AutismKB 2.0

Annotation Detail for LRG1


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Basic Information Top
Gene Symbol:LRG1 ( HMFT1766,LRG )
Gene Full Name: leucine-rich alpha-2-glycoprotein 1
Band: 19p13.3
Quick LinksEntrez ID:116844; OMIM: 611289; Uniprot ID:A2GL_HUMAN; ENSEMBL ID: ENSG00000171236; HGNC ID: 29480
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult39 / 193912120
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor9 / 9635993
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal61 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood7 / 12347856
bone0 / 716550 
bone marrow1 / 4880120
brain2 / 11009891
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye0 / 2110540 
heart0 / 896260 
intestine6 / 23447225
kidney1 / 2117774
larynx0 / 241450 
liver38 / 207743182
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach5 / 9661951
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_85_PI416383280
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.9 ± 1.1
Basal Forebrain1.65 ± 0.78
Basal Part of Pons1.16 ± 0.59
Cerebellar Cortex1.22 ± 0.7
Cerebellar Nuclei1.76 ± 0.66
Claustrum2.36 ± 0.93
Epithalamus1.14 ± 0.79
Frontal Lobe1.35 ± 0.78
Globus Pallidus2.17 ± 0.57
Hypothalamus1.61 ± 0.72
Insula1.44 ± 0.82
Limbic Lobe1.49 ± 0.81
Mesencephalon1.66 ± 0.91
Myelencephalon1.49 ± 0.76
Occipital Lobe1.31 ± 0.53
Parietal Lobe1.53 ± 0.99
Pontine Tegmentum1.59 ± 0.86
Striatum1.77 ± 0.91
Subthalamus1.48 ± 0.7
Temporal Lobe1.42 ± 0.82
Thalamus1.48 ± 0.74
White Matter1.86 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrg1CBCerebellum2.47
4.23
Lrg1CTXCerebral cortex3.83
3.26
Lrg1HIPHippocampal region1.89
2.25
Lrg1HPFHippocampal formation1.6
2.34
Lrg1HYHypothalamus0.13
0.15
Lrg1LSXLateral septal complex0.16
0.23
Lrg1MBMidbrain0.63
1.49
Lrg1MYMedulla0.99
1.64
Lrg1OLFOlfactory bulb1.99
1.71
Lrg1PPons0.39
1.13
Lrg1PALPallidum0.18
0.19
Lrg1RHPRetrohippocampal region1.21
2.43
Lrg1sAMYStriatum-like amygdalar nuclei0.12
0.17
Lrg1STRStriatum0.24
0.25
Lrg1STRdStriatum dorsal region0.27
0.27
Lrg1STRvStriatum ventral region0.23
0.18
Lrg1THThalamus0.9
1.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
A2GL_HUMAN_114 6 114 119 PVPQLR PRIDE
A2GL_HUMAN_149 16 149 164 ENQLEVLEVSWLHGLK PRIDE
A2GL_HUMAN_165 11 165 175 ALGHLDLSGNR PRIDE
A2GL_HUMAN_192 18 192 209 TLDLGENQLETLPPDLLR PRIDE
A2GL_HUMAN_210 7 210 216 GPLQLER PRIDE
A2GL_HUMAN_224 6 224 229 LQVLGK PRIDE
A2GL_HUMAN_230 10 230 239 DLLLPQPDLR PRIDE
A2GL_HUMAN_251 10 251 260 VAAGAFQGLR PRIDE
A2GL_HUMAN_337 9 337 345 GQTLLAVAK PRIDE
PAp00026226 14 178 191 KLPPGLLANFTLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018