AutismKB 2.0

Annotation Detail for TMEM18


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Basic Information Top
Gene Symbol:TMEM18 ( DKFZp434C1714 )
Gene Full Name: transmembrane protein 18
Band: 2p25.3
Quick LinksEntrez ID:129787; OMIM: 613220; Uniprot ID:TMM18_HUMAN; ENSEMBL ID: ENSG00000151353; HGNC ID: 25257
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus21 / 56401237
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult51 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma6 / 10688356
head and neck tumor1 / 1363027
kidney tumor5 / 6895972
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal89 / 336030726
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor5 / 12494940
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood3 / 12347824
bone4 / 7165555
bone marrow1 / 4880120
brain20 / 110098918
cervix3 / 4817162
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye8 / 21105437
heart6 / 8962666
intestine10 / 23447242
kidney14 / 21177766
larynx0 / 241450 
liver3 / 20774314
lung7 / 33697420
lymph0 / 442700 
lymph node6 / 9161065
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve1 / 1576863
ovary4 / 10205139
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate3 / 18934515
salivary gland1 / 2015549
skin8 / 21057437
spleen0 / 539520 
stomach1 / 9661910
testis7 / 33044221
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P79599
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.83 ± 0.29
Basal Forebrain8.96 ± 0.19
Basal Part of Pons9.2 ± 0.22
Cerebellar Cortex8.87 ± 0.2
Cerebellar Nuclei9.3 ± 0.23
Claustrum8.82 ± 0.49
Epithalamus9.49 ± 0.31
Frontal Lobe9.1 ± 0.26
Globus Pallidus9.22 ± 0.3
Hypothalamus9.42 ± 0.26
Insula9.19 ± 0.31
Limbic Lobe8.86 ± 0.34
Mesencephalon8.98 ± 0.35
Myelencephalon9.02 ± 0.35
Occipital Lobe8.67 ± 0.33
Parietal Lobe8.93 ± 0.33
Pontine Tegmentum9.08 ± 0.29
Striatum9.1 ± 0.33
Subthalamus9.3 ± 0.33
Temporal Lobe9.16 ± 0.33
Thalamus8.96 ± 0.26
White Matter10.09 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmem18CBCerebellum3.59
4.51
Tmem18CTXCerebral cortex20.16
14.38
Tmem18HIPHippocampal region18.8
19.08
Tmem18HPFHippocampal formation13.33
12.58
Tmem18HYHypothalamus5.63
3.91
Tmem18LSXLateral septal complex7.16
4.37
Tmem18MBMidbrain4.2
4.28
Tmem18MYMedulla4.86
5.77
Tmem18OLFOlfactory bulb17.8
14.76
Tmem18PPons4.3
5.93
Tmem18PALPallidum6.71
5.51
Tmem18RHPRetrohippocampal region5.52
4.72
Tmem18sAMYStriatum-like amygdalar nuclei3.36
2.59
Tmem18STRStriatum5.35
3.8
Tmem18STRdStriatum dorsal region3.1
2.28
Tmem18STRvStriatum ventral region14.04
9.21
Tmem18THThalamus8.02
6.71
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018