Annotation Detail for CISH
Basic Information Top
| Gene Symbol: | CISH ( CIS,CIS-1,G18,SOCS ) |
|---|---|
| Gene Full Name: | cytokine inducible SH2-containing protein |
| Band: | 3p21.2 |
| Quick Links | Entrez ID:1154; OMIM: 602441; Uniprot ID:CISH_HUMAN; ENSEMBL ID: ENSG00000114737; HGNC ID: 1984 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.655334
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 3 / 564012 | 5 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 84 / 1939121 | 43 |  |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 2 / 82823 | 24 | |
| colorectal tumor | 2 / 114246 | 17 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 8 / 263845 | 30 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 4 / 95842 | 41 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 78 / 3360307 | 23 | |
| ovarian tumor | 7 / 76682 | 91 |  |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 3 / 125680 | 23 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 5 / 90257 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 5 / 123478 | 40 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 4 / 48801 | 81 | |
| brain | 5 / 1100989 | 4 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 2 / 149255 | 13 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 2 / 234472 | 8 | |
| kidney | 5 / 211777 | 23 | |
| larynx | 1 / 24145 | 41 | |
| liver | 0 / 207743 | 0 | |
| lung | 3 / 336974 | 8 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 2 / 91610 | 21 | |
| mammary gland | 6 / 153271 | 39 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 10 / 102051 | 97 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 1 / 20539 | 48 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 23 / 280825 | 81 | |
| prostate | 3 / 189345 | 15 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 1 / 210574 | 4 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 0 / 96619 | 0 | |
| testis | 1 / 330442 | 3 | |
| thymus | 1 / 81131 | 12 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 5 / 232878 | 21 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 221223_x_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.5 | |
| Adipocyte | 3.9 | |
| AdrenalCortex | 4.1 | |
| Adrenalgland | 3.35 | |
| Amygdala | 4.35 | |
| Appendix | 4.05 | |
| AtrioventricularNode | 2.95 | |
| BDCA4+_DentriticCells | 4.45 | |
| Bonemarrow | 6.6 | |
| BronchialEpithelialCells | 3.95 | |
| CD105+_Endothelial | 5.6 | |
| CD14+_Monocytes | 4.4 | |
| CD19+_BCells(neg._sel.) | 4.05 | |
| CD33+_Myeloid | 5.1 | |
| CD34+ | 4.95 | |
| CD4+_Tcells | 31.95 | |
| CD56+_NKCells | 5 | |
| CD71+_EarlyErythroid | 3.75 | |
| CD8+_Tcells | 30.05 | |
| CardiacMyocytes | 5.35 | |
| Caudatenucleus | 3.5 | |
| Cerebellum | 3.3 | |
| CerebellumPeduncles | 7.35 | |
| CiliaryGanglion | 2.75 | |
| CingulateCortex | 4.05 | |
| Colorectaladenocarcinoma | 4.55 | |
| DorsalRootGanglion | 4.3 | |
| FetalThyroid | 8.25 | |
| Fetalbrain | 4.5 | |
| Fetalliver | 4.25 | |
| Fetallung | 16.1 | |
| GlobusPallidus | 2.8 | |
| Heart | 18.2 | |
| Hypothalamus | 4.45 | |
| Kidney | 6.55 | |
| Leukemia_chronicMyelogenousK-562 | 115.1 | |
| Leukemia_promyelocytic-HL-60 | 3.55 | |
| Leukemialymphoblastic(MOLT-4) | 4.05 | |
| Liver | 6.15 | |
| Lung | 90.65 | |
| Lymphnode | 3.95 | |
| Lymphoma_burkitts(Daudi) | 5.1 | |
| Lymphoma_burkitts(Raji) | 6.05 | |
| MedullaOblongata | 3.65 | |
| OccipitalLobe | 3.65 | |
| OlfactoryBulb | 3.1 | |
| Ovary | 4.1 | |
| Pancreas | 3.35 | |
| PancreaticIslet | 7.15 | |
| ParietalLobe | 4.2 | |
| Pituitary | 8.5 | |
| Placenta | 90.5 | |
| Pons | 4.5 | |
| PrefrontalCortex | 4.9 | |
| Prostate | 5.75 | |
| Salivarygland | 3.2 | |
| SkeletalMuscle | 5 | |
| Skin | 3.25 | |
| SmoothMuscle | 4.55 | |
| Spinalcord | 4.15 | |
| SubthalamicNucleus | 3.5 | |
| SuperiorCervicalGanglion | 7.55 | |
| TemporalLobe | 3.6 | |
| Testis | 4.45 | |
| TestisGermCell | 3.5 | |
| TestisIntersitial | 3.9 | |
| TestisLeydigCell | 3.95 | |
| TestisSeminiferousTubule | 3.55 | |
| Thalamus | 3.9 | |
| Thymus | 4.85 | |
| Thyroid | 11.7 | |
| Tongue | 5.35 | |
| Tonsil | 4.35 | |
| Trachea | 3.6 | |
| TrigeminalGanglion | 3.9 | |
| Uterus | 3.75 | |
| UterusCorpus | 6.7 | |
| WholeBlood | 15.15 | |
| Wholebrain | 4.05 | |
| colon | 3.9 | |
| pineal_day | 4.74 | |
| pineal_night | 4.76 | |
| retina | 4.725 | |
| small_intestine | 3.75 | |
- Probe name: A_23_P144096
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.7 ± 1.13 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.42 ± 0.74 | |
| Basal Part of Pons | 5.77 ± 1.34 | |
| Cerebellar Cortex | 5.52 ± 0.6 | |
| Cerebellar Nuclei | 5.5 ± 1.25 | |
| Claustrum | 7.33 ± 1.16 | |
| Epithalamus | 5.12 ± 1.22 | |
| Frontal Lobe | 5.29 ± 1.13 | |
| Globus Pallidus | 7.73 ± 0.95 | |
| Hypothalamus | 5.22 ± 0.97 | |
| Insula | 5.55 ± 1.11 | |
| Limbic Lobe | 6.29 ± 1.32 | |
| Mesencephalon | 6.13 ± 1.01 | |
| Myelencephalon | 6 ± 1.31 | |
| Occipital Lobe | 6.48 ± 1.06 | |
| Parietal Lobe | 6.06 ± 1.19 | |
| Pontine Tegmentum | 5.77 ± 1.24 | |
| Striatum | 6.54 ± 1.52 | |
| Subthalamus | 6.74 ± 0.74 | |
| Temporal Lobe | 5.75 ± 1.28 | |
| Thalamus | 5.65 ± 0.98 | |
| White Matter | 7.26 ± 1.44 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Cish | CB | Cerebellum | 4.74 | |
| 5.68 | | |||
| Cish | CTX | Cerebral cortex | 5.94 | |
| 3.4 | | |||
| Cish | HIP | Hippocampal region | 4.38 | |
| 4.19 | | |||
| Cish | HPF | Hippocampal formation | 4.67 | |
| 3.77 | | |||
| Cish | HY | Hypothalamus | 4.36 | |
| 2.62 | | |||
| Cish | LSX | Lateral septal complex | 3.35 | |
| 2.27 | | |||
| Cish | MB | Midbrain | 2.69 | |
| 2.36 | | |||
| Cish | MY | Medulla | 8.25 | |
| 8.32 | | |||
| Cish | OLF | Olfactory bulb | 8.95 | |
| 5.49 | | |||
| Cish | P | Pons | 10.21 | |
| 8.58 | | |||
| Cish | PAL | Pallidum | 1.75 | |
| 1.31 | | |||
| Cish | RHP | Retrohippocampal region | 5.27 | |
| 3.28 | | |||
| Cish | sAMY | Striatum-like amygdalar nuclei | 2.73 | |
| 1.81 | | |||
| Cish | STR | Striatum | 6.53 | |
| 3.92 | | |||
| Cish | STRd | Striatum dorsal region | 7.19 | |
| 4.06 | | |||
| Cish | STRv | Striatum ventral region | 7.41 | |
| 4.96 | | |||
| Cish | TH | Thalamus | 7.84 | |
| 5.89 | |
Peptide