Annotation Detail for TOP1MT
Basic Information Top
| Gene Symbol: | TOP1MT ( - ) |
|---|---|
| Gene Full Name: | topoisomerase (DNA) I, mitochondrial |
| Band: | 8q24.3 |
| Quick Links | Entrez ID:116447; OMIM: 606387; Uniprot ID:TOP1M_HUMAN; ENSEMBL ID: ENSG00000184428; HGNC ID: 29787 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.528574
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 13 / 564012 | 23 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 10 / 55556 | 179 |  |
| adult | 77 / 1939121 | 39 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 14 / 94178 | 148 | |
| cervical tumor | 4 / 34366 | 116 | |
| chondrosarcoma | 3 / 82823 | 36 | |
| colorectal tumor | 4 / 114246 | 35 | |
| esophageal tumor | 3 / 17290 | 173 | |
| gastrointestinal tumor | 7 / 119369 | 58 | |
| germ cell tumor | 18 / 263845 | 68 | |
| glioma | 14 / 106883 | 130 | |
| head and neck tumor | 4 / 136302 | 29 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 9 / 95842 | 93 | |
| liver tumor | 1 / 96359 | 10 |  |
| lung tumor | 12 / 103127 | 116 | |
| lymphoma | 6 / 71755 | 83 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 76 / 3360307 | 22 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 4 / 104616 | 38 | |
| primitive neuroectodermal tumor of the CNS | 33 / 125680 | 262 |  |
| prostate cancer | 6 / 102680 | 58 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 5 / 124949 | 40 | |
| soft tissue/muscle tissue tumor | 7 / 125191 | 55 | |
| uterine tumor | 5 / 90257 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 2 / 40015 | 49 | |
| bladder | 2 / 29757 | 67 | |
| blood | 6 / 123478 | 48 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 6 / 48801 | 122 | |
| brain | 46 / 1100989 | 41 | |
| cervix | 6 / 48171 | 124 | |
| connective tissue | 2 / 149255 | 13 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 3 / 20209 | 148 | |
| eye | 9 / 211054 | 42 | |
| heart | 0 / 89626 | 0 | |
| intestine | 11 / 234472 | 46 | |
| kidney | 2 / 211777 | 9 | |
| larynx | 1 / 24145 | 41 | |
| liver | 2 / 207743 | 9 | |
| lung | 17 / 336974 | 50 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 14 / 153271 | 91 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 4 / 214812 | 18 | |
| parathyroid | 1 / 20539 | 48 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 13 / 280825 | 46 | |
| prostate | 7 / 189345 | 36 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 5 / 210574 | 23 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 4 / 96619 | 41 | |
| testis | 12 / 330442 | 36 | |
| thymus | 6 / 81131 | 73 | |
| thyroid | 2 / 47473 | 42 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 14 / 232878 | 60 | |
| vascular | 1 / 51780 | 19 | |
Microarray in - Probe name: CUST_12285_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.54 ± 0.64 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.76 ± 0.44 | |
| Basal Part of Pons | 5.09 ± 0.7 | |
| Cerebellar Cortex | 4.81 ± 0.55 | |
| Cerebellar Nuclei | 5.32 ± 0.56 | |
| Claustrum | 6.45 ± 0.87 | |
| Epithalamus | 4.49 ± 0.63 | |
| Frontal Lobe | 5.28 ± 0.75 | |
| Globus Pallidus | 6.21 ± 0.6 | |
| Hypothalamus | 4.83 ± 1.1 | |
| Insula | 5.06 ± 0.61 | |
| Limbic Lobe | 5.65 ± 0.83 | |
| Mesencephalon | 5.45 ± 0.74 | |
| Myelencephalon | 5.5 ± 0.76 | |
| Occipital Lobe | 5.43 ± 0.78 | |
| Parietal Lobe | 5.39 ± 0.73 | |
| Pontine Tegmentum | 5.26 ± 0.69 | |
| Striatum | 5.53 ± 0.67 | |
| Subthalamus | 5.28 ± 0.43 | |
| Temporal Lobe | 5.36 ± 0.76 | |
| Thalamus | 5.43 ± 0.61 | |
| White Matter | 6.1 ± 0.39 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Top1mt | CB | Cerebellum | 12.58 | |
| 15.24 | | |||
| Top1mt | CTX | Cerebral cortex | 22.2 | |
| 16.06 | | |||
| Top1mt | HIP | Hippocampal region | 24.4 | |
| 25.5 | | |||
| Top1mt | HPF | Hippocampal formation | 26.43 | |
| 24.34 | | |||
| Top1mt | HY | Hypothalamus | 19.11 | |
| 15.08 | | |||
| Top1mt | LSX | Lateral septal complex | 21.98 | |
| 15.61 | | |||
| Top1mt | MB | Midbrain | 13.7 | |
| 12.7 | | |||
| Top1mt | MY | Medulla | 20.06 | |
| 21.2 | | |||
| Top1mt | OLF | Olfactory bulb | 29.87 | |
| 22.92 | | |||
| Top1mt | P | Pons | 18.43 | |
| 19.57 | | |||
| Top1mt | PAL | Pallidum | 17.83 | |
| 14.97 | | |||
| Top1mt | RHP | Retrohippocampal region | 30.51 | |
| 23.27 | | |||
| Top1mt | sAMY | Striatum-like amygdalar nuclei | 28.68 | |
| 20.42 | | |||
| Top1mt | STR | Striatum | 13.85 | |
| 9.99 | | |||
| Top1mt | STRd | Striatum dorsal region | 11.15 | |
| 8.44 | | |||
| Top1mt | STRv | Striatum ventral region | 13.4 | |
| 8.45 | | |||
| Top1mt | TH | Thalamus | 20.49 | |
| 16.71 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00074783 | 9 | 99 | 107 | MLDHEYTTK | Peptide Atlas |
| TOP1M_HUMAN_112 | 8 | 112 | 119 | KNFFNDWR | PRIDE |