AutismKB 2.0

Annotation Detail for DIS3L


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Basic Information Top
Gene Symbol:DIS3L ( FLJ38088,KIAA1955,MGC4562 )
Gene Full Name: DIS3 mitotic control homolog (S. cerevisiae)-like
Band: 15q22.31
Quick LinksEntrez ID:115752; OMIM: NA; Uniprot ID:DI3L1_HUMAN; ENSEMBL ID: ENSG00000166938; HGNC ID: 28698
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus6 / 56401210
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult41 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor8 / 34366232
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma2 / 10688318
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor6 / 9635962
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal58 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone3 / 7165541
bone marrow1 / 4880120
brain23 / 110098920
cervix8 / 48171166
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye8 / 21105437
heart0 / 896260 
intestine4 / 23447217
kidney3 / 21177714
larynx0 / 241450 
liver8 / 20774338
lung4 / 33697411
lymph0 / 442700 
lymph node2 / 9161021
mammary gland8 / 15327152
mouth3 / 6705244
muscle9 / 10771583
nerve0 / 157680 
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen2 / 5395237
stomach1 / 9661910
testis5 / 33044215
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P65741
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.09 ± 0.47
Basal Forebrain7.53 ± 0.14
Basal Part of Pons7.49 ± 0.29
Cerebellar Cortex7.59 ± 0.23
Cerebellar Nuclei7.68 ± 0.22
Claustrum6.83 ± 0.55
Epithalamus7.6 ± 0.34
Frontal Lobe7.59 ± 0.32
Globus Pallidus8.03 ± 0.23
Hypothalamus7.77 ± 0.23
Insula7.52 ± 0.26
Limbic Lobe7.35 ± 0.39
Mesencephalon7.42 ± 0.38
Myelencephalon7.45 ± 0.39
Occipital Lobe7.1 ± 0.46
Parietal Lobe7.43 ± 0.31
Pontine Tegmentum7.56 ± 0.35
Striatum7.29 ± 0.33
Subthalamus7.14 ± 0.52
Temporal Lobe7.57 ± 0.36
Thalamus7.57 ± 0.28
White Matter8.29 ± 0.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AV340375CBCerebellum4.32
3.88
AV340375CTXCerebral cortex1.56
1.2
AV340375HIPHippocampal region4.65
3.97
AV340375HPFHippocampal formation4.53
3.49
AV340375HYHypothalamus1.42
0.98
AV340375LSXLateral septal complex0.31
0.25
AV340375MBMidbrain2.66
2.61
AV340375MYMedulla9.37
10.13
AV340375OLFOlfactory bulb4.78
3.39
AV340375PPons6.19
6.07
AV340375PALPallidum2.1
1.74
AV340375RHPRetrohippocampal region4.31
2.74
AV340375sAMYStriatum-like amygdalar nuclei2.12
1.3
AV340375STRStriatum1
0.66
AV340375STRdStriatum dorsal region0.62
0.46
AV340375STRvStriatum ventral region2
1.13
AV340375THThalamus1.69
1.3
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018