AutismKB 2.0

Annotation Detail for CLCNKA


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Basic Information Top
Gene Symbol:CLCNKA ( CLCK1,ClC-K1,MGC61490,hClC-Ka )
Gene Full Name: chloride channel Ka
Band: 1p36.13
Quick LinksEntrez ID:1187; OMIM: 602024; Uniprot ID:CLCKA_HUMAN; ENSEMBL ID: ENSG00000186510; HGNC ID: 2026
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult18 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal51 / 336030715
ovarian tumor4 / 7668252
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain23 / 110098920
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney22 / 211777103
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary4 / 10205139
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207047_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.85
Adipocyte7.15
AdrenalCortex9.05
Adrenalgland6.4
Amygdala7.55
Appendix9.05
AtrioventricularNode6.55
BDCA4+_DentriticCells7
Bonemarrow8.1
BronchialEpithelialCells6.9
CD105+_Endothelial7.4
CD14+_Monocytes7.9
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid9.1
CD34+8.7
CD4+_Tcells7.75
CD56+_NKCells8.2
CD71+_EarlyErythroid7.35
CD8+_Tcells6.8
CardiacMyocytes12.85
Caudatenucleus6.45
Cerebellum6.8
CerebellumPeduncles10.5
CiliaryGanglion6.1
CingulateCortex8.05
Colorectaladenocarcinoma7.6
DorsalRootGanglion6
FetalThyroid8.6
Fetalbrain7.35
Fetalliver6.75
Fetallung5.65
GlobusPallidus5.75
Heart18.45
Hypothalamus7.95
Kidney381.15
Leukemia_chronicMyelogenousK-5626.6
Leukemia_promyelocytic-HL-606.6
Leukemialymphoblastic(MOLT-4)5.75
Liver15.25
Lung8.85
Lymphnode6.2
Lymphoma_burkitts(Daudi)9.9
Lymphoma_burkitts(Raji)12.7
MedullaOblongata6.7
OccipitalLobe6.75
OlfactoryBulb5.95
Ovary5.65
Pancreas6.25
PancreaticIslet8.3
ParietalLobe8.55
Pituitary11.5
Placenta7.3
Pons7.55
PrefrontalCortex9.15
Prostate8.9
Salivarygland6.5
SkeletalMuscle11.9
Skin6.7
SmoothMuscle8.2
Spinalcord7.85
SubthalamicNucleus7.35
SuperiorCervicalGanglion9.7
TemporalLobe7.5
Testis6.5
TestisGermCell8.65
TestisIntersitial6.6
TestisLeydigCell7.85
TestisSeminiferousTubule6.7
Thalamus7.65
Thymus5.55
Thyroid44.9
Tongue8.45
Tonsil7.55
Trachea6.15
TrigeminalGanglion9.45
Uterus6.1
UterusCorpus14.8
WholeBlood9.55
Wholebrain5.95
colon7.55
pineal_day15.64
pineal_night13.78
retina9.1
small_intestine7.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_184_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.06 ± 0.73
Basal Forebrain2.58 ± 0.54
Basal Part of Pons2.37 ± 0.68
Cerebellar Cortex2.74 ± 0.67
Cerebellar Nuclei2.37 ± 0.44
Claustrum3.14 ± 0.7
Epithalamus2.18 ± 0.75
Frontal Lobe2.63 ± 0.71
Globus Pallidus2.58 ± 0.77
Hypothalamus2.28 ± 0.62
Insula2.5 ± 0.86
Limbic Lobe2.78 ± 0.79
Mesencephalon2.64 ± 0.7
Myelencephalon2.64 ± 0.75
Occipital Lobe2.62 ± 0.71
Parietal Lobe2.65 ± 0.76
Pontine Tegmentum2.64 ± 0.89
Striatum2.37 ± 0.93
Subthalamus2.4 ± 0.85
Temporal Lobe2.67 ± 0.84
Thalamus2.34 ± 0.78
White Matter3.74 ± 1.86
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018