AutismKB 2.0

Annotation Detail for LRRC42


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Basic Information Top
Gene Symbol:LRRC42 ( MGC8974,dJ167A19.4 )
Gene Full Name: leucine rich repeat containing 42
Band: 1p32.3
Quick LinksEntrez ID:115353; OMIM: NA; Uniprot ID:LRC42_HUMAN; ENSEMBL ID: ENSG00000116212; HGNC ID: 28792
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst0 / 623190 
fetus16 / 56401228
neonate1 / 3109732
infant2 / 2362084
juvenile4 / 5555671
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia8 / 9584283
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma6 / 7175583
non-neoplasia0 / 972500 
normal93 / 336030727
ovarian tumor1 / 7668213
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites2 / 4001549
bladder2 / 2975767
blood10 / 12347880
bone7 / 7165597
bone marrow0 / 488010 
brain13 / 110098911
cervix4 / 4817183
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye5 / 21105423
heart0 / 896260 
intestine4 / 23447217
kidney5 / 21177723
larynx0 / 241450 
liver13 / 20774362
lung4 / 33697411
lymph0 / 442700 
lymph node3 / 9161032
mammary gland2 / 15327113
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta19 / 28082567
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach1 / 9661910
testis6 / 33044218
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus8 / 23287834
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 215084_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts16.2
Adipocyte7.15
AdrenalCortex5.8
Adrenalgland4.85
Amygdala5.95
Appendix5.6
AtrioventricularNode4.35
BDCA4+_DentriticCells5.9
Bonemarrow5.7
BronchialEpithelialCells63
CD105+_Endothelial5.6
CD14+_Monocytes5.1
CD19+_BCells(neg._sel.)5.45
CD33+_Myeloid5.9
CD34+7.15
CD4+_Tcells5.9
CD56+_NKCells6.25
CD71+_EarlyErythroid5.35
CD8+_Tcells5
CardiacMyocytes8.05
Caudatenucleus5.15
Cerebellum4.55
CerebellumPeduncles6.4
CiliaryGanglion3.9
CingulateCortex5.75
Colorectaladenocarcinoma41.7
DorsalRootGanglion4.3
FetalThyroid5.5
Fetalbrain5.9
Fetalliver5.8
Fetallung5.05
GlobusPallidus4.1
Heart7.4
Hypothalamus6.15
Kidney4.65
Leukemia_chronicMyelogenousK-56211.5
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)5.6
Liver7.5
Lung6.2
Lymphnode4.75
Lymphoma_burkitts(Daudi)7.45
Lymphoma_burkitts(Raji)7.85
MedullaOblongata5.2
OccipitalLobe5.1
OlfactoryBulb4.5
Ovary3.75
Pancreas5.45
PancreaticIslet6.45
ParietalLobe5.9
Pituitary7.5
Placenta16.15
Pons5.35
PrefrontalCortex6.8
Prostate8.2
Salivarygland4.35
SkeletalMuscle6.5
Skin4.3
SmoothMuscle26.5
Spinalcord6.1
SubthalamicNucleus5.1
SuperiorCervicalGanglion6.55
TemporalLobe5.15
Testis5.5
TestisGermCell6.1
TestisIntersitial4.95
TestisLeydigCell5.6
TestisSeminiferousTubule5.15
Thalamus5.55
Thymus4.45
Thyroid7.95
Tongue5.5
Tonsil5.45
Trachea4.65
TrigeminalGanglion5.55
Uterus4.65
UterusCorpus5.25
WholeBlood5.85
Wholebrain4.9
colon5.75
pineal_day6.56
pineal_night6.6
retina7.225
small_intestine5.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P276791
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.11 ± 0.65
Basal Forebrain3.56 ± 0.82
Basal Part of Pons3.66 ± 0.7
Cerebellar Cortex3.64 ± 0.54
Cerebellar Nuclei3.41 ± 0.55
Claustrum3.72 ± 0.76
Epithalamus3.91 ± 0.31
Frontal Lobe3.63 ± 0.52
Globus Pallidus3.45 ± 0.87
Hypothalamus3.68 ± 0.48
Insula3.66 ± 0.43
Limbic Lobe3.9 ± 0.48
Mesencephalon3.69 ± 0.67
Myelencephalon3.76 ± 0.51
Occipital Lobe3.55 ± 0.81
Parietal Lobe3.75 ± 0.56
Pontine Tegmentum3.72 ± 0.61
Striatum3.77 ± 0.62
Subthalamus3.46 ± 0.74
Temporal Lobe3.85 ± 0.5
Thalamus3.57 ± 0.62
White Matter4.01 ± 0.9
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrrc42CBCerebellum0.73
1.38
Lrrc42CTXCerebral cortex1.19
1.3
Lrrc42HIPHippocampal region11.05
10.38
Lrrc42HPFHippocampal formation9.42
8.43
Lrrc42HYHypothalamus2.85
2.63
Lrrc42LSXLateral septal complex0.21
0.3
Lrrc42MBMidbrain0.69
0.89
Lrrc42MYMedulla0.63
1.38
Lrrc42OLFOlfactory bulb9
7.62
Lrrc42PPons1.89
3.57
Lrrc42PALPallidum0.79
0.78
Lrrc42RHPRetrohippocampal region4.89
4.41
Lrrc42sAMYStriatum-like amygdalar nuclei4.49
3.36
Lrrc42STRStriatum1.78
1.36
Lrrc42STRdStriatum dorsal region0.61
0.47
Lrrc42STRvStriatum ventral region4.72
3.21
Lrrc42THThalamus4.87
5.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00133087 25 185 209 LGDEHELLEHLTNEALSSVTQLHLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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