AutismKB 2.0

Annotation Detail for CLU


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Basic Information Top
Gene Symbol:CLU ( APOJ,CLI,KUB1,MGC24903,SGP-2,SGP2,SP-40,TRPM-2,TRPM2 )
Gene Full Name: clusterin
Band: 8p21.1
Quick LinksEntrez ID:1191; OMIM: 185430; Uniprot ID:CLUS_HUMAN; ENSEMBL ID: ENSG00000120885; HGNC ID: 2095
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst8 / 62319128
fetus243 / 564012430
neonate4 / 31097128
infant10 / 23620423
juvenile42 / 55556755
adult2569 / 19391211324
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor7 / 12794547
bladder carcinoma1 / 1747557
breast (mammary gland) tumor57 / 94178605
cervical tumor14 / 34366407
chondrosarcoma93 / 828231122
colorectal tumor10 / 11424687
esophageal tumor5 / 17290289
gastrointestinal tumor20 / 119369167
germ cell tumor19 / 26384572
glioma439 / 1068834107
head and neck tumor156 / 1363021144
kidney tumor53 / 68959768
leukemia19 / 95842198
liver tumor19 / 96359197
lung tumor24 / 103127232
lymphoma26 / 71755362
non-neoplasia438 / 972504503
normal2039 / 3360307606
ovarian tumor83 / 766821082
pancreatic tumor39 / 104616372
primitive neuroectodermal tumor of the CNS16 / 125680127
prostate cancer11 / 102680107
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor98 / 902571085
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland15 / 33197451
ascites3 / 4001574
bladder3 / 29757100
blood28 / 123478226
bone70 / 71655976
bone marrow0 / 488010 
brain1934 / 11009891756
cervix21 / 48171435
connective tissue487 / 1492553262
ear6 / 16212370
embryonic tissue31 / 215722143
esophagus5 / 20209247
eye339 / 2110541606
heart9 / 89626100
intestine27 / 234472115
kidney79 / 211777373
larynx34 / 241451408
liver189 / 207743909
lung87 / 336974258
lymph0 / 442700 
lymph node25 / 91610272
mammary gland103 / 153271672
mouth10 / 67052149
muscle25 / 107715232
nerve53 / 157683361
ovary96 / 102051940
pancreas115 / 214812535
parathyroid17 / 20539827
pharynx5 / 41328120
pituitary gland10 / 16585602
placenta77 / 280825274
prostate45 / 189345237
salivary gland7 / 20155347
skin5 / 21057423
spleen2 / 5395237
stomach43 / 96619445
testis207 / 330442626
thymus0 / 811310 
thyroid164 / 474733454
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord4 / 13680292
uterus111 / 232878476
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208792_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.5
Adipocyte664.4
AdrenalCortex2248.15
Adrenalgland1735.1
Amygdala13827.05
Appendix1214.65
AtrioventricularNode2756.5
BDCA4+_DentriticCells40.55
Bonemarrow49.8
BronchialEpithelialCells49
CD105+_Endothelial103.4
CD14+_Monocytes160.15
CD19+_BCells(neg._sel.)72.4
CD33+_Myeloid74.4
CD34+212.6
CD4+_Tcells19.45
CD56+_NKCells28.05
CD71+_EarlyErythroid25.85
CD8+_Tcells25.7
CardiacMyocytes57.65
Caudatenucleus5373.25
Cerebellum4617.35
CerebellumPeduncles5839.05
CiliaryGanglion3061.5
CingulateCortex4681.6
Colorectaladenocarcinoma914
DorsalRootGanglion3089.1
FetalThyroid1190
Fetalbrain1458.05
Fetalliver1829.15
Fetallung655.8
GlobusPallidus3292.4
Heart801.6
Hypothalamus10151.1
Kidney238.6
Leukemia_chronicMyelogenousK-56233.8
Leukemia_promyelocytic-HL-6028.3
Leukemialymphoblastic(MOLT-4)19.95
Liver12744.15
Lung1677.25
Lymphnode914.4
Lymphoma_burkitts(Daudi)28.6
Lymphoma_burkitts(Raji)55.35
MedullaOblongata4215.45
OccipitalLobe6000.3
OlfactoryBulb7614.9
Ovary201.9
Pancreas678.05
PancreaticIslet3448.85
ParietalLobe5831.4
Pituitary1231.25
Placenta194.5
Pons4429.3
PrefrontalCortex15717.6
Prostate1919.35
Salivarygland603.8
SkeletalMuscle81.9
Skin181.45
SmoothMuscle38.3
Spinalcord16504.25
SubthalamicNucleus4158.3
SuperiorCervicalGanglion2837.4
TemporalLobe4695.3
Testis4988.15
TestisGermCell11507.45
TestisIntersitial4780.2
TestisLeydigCell4555.55
TestisSeminiferousTubule5242.9
Thalamus7549.65
Thymus508.25
Thyroid6155.75
Tongue310.25
Tonsil2604.3
Trachea1464.45
TrigeminalGanglion3740.25
Uterus1996
UterusCorpus3183.1
WholeBlood573.9
Wholebrain10162.25
colon625
pineal_day18406.38
pineal_night17253.76
retina17969.5
small_intestine816.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P215913
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.29 ± 0.4
Basal Forebrain11.56 ± 0.15
Basal Part of Pons10.97 ± 0.44
Cerebellar Cortex11.18 ± 0.42
Cerebellar Nuclei10.7 ± 0.56
Claustrum10.51 ± 0.7
Epithalamus12.51 ± 0.5
Frontal Lobe11.63 ± 0.48
Globus Pallidus12 ± 0.37
Hypothalamus11.65 ± 0.42
Insula11.56 ± 0.35
Limbic Lobe11.14 ± 0.56
Mesencephalon11.45 ± 0.55
Myelencephalon11.52 ± 0.42
Occipital Lobe10.96 ± 0.5
Parietal Lobe11.39 ± 0.52
Pontine Tegmentum11.35 ± 0.51
Striatum11.53 ± 0.34
Subthalamus10.85 ± 0.54
Temporal Lobe11.38 ± 0.51
Thalamus11.68 ± 0.41
White Matter10.07 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CluCBCerebellum51.68
57.49
CluCTXCerebral cortex68.27
60.71
CluHIPHippocampal region87.84
91.44
CluHPFHippocampal formation89.61
88.61
CluHYHypothalamus64.02
57.19
CluLSXLateral septal complex95.47
94.22
CluMBMidbrain57.2
58.31
CluMYMedulla62.64
76.59
CluOLFOlfactory bulb84.15
74.74
CluPPons59.98
71.43
CluPALPallidum51.05
45.52
CluRHPRetrohippocampal region90.93
83.7
ClusAMYStriatum-like amygdalar nuclei82.27
80.18
CluSTRStriatum77.77
74.8
CluSTRdStriatum dorsal region73.81
71.44
CluSTRvStriatum ventral region77.13
65.7
CluTHThalamus46.81
49.98
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002080 16 359 374 EILSVDCSTNNPSQAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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