AutismKB 2.0

Annotation Detail for ADD3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ADD3 ( ADDL )
Gene Full Name: adducin 3 (gamma)
Band: 10q25.1-q25.2
Quick LinksEntrez ID:120; OMIM: 601568; Uniprot ID:ADDG_HUMAN; ENSEMBL ID: ENSG00000148700; HGNC ID: 245
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst6 / 6231996
fetus109 / 564012193
neonate9 / 31097289
infant1 / 2362042
juvenile5 / 5555689
adult249 / 1939121128
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma3 / 17475171
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma17 / 82823205
colorectal tumor17 / 114246148
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor24 / 26384590
glioma7 / 10688365
head and neck tumor13 / 13630295
kidney tumor13 / 68959188
leukemia16 / 95842166
liver tumor7 / 9635972
lung tumor7 / 10312767
lymphoma5 / 7175569
non-neoplasia18 / 97250185
normal625 / 3360307185
ovarian tumor7 / 7668291
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor19 / 90257210
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue4 / 13106305
adrenal gland4 / 33197120
ascites3 / 4001574
bladder2 / 2975767
blood13 / 123478105
bone6 / 7165583
bone marrow10 / 48801204
brain262 / 1100989237
cervix7 / 48171145
connective tissue36 / 149255241
ear17 / 162121048
embryonic tissue28 / 215722129
esophagus0 / 202090 
eye47 / 211054222
heart14 / 89626156
intestine39 / 234472166
kidney50 / 211777236
larynx3 / 24145124
liver17 / 20774381
lung58 / 336974172
lymph1 / 4427022
lymph node28 / 91610305
mammary gland14 / 15327191
mouth11 / 67052164
muscle11 / 107715102
nerve4 / 15768253
ovary15 / 102051146
pancreas24 / 214812111
parathyroid2 / 2053997
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta33 / 280825117
prostate5 / 18934526
salivary gland1 / 2015549
skin20 / 21057494
spleen11 / 53952203
stomach9 / 9661993
testis97 / 330442293
thymus20 / 81131246
thyroid2 / 4747342
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord0 / 136800 
uterus34 / 232878145
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201753_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts261.7
Adipocyte447.1
AdrenalCortex64.85
Adrenalgland43.6
Amygdala1058.5
Appendix209.5
AtrioventricularNode208.7
BDCA4+_DentriticCells449.95
Bonemarrow80.4
BronchialEpithelialCells64.45
CD105+_Endothelial80.3
CD14+_Monocytes328.9
CD19+_BCells(neg._sel.)970.4
CD33+_Myeloid667.55
CD34+163.2
CD4+_Tcells1274.85
CD56+_NKCells1162.6
CD71+_EarlyErythroid19.6
CD8+_Tcells1368.2
CardiacMyocytes342.55
Caudatenucleus338.7
Cerebellum129.7
CerebellumPeduncles265.7
CiliaryGanglion218.55
CingulateCortex321.45
Colorectaladenocarcinoma140.95
DorsalRootGanglion179.65
FetalThyroid343.55
Fetalbrain186
Fetalliver286.8
Fetallung263.95
GlobusPallidus258.4
Heart69.85
Hypothalamus404.05
Kidney109.35
Leukemia_chronicMyelogenousK-56265
Leukemia_promyelocytic-HL-60204.85
Leukemialymphoblastic(MOLT-4)99.45
Liver49.75
Lung47.85
Lymphnode360.45
Lymphoma_burkitts(Daudi)432
Lymphoma_burkitts(Raji)262.5
MedullaOblongata381.15
OccipitalLobe698.65
OlfactoryBulb717.15
Ovary54.75
Pancreas286.65
PancreaticIslet79.3
ParietalLobe382.75
Pituitary537.95
Placenta32.35
Pons178.2
PrefrontalCortex2368.1
Prostate467.45
Salivarygland487.25
SkeletalMuscle41.9
Skin93.3
SmoothMuscle686.25
Spinalcord547.3
SubthalamicNucleus320.05
SuperiorCervicalGanglion239.25
TemporalLobe293.15
Testis83.1
TestisGermCell464
TestisIntersitial245.8
TestisLeydigCell165.95
TestisSeminiferousTubule224.15
Thalamus290.8
Thymus194
Thyroid679.85
Tongue88.65
Tonsil290.25
Trachea230.8
TrigeminalGanglion105.25
Uterus240.15
UterusCorpus64.6
WholeBlood760.9
Wholebrain407.95
colon582.35
pineal_day259.74
pineal_night246.94
retina895.35
small_intestine389.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P202435
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.48 ± 0.46
Basal Forebrain7.66 ± 0.14
Basal Part of Pons6.87 ± 0.35
Cerebellar Cortex7.05 ± 0.24
Cerebellar Nuclei6.7 ± 0.41
Claustrum6.78 ± 0.42
Epithalamus7.82 ± 0.35
Frontal Lobe7.25 ± 0.39
Globus Pallidus8.16 ± 0.34
Hypothalamus7.34 ± 0.42
Insula7.23 ± 0.32
Limbic Lobe7.2 ± 0.47
Mesencephalon7.32 ± 0.47
Myelencephalon7.38 ± 0.46
Occipital Lobe7.4 ± 0.37
Parietal Lobe7.27 ± 0.44
Pontine Tegmentum7.3 ± 0.39
Striatum7.75 ± 0.41
Subthalamus6.9 ± 0.13
Temporal Lobe7.22 ± 0.36
Thalamus7.43 ± 0.4
White Matter7.83 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Add3CBCerebellum52.45
100
Add3CTXCerebral cortex45.15
34.22
Add3HIPHippocampal region72.03
100
Add3HPFHippocampal formation61.96
81.53
Add3HYHypothalamus14.92
11.37
Add3LSXLateral septal complex31.74
23.9
Add3MBMidbrain21.07
20.77
Add3MYMedulla21.42
26.63
Add3OLFOlfactory bulb75.88
74.96
Add3PPons18.98
19.76
Add3PALPallidum16.36
13.04
Add3RHPRetrohippocampal region47.32
42.88
Add3sAMYStriatum-like amygdalar nuclei33.88
24.21
Add3STRStriatum34.72
25.28
Add3STRdStriatum dorsal region32.5
24.16
Add3STRvStriatum ventral region45.94
30.7
Add3THThalamus21.27
19.86
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ADDG_HUMAN_2 20 2 21 SSDASQGVITTPPPPSMPHK PRIDE
ADDG_HUMAN_366 11 366 376 VGEIEFEGLMR PRIDE
ADDG_HUMAN_47 9 47 55 QDFNMMEQR PRIDE
PAp00034779 20 485 504 IEDPNQFVPLNTNPNEVLEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved