AutismKB 2.0

Annotation Detail for GPR146


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Basic Information Top
Gene Symbol:GPR146 ( PGR8 )
Gene Full Name: G protein-coupled receptor 146
Band: 7p22.3
Quick LinksEntrez ID:115330; OMIM: NA; Uniprot ID:GP146_HUMAN; ENSEMBL ID: ENSG00000164849; HGNC ID: 21718
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus8 / 56401214
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult21 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal37 / 336030711
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain9 / 11009898
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney5 / 21177723
larynx0 / 241450 
liver2 / 2077439
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis2 / 3304426
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5780_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.94 ± 0.97
Basal Forebrain3.93 ± 0.69
Basal Part of Pons3.74 ± 0.58
Cerebellar Cortex3.73 ± 0.68
Cerebellar Nuclei4.19 ± 0.7
Claustrum4.07 ± 0.8
Epithalamus3.68 ± 0.52
Frontal Lobe3.76 ± 0.61
Globus Pallidus4.72 ± 0.57
Hypothalamus3.42 ± 0.63
Insula3.96 ± 0.99
Limbic Lobe3.69 ± 0.7
Mesencephalon4.04 ± 0.58
Myelencephalon3.92 ± 0.73
Occipital Lobe4.28 ± 0.61
Parietal Lobe3.8 ± 0.79
Pontine Tegmentum3.88 ± 0.74
Striatum4.06 ± 0.71
Subthalamus4.02 ± 0.44
Temporal Lobe3.78 ± 0.68
Thalamus4.14 ± 0.61
White Matter4.45 ± 1.02
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gpr146CBCerebellum2.66
2.02
Gpr146CTXCerebral cortex1.95
1.36
Gpr146HIPHippocampal region1.4
0.81
Gpr146HPFHippocampal formation1.18
0.69
Gpr146HYHypothalamus0.29
0.22
Gpr146LSXLateral septal complex0.47
0.41
Gpr146MBMidbrain0.49
0.45
Gpr146MYMedulla1.1
0.87
Gpr146OLFOlfactory bulb3.92
2.91
Gpr146PPons0.93
1.09
Gpr146PALPallidum0.37
0.26
Gpr146RHPRetrohippocampal region0.56
0.37
Gpr146sAMYStriatum-like amygdalar nuclei1.83
1.3
Gpr146STRStriatum0.85
0.53
Gpr146STRdStriatum dorsal region0.71
0.42
Gpr146STRvStriatum ventral region0.62
0.37
Gpr146THThalamus0.3
0.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018