AutismKB 2.0

Annotation Detail for HSPB6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:HSPB6 ( FLJ32389,Hsp20 )
Gene Full Name: heat shock protein, alpha-crystallin-related, B6
Band: 19q13.12
Quick LinksEntrez ID:126393; OMIM: 610695; Uniprot ID:HSPB6_HUMAN; ENSEMBL ID: ENSG00000004776; HGNC ID: 26511
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult149 / 193912176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal193 / 336030757
ovarian tumor0 / 766820 
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone5 / 7165569
bone marrow2 / 4880140
brain18 / 110098916
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye18 / 21105485
heart24 / 89626267
intestine10 / 23447242
kidney1 / 2117774
larynx2 / 2414582
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland11 / 15327171
mouth3 / 6705244
muscle79 / 107715733
nerve4 / 15768253
ovary2 / 10205119
pancreas18 / 21481283
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate4 / 18934521
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach4 / 9661941
testis3 / 3304429
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214767_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts37.4
Adipocyte760.7
AdrenalCortex113.25
Adrenalgland271.1
Amygdala86.25
Appendix132.75
AtrioventricularNode60.7
BDCA4+_DentriticCells18.65
Bonemarrow88.1
BronchialEpithelialCells75
CD105+_Endothelial36.8
CD14+_Monocytes49.1
CD19+_BCells(neg._sel.)21.15
CD33+_Myeloid44.35
CD34+37.55
CD4+_Tcells16
CD56+_NKCells16.8
CD71+_EarlyErythroid27.2
CD8+_Tcells20.15
CardiacMyocytes104.9
Caudatenucleus79.55
Cerebellum67.75
CerebellumPeduncles116.35
CiliaryGanglion53.25
CingulateCortex79.15
Colorectaladenocarcinoma78.35
DorsalRootGanglion71.15
FetalThyroid74.25
Fetalbrain76.95
Fetalliver67.5
Fetallung61.4
GlobusPallidus64.5
Heart1359.8
Hypothalamus82.8
Kidney69.55
Leukemia_chronicMyelogenousK-56278.1
Leukemia_promyelocytic-HL-6068.35
Leukemialymphoblastic(MOLT-4)62.55
Liver129.6
Lung112.85
Lymphnode85.95
Lymphoma_burkitts(Daudi)96.3
Lymphoma_burkitts(Raji)112.85
MedullaOblongata71.85
OccipitalLobe69.3
OlfactoryBulb94.3
Ovary770.9
Pancreas97.45
PancreaticIslet86.05
ParietalLobe91.2
Pituitary108.6
Placenta159.2
Pons83.65
PrefrontalCortex105.2
Prostate160
Salivarygland64.25
SkeletalMuscle361.05
Skin91.7
SmoothMuscle88.65
Spinalcord136.35
SubthalamicNucleus74.15
SuperiorCervicalGanglion255.25
TemporalLobe70.1
Testis99.05
TestisGermCell73.2
TestisIntersitial83.65
TestisLeydigCell89.7
TestisSeminiferousTubule98.75
Thalamus78.1
Thymus61.85
Thyroid341.4
Tongue329.85
Tonsil76.5
Trachea70.6
TrigeminalGanglion94.1
Uterus190.55
UterusCorpus169
WholeBlood74.05
Wholebrain63.55
colon159.3
pineal_day88.38
pineal_night68.34
retina282.6
small_intestine108.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P308029
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.99 ± 0.81
Basal Forebrain4.23 ± 0.83
Basal Part of Pons3.9 ± 0.51
Cerebellar Cortex3.5 ± 0.48
Cerebellar Nuclei3.79 ± 0.53
Claustrum4.53 ± 0.62
Epithalamus4.18 ± 0.53
Frontal Lobe3.97 ± 0.78
Globus Pallidus5.72 ± 0.62
Hypothalamus4.23 ± 0.92
Insula3.45 ± 0.89
Limbic Lobe3.76 ± 0.69
Mesencephalon4.57 ± 0.79
Myelencephalon4.22 ± 0.66
Occipital Lobe4.4 ± 0.56
Parietal Lobe4.49 ± 0.65
Pontine Tegmentum4.27 ± 0.87
Striatum4.82 ± 0.51
Subthalamus4.02 ± 0.71
Temporal Lobe3.97 ± 0.71
Thalamus4.58 ± 0.66
White Matter3.93 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hspb6CBCerebellum6.15
6.69
Hspb6CTXCerebral cortex3.62
2.48
Hspb6HIPHippocampal region2.23
2.08
Hspb6HPFHippocampal formation3.71
3.01
Hspb6HYHypothalamus0.48
0.37
Hspb6LSXLateral septal complex0.21
0.15
Hspb6MBMidbrain2.36
2.5
Hspb6MYMedulla4.91
5.49
Hspb6OLFOlfactory bulb6.43
4.64
Hspb6PPons2.1
2.85
Hspb6PALPallidum0.4
0.27
Hspb6RHPRetrohippocampal region6.17
4.3
Hspb6sAMYStriatum-like amygdalar nuclei1.37
0.82
Hspb6STRStriatum1.05
0.81
Hspb6STRdStriatum dorsal region0.97
0.77
Hspb6STRvStriatum ventral region1.47
1.17
Hspb6THThalamus0.93
0.78
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HSPB6_HUMAN_1 13 1 13 MEIPVPVQPSWLR PRIDE
HSPB6_HUMAN_102 13 102 114 HEERPDEHGFVAR PRIDE
HSPB6_HUMAN_103 13 103 115 HEERPDEHGFVAR PRIDE
HSPB6_HUMAN_120 40 120 159 YRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK PRIDE
HSPB6_HUMAN_123 38 123 160 LPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK PRIDE
HSPB6_HUMAN_13 14 13 26 RASAPLPGLSAPGR PRIDE
HSPB6_HUMAN_14 13 14 26 ASAPLPGLSAPGR PRIDE
HSPB6_HUMAN_14 14 14 27 RASAPLPGLSAPGR PRIDE
HSPB6_HUMAN_28 5 28 32 LFDQR PRIDE
HSPB6_HUMAN_32 24 32 55 FGEGLLEAELAALCPTTLAPYYLR PRIDE
HSPB6_HUMAN_57 25 57 81 APSVALPVAQVPTDPGHFSVLLDVK PRIDE
HSPB6_HUMAN_81 10 81 90 HFSPEEIAVK PRIDE
HSPB6_HUMAN_82 10 82 91 HFSPEEIAVK PRIDE
HSPB6_HUMAN_92 11 92 102 VVGEHVEVHAR PRIDE
PAp00067262 24 33 56 FGEGLLEAELAALCPTTLAPYYLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved