AutismKB 2.0

Annotation Detail for AGAP2


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Basic Information Top
Gene Symbol:AGAP2 ( CENTG1,FLJ16430,GGAP2,KIAA0167,PIKE )
Gene Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Band: 12q14.1
Quick LinksEntrez ID:116986; OMIM: 605476; Uniprot ID:AGAP2_HUMAN; ENSEMBL ID: ENSG00000135439; HGNC ID: 16921
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal26 / 33603077
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone2 / 7165527
bone marrow0 / 488010 
brain23 / 110098920
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine1 / 2344724
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph1 / 4427022
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206152_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.65
Adipocyte12
AdrenalCortex23.5
Adrenalgland11
Amygdala19.3
Appendix17.45
AtrioventricularNode27.5
BDCA4+_DentriticCells11.15
Bonemarrow15.35
BronchialEpithelialCells9.35
CD105+_Endothelial11.1
CD14+_Monocytes12.05
CD19+_BCells(neg._sel.)10.9
CD33+_Myeloid11.6
CD34+14.95
CD4+_Tcells20.9
CD56+_NKCells12.4
CD71+_EarlyErythroid14.4
CD8+_Tcells10.75
CardiacMyocytes14.75
Caudatenucleus35.15
Cerebellum20.3
CerebellumPeduncles35.4
CiliaryGanglion11.9
CingulateCortex33
Colorectaladenocarcinoma10.75
DorsalRootGanglion13.05
FetalThyroid11.65
Fetalbrain21.1
Fetalliver10.95
Fetallung7.6
GlobusPallidus45.95
Heart17
Hypothalamus11.75
Kidney11.75
Leukemia_chronicMyelogenousK-56210.4
Leukemia_promyelocytic-HL-609.65
Leukemialymphoblastic(MOLT-4)8.8
Liver18
Lung10.85
Lymphnode8.65
Lymphoma_burkitts(Daudi)14.65
Lymphoma_burkitts(Raji)16.9
MedullaOblongata25.15
OccipitalLobe15.7
OlfactoryBulb9.15
Ovary11.6
Pancreas9.2
PancreaticIslet11.75
ParietalLobe21.8
Pituitary12.85
Placenta9.8
Pons34.05
PrefrontalCortex32.95
Prostate12.55
Salivarygland10.25
SkeletalMuscle20.5
Skin14.45
SmoothMuscle11.65
Spinalcord16
SubthalamicNucleus36.1
SuperiorCervicalGanglion26.2
TemporalLobe58.75
Testis8.6
TestisGermCell9.1
TestisIntersitial9.2
TestisLeydigCell12.5
TestisSeminiferousTubule10.55
Thalamus22.05
Thymus7.65
Thyroid11.25
Tongue15.95
Tonsil12.55
Trachea8.4
TrigeminalGanglion23.2
Uterus8.25
UterusCorpus17.1
WholeBlood11.85
Wholebrain14.05
colon9.7
pineal_day15.26
pineal_night18.62
retina12.45
small_intestine9.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12827_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.94 ± 0.7
Basal Forebrain8.9 ± 0.36
Basal Part of Pons9.25 ± 0.3
Cerebellar Cortex8.37 ± 0.36
Cerebellar Nuclei7.3 ± 0.98
Claustrum9.77 ± 0.78
Epithalamus6.78 ± 0.99
Frontal Lobe8.43 ± 0.76
Globus Pallidus6.34 ± 1.13
Hypothalamus7.48 ± 0.84
Insula8.85 ± 0.42
Limbic Lobe9.64 ± 0.72
Mesencephalon8.18 ± 0.91
Myelencephalon8.6 ± 0.89
Occipital Lobe9.29 ± 0.85
Parietal Lobe8.71 ± 0.83
Pontine Tegmentum8.39 ± 0.88
Striatum9.97 ± 0.51
Subthalamus7.75 ± 0.13
Temporal Lobe8.8 ± 0.7
Thalamus8.3 ± 0.55
White Matter5.09 ± 0.83
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Centg1CBCerebellum100
100
Centg1CTXCerebral cortex100
100
Centg1HIPHippocampal region100
100
Centg1HPFHippocampal formation100
100
Centg1HYHypothalamus65.02
57.39
Centg1LSXLateral septal complex100
100
Centg1MBMidbrain51.25
45.96
Centg1MYMedulla24.5
23.68
Centg1OLFOlfactory bulb100
100
Centg1PPons24.78
23.09
Centg1PALPallidum65.12
71.18
Centg1RHPRetrohippocampal region100
100
Centg1sAMYStriatum-like amygdalar nuclei100
100
Centg1STRStriatum100
100
Centg1STRdStriatum dorsal region100
100
Centg1STRvStriatum ventral region100
100
Centg1THThalamus51.68
46.89
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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