AutismKB 2.0

Annotation Detail for CLCNKB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CLCNKB ( CLCKB,ClC-K2,ClC-Kb,MGC24087,hClC-Kb )
Gene Full Name: chloride channel Kb
Band: 1p36.13
Quick LinksEntrez ID:1188; OMIM: 602023; Uniprot ID:CLCKB_HUMAN; ENSEMBL ID: ENSG00000184908; HGNC ID: 2027
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult5 / 19391212
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal41 / 336030712
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain4 / 11009893
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine1 / 2344724
kidney30 / 211777141
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207047_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.85
Adipocyte7.15
AdrenalCortex9.05
Adrenalgland6.4
Amygdala7.55
Appendix9.05
AtrioventricularNode6.55
BDCA4+_DentriticCells7
Bonemarrow8.1
BronchialEpithelialCells6.9
CD105+_Endothelial7.4
CD14+_Monocytes7.9
CD19+_BCells(neg._sel.)7.55
CD33+_Myeloid9.1
CD34+8.7
CD4+_Tcells7.75
CD56+_NKCells8.2
CD71+_EarlyErythroid7.35
CD8+_Tcells6.8
CardiacMyocytes12.85
Caudatenucleus6.45
Cerebellum6.8
CerebellumPeduncles10.5
CiliaryGanglion6.1
CingulateCortex8.05
Colorectaladenocarcinoma7.6
DorsalRootGanglion6
FetalThyroid8.6
Fetalbrain7.35
Fetalliver6.75
Fetallung5.65
GlobusPallidus5.75
Heart18.45
Hypothalamus7.95
Kidney381.15
Leukemia_chronicMyelogenousK-5626.6
Leukemia_promyelocytic-HL-606.6
Leukemialymphoblastic(MOLT-4)5.75
Liver15.25
Lung8.85
Lymphnode6.2
Lymphoma_burkitts(Daudi)9.9
Lymphoma_burkitts(Raji)12.7
MedullaOblongata6.7
OccipitalLobe6.75
OlfactoryBulb5.95
Ovary5.65
Pancreas6.25
PancreaticIslet8.3
ParietalLobe8.55
Pituitary11.5
Placenta7.3
Pons7.55
PrefrontalCortex9.15
Prostate8.9
Salivarygland6.5
SkeletalMuscle11.9
Skin6.7
SmoothMuscle8.2
Spinalcord7.85
SubthalamicNucleus7.35
SuperiorCervicalGanglion9.7
TemporalLobe7.5
Testis6.5
TestisGermCell8.65
TestisIntersitial6.6
TestisLeydigCell7.85
TestisSeminiferousTubule6.7
Thalamus7.65
Thymus5.55
Thyroid44.9
Tongue8.45
Tonsil7.55
Trachea6.15
TrigeminalGanglion9.45
Uterus6.1
UterusCorpus14.8
WholeBlood9.55
Wholebrain5.95
colon7.55
pineal_day15.64
pineal_night13.78
retina9.1
small_intestine7.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P149270
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.78 ± 1.29
Basal Forebrain2.18 ± 0.29
Basal Part of Pons1.77 ± 0.49
Cerebellar Cortex3.45 ± 0.72
Cerebellar Nuclei2.58 ± 0.92
Claustrum3.47 ± 1.17
Epithalamus2.85 ± 1.14
Frontal Lobe2.13 ± 0.86
Globus Pallidus2.1 ± 0.67
Hypothalamus2.58 ± 0.86
Insula2.18 ± 0.61
Limbic Lobe2.4 ± 0.99
Mesencephalon2.51 ± 0.93
Myelencephalon2.39 ± 0.88
Occipital Lobe2.17 ± 0.68
Parietal Lobe2.23 ± 1.16
Pontine Tegmentum2.38 ± 0.88
Striatum1.95 ± 0.88
Subthalamus2.59 ± 0.9
Temporal Lobe2.17 ± 0.92
Thalamus2.19 ± 0.77
White Matter2.44 ± 0.36
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018