.02
22.09
Osbpl8CTXCerebral cortex94.43
94.23
Osbpl8HIPHippocampal region45.69
77.98
Osbpl8HPFHippocampal formation57.63
80.65
Osbpl8HYHypothalamus11.28
9.92
Osbpl8LSXLateral septal complex46.46
41.34
Osbpl8MBMidbrain15.46
15.41
Osbpl8MYMedulla27.21
32.45
Osbpl8OLFOlfactory bulb80.97
84.29
Osbpl8PPons17.88
21.21
Osbpl8PALPallidum33.4
38.1
Osbpl8RHPRetrohippocampal region75.57
83.18
Osbpl8sAMYStriatum-like amygdalar nuclei60.61
56.73
Osbpl8STRStriatum100
100
Osbpl8STRdStriatum dorsal region100
100
Osbpl8STRvStriatum ventral region100
100
Osbpl8THThalamus45.72
44.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040064 20 280 299 EHDLSVSSDSTHVTFYGLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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