AutismKB 2.0

Annotation Detail for CLIC1


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Basic Information Top
Gene Symbol:CLIC1 ( G6,NCC27 )
Gene Full Name: chloride intracellular channel 1
Band: 6p21.33
Quick LinksEntrez ID:1192; OMIM: 602872; Uniprot ID:CLIC1_HUMAN; ENSEMBL ID: ENSG00000213719; HGNC ID: 2062
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body32 / 70761452
blastocyst20 / 62319320
fetus118 / 564012209
neonate4 / 31097128
infant1 / 2362042
juvenile8 / 55556143
adult509 / 1939121262
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma2 / 17475114
breast (mammary gland) tumor25 / 94178265
cervical tumor13 / 34366378
chondrosarcoma33 / 82823398
colorectal tumor78 / 114246682
esophageal tumor3 / 17290173
gastrointestinal tumor95 / 119369795
germ cell tumor29 / 263845109
glioma30 / 106883280
head and neck tumor24 / 136302176
kidney tumor31 / 68959449
leukemia34 / 95842354
liver tumor54 / 96359560
lung tumor47 / 103127455
lymphoma10 / 71755139
non-neoplasia11 / 97250113
normal644 / 3360307191
ovarian tumor15 / 76682195
pancreatic tumor105 / 1046161003
primitive neuroectodermal tumor of the CNS22 / 125680175
prostate cancer44 / 102680428
retinoblastoma0 / 463560 
skin tumor111 / 124949888
soft tissue/muscle tissue tumor39 / 125191311
uterine tumor38 / 90257421
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland5 / 33197150
ascites27 / 40015674
bladder6 / 29757201
blood63 / 123478510
bone36 / 71655502
bone marrow21 / 48801430
brain70 / 110098963
cervix19 / 48171394
connective tissue21 / 149255140
ear0 / 162120 
embryonic tissue76 / 215722352
esophagus3 / 20209148
eye26 / 211054123
heart26 / 89626290
intestine98 / 234472417
kidney46 / 211777217
larynx2 / 2414582
liver76 / 207743365
lung143 / 336974424
lymph8 / 44270180
lymph node24 / 91610261
mammary gland38 / 153271247
mouth13 / 67052193
muscle5 / 10771546
nerve5 / 15768317
ovary26 / 102051254
pancreas143 / 214812665
parathyroid10 / 20539486
pharynx26 / 41328629
pituitary gland1 / 1658560
placenta69 / 280825245
prostate68 / 189345359
salivary gland24 / 201551190
skin149 / 210574707
spleen4 / 5395274
stomach76 / 96619786
testis21 / 33044263
thymus4 / 8113149
thyroid6 / 47473126
tonsil2 / 16999117
trachea2 / 5241338
umbilical cord3 / 13680219
uterus73 / 232878313
vascular21 / 51780405
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208659_at
Cell line Expression level Expression bar
721_B_lymphoblasts3808
Adipocyte368.25
AdrenalCortex135.85
Adrenalgland142.5
Amygdala14.3
Appendix184.65
AtrioventricularNode77
BDCA4+_DentriticCells2068.95
Bonemarrow718.9
BronchialEpithelialCells2415.35
CD105+_Endothelial838.35
CD14+_Monocytes3229.3
CD19+_BCells(neg._sel.)2227.05
CD33+_Myeloid3698.75
CD34+2996.8
CD4+_Tcells824.4
CD56+_NKCells3796.9
CD71+_EarlyErythroid337.25
CD8+_Tcells985.05
CardiacMyocytes1368.85
Caudatenucleus12
Cerebellum6.15
CerebellumPeduncles13.7
CiliaryGanglion154.3
CingulateCortex10.4
Colorectaladenocarcinoma1055.75
DorsalRootGanglion82.7
FetalThyroid499.25
Fetalbrain15.55
Fetalliver92.75
Fetallung582.15
GlobusPallidus8.45
Heart345.35
Hypothalamus29.9
Kidney194.45
Leukemia_chronicMyelogenousK-5621373.4
Leukemia_promyelocytic-HL-60500
Leukemialymphoblastic(MOLT-4)489
Liver48.2
Lung1093.1
Lymphnode554.3
Lymphoma_burkitts(Daudi)611.4
Lymphoma_burkitts(Raji)348.55
MedullaOblongata8.45
OccipitalLobe11.65
OlfactoryBulb176.25
Ovary138.75
Pancreas661.45
PancreaticIslet660.95
ParietalLobe10.95
Pituitary161.4
Placenta983.75
Pons12.8
PrefrontalCortex15.45
Prostate855.95
Salivarygland158.05
SkeletalMuscle14.75
Skin213.7
SmoothMuscle2275.35
Spinalcord111.05
SubthalamicNucleus10.65
SuperiorCervicalGanglion16.8
TemporalLobe12.55
Testis29.4
TestisGermCell68.9
TestisIntersitial17.8
TestisLeydigCell49.95
TestisSeminiferousTubule13
Thalamus15.1
Thymus859.95
Thyroid515.05
Tongue297.55
Tonsil712.45
Trachea260.9
TrigeminalGanglion95.65
Uterus366.6
UterusCorpus107.35
WholeBlood2985
Wholebrain11.95
colon1065.75
pineal_day198.2
pineal_night197.9
retina157.775
small_intestine926
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13589_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.79 ± 0.6
Basal Forebrain3.65 ± 0.4
Basal Part of Pons4.06 ± 0.57
Cerebellar Cortex4.28 ± 0.46
Cerebellar Nuclei4.54 ± 0.53
Claustrum3.42 ± 0.76
Epithalamus5.23 ± 0.88
Frontal Lobe4.15 ± 0.67
Globus Pallidus4.76 ± 0.44
Hypothalamus4.67 ± 0.89
Insula4.34 ± 0.57
Limbic Lobe4.01 ± 0.6
Mesencephalon4.18 ± 0.63
Myelencephalon4.25 ± 0.72
Occipital Lobe4.34 ± 0.75
Parietal Lobe3.95 ± 0.54
Pontine Tegmentum4.25 ± 0.64
Striatum4.71 ± 0.59
Subthalamus4.26 ± 0.16
Temporal Lobe4.1 ± 0.7
Thalamus4.3 ± 0.66
White Matter3.41 ± 1.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Clic1CBCerebellum62.33
88.7
Clic1CTXCerebral cortex100
100
Clic1HIPHippocampal region73.91
81.34
Clic1HPFHippocampal formation84.66
90.78
Clic1HYHypothalamus73.34
57.75
Clic1LSXLateral septal complex50
50
Clic1MBMidbrain85.48
84.89
Clic1MYMedulla73.82
82.08
Clic1OLFOlfactory bulb100
100
Clic1PPons75.54
82.81
Clic1PALPallidum70.7
60.72
Clic1RHPRetrohippocampal region100
100
Clic1sAMYStriatum-like amygdalar nuclei75.88
65.41
Clic1STRStriatum89.01
71.98
Clic1STRdStriatum dorsal region89.11
69.95
Clic1STRvStriatum ventral region92.98
69.21
Clic1THThalamus66.41
53.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CLIC1_HUMAN_0 0 0 0 GVTFNVTTVDTK PRIDE
CLIC1_HUMAN_0 0 0 0 IGNCPFSQR PRIDE
CLIC1_HUMAN_0 0 0 0 KFLDGNELTLADCNLLPK PRIDE
CLIC1_HUMAN_0 0 0 0 LAALNPESNTAGLDIFAK PRIDE
CLIC1_HUMAN_0 0 0 0 LFMVLWLK PRIDE
CLIC1_HUMAN_0 0 0 0 NSNPALNDNLEK PRIDE
CLIC1_HUMAN_1 28 1 28 AEEQPQVELFVKAGSDGAKIGNCPFSQR PRIDE
CLIC1_HUMAN_113 18 113 130 FSAYIKNSNPALNDNLEK PRIDE
CLIC1_HUMAN_119 12 119 130 NSNPALNDNLEK PRIDE
CLIC1_HUMAN_119 16 119 134 NSNPALNDNLEKGLLK PRIDE
CLIC1_HUMAN_138 27 138 164 VLDNYLTSPLPEEVDETSAEDEGVSQR PRIDE
CLIC1_HUMAN_165 18 165 182 KFLDGNELTLADCNLLPK PRIDE
CLIC1_HUMAN_166 17 166 182 FLDGNELTLADCNLLPK PRIDE
CLIC1_HUMAN_166 26 166 191 FLDGNELTLADCNLLPKLHIVQVVCK PRIDE
CLIC1_HUMAN_183 10 183 192 LHIVQVVCKK PRIDE
CLIC1_HUMAN_183 9 183 191 LHIVQVVCK PRIDE
CLIC1_HUMAN_193 11 193 203 YRGFTIPEAFR PRIDE
CLIC1_HUMAN_195 9 195 203 GFTIPEAFR PRIDE
CLIC1_HUMAN_20 9 20 28 IGNCPFSQR PRIDE
CLIC1_HUMAN_209 8 209 216 YLSNAYAR PRIDE
CLIC1_HUMAN_216 22 216 237 EEFASTCPDDEEIELAYEQVAK PRIDE
CLIC1_HUMAN_217 25 217 241 EEFASTCPDDEEIELAYEQVAKALK PRIDE
CLIC1_HUMAN_29 8 29 36 LFMVLWLK PRIDE
CLIC1_HUMAN_37 12 37 48 GVTFNVTTVDTK PRIDE
CLIC1_HUMAN_37 13 37 49 GVTFNVTTVDTKR PRIDE
CLIC1_HUMAN_95 18 95 112 LAALNPESNTAGLDIFAK PRIDE
PAp00001979 22 217 238 EEFASTCPDDEEIELAYEQVAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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