AutismKB 2.0

Annotation Detail for ADH5


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Basic Information Top
Gene Symbol:ADH5 ( ADH-3,ADHX,FDH,GSNOR )
Gene Full Name: alcohol dehydrogenase 5 (class III), chi polypeptide
Band: 4q23
Quick LinksEntrez ID:128; OMIM: 103710; Uniprot ID:ADHX_HUMAN; ENSEMBL ID: ENSG00000197894; HGNC ID: 253
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body21 / 70761296
blastocyst23 / 62319369
fetus111 / 564012196
neonate13 / 31097418
infant9 / 23620381
juvenile13 / 55556233
adult258 / 1939121133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor10 / 94178106
cervical tumor2 / 3436658
chondrosarcoma26 / 82823313
colorectal tumor11 / 11424696
esophageal tumor5 / 17290289
gastrointestinal tumor21 / 119369175
germ cell tumor62 / 263845234
glioma8 / 10688374
head and neck tumor8 / 13630258
kidney tumor13 / 68959188
leukemia13 / 95842135
liver tumor21 / 96359217
lung tumor10 / 10312796
lymphoma13 / 71755181
non-neoplasia17 / 97250174
normal633 / 3360307188
ovarian tumor8 / 76682104
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS35 / 125680278
prostate cancer14 / 102680136
retinoblastoma5 / 46356107
skin tumor17 / 124949136
soft tissue/muscle tissue tumor17 / 125191135
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites7 / 40015174
bladder6 / 29757201
blood13 / 123478105
bone21 / 71655293
bone marrow6 / 48801122
brain242 / 1100989219
cervix5 / 48171103
connective tissue35 / 149255234
ear2 / 16212123
embryonic tissue71 / 215722329
esophagus5 / 20209247
eye27 / 211054127
heart24 / 89626267
intestine29 / 234472123
kidney41 / 211777193
larynx1 / 2414541
liver47 / 207743226
lung34 / 336974100
lymph8 / 44270180
lymph node20 / 91610218
mammary gland20 / 153271130
mouth6 / 6705289
muscle5 / 10771546
nerve2 / 15768126
ovary14 / 102051137
pancreas14 / 21481265
parathyroid1 / 2053948
pharynx6 / 41328145
pituitary gland1 / 1658560
placenta36 / 280825128
prostate43 / 189345227
salivary gland1 / 2015549
skin37 / 210574175
spleen10 / 53952185
stomach19 / 96619196
testis48 / 330442145
thymus8 / 8113198
thyroid4 / 4747384
tonsil3 / 16999176
trachea19 / 52413362
umbilical cord1 / 1368073
uterus75 / 232878322
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208848_at
Cell line Expression level Expression bar
721_B_lymphoblasts21.7
Adipocyte58.55
AdrenalCortex4.05
Adrenalgland9.65
Amygdala39.3
Appendix11.3
AtrioventricularNode3.95
BDCA4+_DentriticCells14.4
Bonemarrow3.65
BronchialEpithelialCells33.75
CD105+_Endothelial6.05
CD14+_Monocytes8.6
CD19+_BCells(neg._sel.)10.15
CD33+_Myeloid8.95
CD34+22.1
CD4+_Tcells14.7
CD56+_NKCells23.75
CD71+_EarlyErythroid4.1
CD8+_Tcells15.8
CardiacMyocytes18.25
Caudatenucleus9.85
Cerebellum3.9
CerebellumPeduncles5.05
CiliaryGanglion4.1
CingulateCortex6.4
Colorectaladenocarcinoma5.25
DorsalRootGanglion7
FetalThyroid4.55
Fetalbrain20.35
Fetalliver57.05
Fetallung12.15
GlobusPallidus6.65
Heart5.9
Hypothalamus35.1
Kidney24.5
Leukemia_chronicMyelogenousK-5626.3
Leukemia_promyelocytic-HL-608.15
Leukemialymphoblastic(MOLT-4)17.25
Liver6.6
Lung8.6
Lymphnode5.55
Lymphoma_burkitts(Daudi)7.25
Lymphoma_burkitts(Raji)8.8
MedullaOblongata9.35
OccipitalLobe10.7
OlfactoryBulb7.45
Ovary6.4
Pancreas3.4
PancreaticIslet5.25
ParietalLobe6.3
Pituitary11.2
Placenta9.3
Pons7.35
PrefrontalCortex28
Prostate39.9
Salivarygland5.35
SkeletalMuscle4.4
Skin4.45
SmoothMuscle20.1
Spinalcord20.55
SubthalamicNucleus6.65
SuperiorCervicalGanglion7.6
TemporalLobe5.9
Testis15.1
TestisGermCell48.15
TestisIntersitial5.3
TestisLeydigCell8.05
TestisSeminiferousTubule7.2
Thalamus12.15
Thymus10.6
Thyroid36.15
Tongue4.8
Tonsil3.65
Trachea16.35
TrigeminalGanglion5.25
Uterus48.5
UterusCorpus6
WholeBlood5.15
Wholebrain12.9
colon87.1
pineal_day31.82
pineal_night21.86
retina92.65
small_intestine92.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P18692
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.46 ± 0.56
Basal Forebrain7.39 ± 0.31
Basal Part of Pons7.23 ± 0.34
Cerebellar Cortex7.13 ± 0.16
Cerebellar Nuclei7.67 ± 0.32
Claustrum7.28 ± 0.63
Epithalamus7.73 ± 0.32
Frontal Lobe7.6 ± 0.36
Globus Pallidus7.71 ± 0.4
Hypothalamus8.1 ± 0.3
Insula7.87 ± 0.41
Limbic Lobe7.42 ± 0.51
Mesencephalon7.61 ± 0.4
Myelencephalon7.49 ± 0.47
Occipital Lobe7.29 ± 0.39
Parietal Lobe7.53 ± 0.39
Pontine Tegmentum7.63 ± 0.51
Striatum7.57 ± 0.43
Subthalamus8.19 ± 0.37
Temporal Lobe7.56 ± 0.51
Thalamus7.38 ± 0.44
White Matter6.07 ± 0.51
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Adh5CBCerebellum13.12
13.37
Adh5CTXCerebral cortex15.43
5.44
Adh5HIPHippocampal region11.15
7.4
Adh5HPFHippocampal formation12.17
6.08
Adh5HYHypothalamus3.61
1.22
Adh5LSXLateral septal complex1.81
0.68
Adh5MBMidbrain6.48
3.42
Adh5MYMedulla12.84
8.23
Adh5OLFOlfactory bulb12.84
5.57
Adh5PPons7.77
3.86
Adh5PALPallidum5.24
2.19
Adh5RHPRetrohippocampal region13.97
4.49
Adh5sAMYStriatum-like amygdalar nuclei2.44
0.87
Adh5STRStriatum3.08
1.28
Adh5STRdStriatum dorsal region2.38
1.23
Adh5STRvStriatum ventral region6.81
1.95
Adh5THThalamus5.3
2.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ADHX_HUMAN_120 9 120 128 GLMPDGTSR PRIDE
ADHX_HUMAN_218 13 218 230 IIGVDINKDKFAR PRIDE
ADHX_HUMAN_304 8 304 311 PFQLVTGR PRIDE
ADHX_HUMAN_339 27 339 365 IKVDEFVTHNLSFDEINKAFELMHSGK PRIDE
ADHX_HUMAN_357 9 357 365 AFELMHSGK PRIDE
ADHX_HUMAN_84 17 84 100 AGDTVIPLYIPQCGECK PRIDE
ADHX_HUMAN_9 27 9 35 AAVAWEAGKPLSIEEIEVAPPKAHEVR PRIDE
PAp00005028 19 83 101 LKAGDTVIPLYIPQCGECK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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