AutismKB 2.0

Annotation Detail for CNP


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Basic Information Top
Gene Symbol:CNP ( CNP1 )
Gene Full Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Band: 17q21.2
Quick LinksEntrez ID:1267; OMIM: 123830; Uniprot ID:CN37_HUMAN; ENSEMBL ID: ENSG00000173786; HGNC ID: 2158
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst7 / 62319112
fetus61 / 564012108
neonate13 / 31097418
infant5 / 23620211
juvenile10 / 55556179
adult321 / 1939121165
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma13 / 82823156
colorectal tumor1 / 1142468
esophageal tumor6 / 17290347
gastrointestinal tumor22 / 119369184
germ cell tumor48 / 263845181
glioma37 / 106883346
head and neck tumor18 / 136302132
kidney tumor62 / 68959899
leukemia10 / 95842104
liver tumor14 / 96359145
lung tumor5 / 10312748
lymphoma4 / 7175555
non-neoplasia59 / 97250606
normal1350 / 3360307401
ovarian tumor5 / 7668265
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer23 / 102680223
retinoblastoma11 / 46356237
skin tumor55 / 124949440
soft tissue/muscle tissue tumor29 / 125191231
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland6 / 33197180
ascites12 / 40015299
bladder4 / 29757134
blood14 / 123478113
bone13 / 71655181
bone marrow5 / 48801102
brain1297 / 11009891178
cervix7 / 48171145
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus7 / 20209346
eye37 / 211054175
heart5 / 8962655
intestine14 / 23447259
kidney74 / 211777349
larynx0 / 241450 
liver15 / 20774372
lung26 / 33697477
lymph1 / 4427022
lymph node6 / 9161065
mammary gland13 / 15327184
mouth7 / 67052104
muscle6 / 10771555
nerve1 / 1576863
ovary8 / 10205178
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta27 / 28082596
prostate34 / 189345179
salivary gland7 / 20155347
skin83 / 210574394
spleen7 / 53952129
stomach10 / 96619103
testis31 / 33044293
thymus5 / 8113161
thyroid10 / 47473210
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord3 / 13680219
uterus41 / 232878176
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208912_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts136.3
Adipocyte190.8
AdrenalCortex66.25
Adrenalgland83.75
Amygdala1525.8
Appendix103.25
AtrioventricularNode156.25
BDCA4+_DentriticCells629.2
Bonemarrow50.55
BronchialEpithelialCells98.1
CD105+_Endothelial285.35
CD14+_Monocytes148.75
CD19+_BCells(neg._sel.)113.5
CD33+_Myeloid117.8
CD34+197.35
CD4+_Tcells51.5
CD56+_NKCells151.75
CD71+_EarlyErythroid187.75
CD8+_Tcells41.6
CardiacMyocytes198.5
Caudatenucleus3719.5
Cerebellum991.4
CerebellumPeduncles2647.45
CiliaryGanglion95.35
CingulateCortex2056.8
Colorectaladenocarcinoma299.75
DorsalRootGanglion417.1
FetalThyroid159.95
Fetalbrain212.2
Fetalliver43.1
Fetallung62.25
GlobusPallidus1066
Heart144.5
Hypothalamus4549
Kidney201.2
Leukemia_chronicMyelogenousK-56269
Leukemia_promyelocytic-HL-6067.65
Leukemialymphoblastic(MOLT-4)245.1
Liver134.95
Lung177
Lymphnode60.4
Lymphoma_burkitts(Daudi)123.7
Lymphoma_burkitts(Raji)64.4
MedullaOblongata3571.2
OccipitalLobe5293.2
OlfactoryBulb2069
Ovary22.55
Pancreas35.35
PancreaticIslet290.4
ParietalLobe7978.05
Pituitary115.2
Placenta138.45
Pons2423.7
PrefrontalCortex2823.8
Prostate340.1
Salivarygland39.7
SkeletalMuscle16.8
Skin25.85
SmoothMuscle349.25
Spinalcord4348.6
SubthalamicNucleus1312.25
SuperiorCervicalGanglion64.25
TemporalLobe823.4
Testis88.1
TestisGermCell78.45
TestisIntersitial42.05
TestisLeydigCell35.45
TestisSeminiferousTubule56.3
Thalamus4282.2
Thymus168.3
Thyroid109.2
Tongue55.35
Tonsil156.75
Trachea51.35
TrigeminalGanglion206.9
Uterus103.6
UterusCorpus43.85
WholeBlood76.3
Wholebrain3085.65
colon43
pineal_day159.66
pineal_night169.6
retina2352.875
small_intestine33.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P10798
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.58 ± 0.77
Basal Forebrain6.78 ± 0.62
Basal Part of Pons6.42 ± 0.58
Cerebellar Cortex5.55 ± 0.37
Cerebellar Nuclei7.27 ± 0.89
Claustrum6 ± 0.59
Epithalamus5.75 ± 1.13
Frontal Lobe6.14 ± 0.89
Globus Pallidus8.17 ± 0.48
Hypothalamus5.68 ± 0.91
Insula5.64 ± 0.55
Limbic Lobe5.79 ± 0.81
Mesencephalon6.37 ± 0.85
Myelencephalon6.3 ± 0.81
Occipital Lobe6.31 ± 0.61
Parietal Lobe6.08 ± 0.89
Pontine Tegmentum6.33 ± 0.65
Striatum6.83 ± 0.7
Subthalamus6.36 ± 0.51
Temporal Lobe5.9 ± 0.76
Thalamus6.73 ± 0.53
White Matter9.22 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cnp1CBCerebellum85.45
100
Cnp1CTXCerebral cortex48.66
50.85
Cnp1HIPHippocampal region58.59
82.13
Cnp1HPFHippocampal formation66.13
84.07
Cnp1HYHypothalamus100
100
Cnp1LSXLateral septal complex75.02
88.82
Cnp1MBMidbrain100
100
Cnp1MYMedulla100
100
Cnp1OLFOlfactory bulb69.7
67.59
Cnp1PPons100
100
Cnp1PALPallidum100
100
Cnp1RHPRetrohippocampal region82.99
90.97
Cnp1sAMYStriatum-like amygdalar nuclei67.57
67.86
Cnp1STRStriatum82.07
89.88
Cnp1STRdStriatum dorsal region87.64
100
Cnp1STRvStriatum ventral region70.68
62.07
Cnp1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CN37_HUMAN_183 13 183 195 DFLPLYFGWFLTK PRIDE
CN37_HUMAN_27 23 27 49 DKPELQFPFLQDEDTVATLLECK PRIDE
PAp00001675 23 28 50 DKPELQFPFLQDEDTVATLLECK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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