AutismKB 2.0

Annotation Detail for AGAP4


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Basic Information Top
Gene Symbol:AGAP4 ( CTGLF1,MRIP2 )
Gene Full Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
Band: 10q11.22
Quick LinksEntrez ID:119016; OMIM: NA; Uniprot ID:AGAP4_HUMAN; ENSEMBL ID: ENSG00000188234; HGNC ID: 23459
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus1 / 5640121
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult18 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal22 / 33603076
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine1 / 2344724
kidney2 / 2117779
larynx1 / 2414541
liver2 / 2077439
lung1 / 3369742
lymph0 / 442700 
lymph node6 / 9161065
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221850_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts42.85
Adipocyte38.35
AdrenalCortex46.7
Adrenalgland33.1
Amygdala95.8
Appendix59.35
AtrioventricularNode44.95
BDCA4+_DentriticCells58.4
Bonemarrow37.5
BronchialEpithelialCells32.7
CD105+_Endothelial44.3
CD14+_Monocytes41.45
CD19+_BCells(neg._sel.)56.4
CD33+_Myeloid59.55
CD34+77.85
CD4+_Tcells211.15
CD56+_NKCells60.95
CD71+_EarlyErythroid108.45
CD8+_Tcells333.35
CardiacMyocytes40.45
Caudatenucleus45.4
Cerebellum32.9
CerebellumPeduncles46.6
CiliaryGanglion35.7
CingulateCortex47.7
Colorectaladenocarcinoma74.9
DorsalRootGanglion39
FetalThyroid80.2
Fetalbrain108.25
Fetalliver31.15
Fetallung54.5
GlobusPallidus43.35
Heart49.5
Hypothalamus76.75
Kidney31.5
Leukemia_chronicMyelogenousK-56277.35
Leukemia_promyelocytic-HL-6045.45
Leukemialymphoblastic(MOLT-4)132.4
Liver50.95
Lung49.1
Lymphnode92.1
Lymphoma_burkitts(Daudi)55.7
Lymphoma_burkitts(Raji)125.75
MedullaOblongata59.65
OccipitalLobe56.95
OlfactoryBulb44.2
Ovary36.55
Pancreas57.3
PancreaticIslet60.8
ParietalLobe49.45
Pituitary64.75
Placenta40.7
Pons43.85
PrefrontalCortex94.6
Prostate184.9
Salivarygland39.15
SkeletalMuscle47.5
Skin38.3
SmoothMuscle40.05
Spinalcord49.05
SubthalamicNucleus44.65
SuperiorCervicalGanglion54.7
TemporalLobe35.45
Testis85.2
TestisGermCell198.05
TestisIntersitial228.8
TestisLeydigCell169.4
TestisSeminiferousTubule221.55
Thalamus53.75
Thymus44.3
Thyroid100
Tongue59.25
Tonsil50.05
Trachea32.15
TrigeminalGanglion59.65
Uterus161.45
UterusCorpus36.45
WholeBlood54.3
Wholebrain49.3
colon41
pineal_day88.84
pineal_night113.88
retina73.275
small_intestine40.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P8881
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.68 ± 0.39
Basal Forebrain4.81 ± 0.23
Basal Part of Pons4.85 ± 0.46
Cerebellar Cortex5.07 ± 0.33
Cerebellar Nuclei4.24 ± 0.69
Claustrum4.74 ± 0.91
Epithalamus4.71 ± 0.4
Frontal Lobe4.44 ± 0.46
Globus Pallidus4.64 ± 0.5
Hypothalamus4.22 ± 0.61
Insula4.37 ± 0.57
Limbic Lobe4.74 ± 0.53
Mesencephalon4.59 ± 0.58
Myelencephalon4.63 ± 0.52
Occipital Lobe5.15 ± 0.46
Parietal Lobe4.73 ± 0.5
Pontine Tegmentum4.59 ± 0.65
Striatum4.56 ± 0.44
Subthalamus4.41 ± 0.45
Temporal Lobe4.66 ± 0.51
Thalamus4.53 ± 0.46
White Matter4.9 ± 0.36
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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