AutismKB 2.0

Annotation Detail for AADAC


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Basic Information Top
Gene Symbol:AADAC ( CES5A1,DAC )
Gene Full Name: arylacetamide deacetylase (esterase)
Band: 3q25.1
Quick LinksEntrez ID:13; OMIM: 600338; Uniprot ID:AAAD_HUMAN; ENSEMBL ID: ENSG00000114771; HGNC ID: 17
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus29 / 56401251
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult20 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor6 / 9635962
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal62 / 336030718
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart3 / 8962633
intestine5 / 23447221
kidney0 / 2117770 
larynx0 / 241450 
liver18 / 20774386
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205969_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.6
Adipocyte4.55
AdrenalCortex56.2
Adrenalgland49.3
Amygdala4.7
Appendix4.9
AtrioventricularNode3.65
BDCA4+_DentriticCells4.75
Bonemarrow4.75
BronchialEpithelialCells4.5
CD105+_Endothelial4.6
CD14+_Monocytes4.95
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid5.95
CD34+5.8
CD4+_Tcells5
CD56+_NKCells5.4
CD71+_EarlyErythroid4.35
CD8+_Tcells4.4
CardiacMyocytes6.1
Caudatenucleus4.15
Cerebellum3.8
CerebellumPeduncles5.3
CiliaryGanglion3.55
CingulateCortex4.9
Colorectaladenocarcinoma4.6
DorsalRootGanglion3.8
FetalThyroid4.55
Fetalbrain4.6
Fetalliver72.6
Fetallung9.9
GlobusPallidus3.7
Heart6.05
Hypothalamus4.9
Kidney3.85
Leukemia_chronicMyelogenousK-5624.15
Leukemia_promyelocytic-HL-604.05
Leukemialymphoblastic(MOLT-4)3.7
Liver57.6
Lung4.95
Lymphnode4
Lymphoma_burkitts(Daudi)5.95
Lymphoma_burkitts(Raji)6.6
MedullaOblongata4.2
OccipitalLobe4.15
OlfactoryBulb3.65
Ovary3.1
Pancreas5.2
PancreaticIslet17.7
ParietalLobe5.25
Pituitary5.35
Placenta4.9
Pons4.5
PrefrontalCortex5.75
Prostate5.35
Salivarygland3.7
SkeletalMuscle5.6
Skin3.75
SmoothMuscle5.2
Spinalcord4.95
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.45
TemporalLobe4.35
Testis4
TestisGermCell3.85
TestisIntersitial3.85
TestisLeydigCell4.65
TestisSeminiferousTubule3.95
Thalamus4.75
Thymus3.55
Thyroid5.65
Tongue4.85
Tonsil4.55
Trachea3.85
TrigeminalGanglion4.75
Uterus3.75
UterusCorpus4.35
WholeBlood5
Wholebrain3.85
colon4.6
pineal_day5.7
pineal_night5.56
retina5.5
small_intestine446.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P80570
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.34 ± 1.1
Basal Forebrain1.86 ± 0.28
Basal Part of Pons1.48 ± 0.35
Cerebellar Cortex1.7 ± 0.77
Cerebellar Nuclei2.13 ± 0.73
Claustrum2.76 ± 0.9
Epithalamus1.54 ± 0.77
Frontal Lobe1.68 ± 0.56
Globus Pallidus2.82 ± 1.11
Hypothalamus1.92 ± 0.66
Insula1.74 ± 0.52
Limbic Lobe1.85 ± 0.6
Mesencephalon2.05 ± 0.72
Myelencephalon1.89 ± 0.67
Occipital Lobe1.75 ± 0.42
Parietal Lobe1.86 ± 0.78
Pontine Tegmentum1.91 ± 0.68
Striatum2.05 ± 0.54
Subthalamus1.99 ± 0.75
Temporal Lobe1.77 ± 0.72
Thalamus1.82 ± 0.58
White Matter2.24 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AadacCBCerebellum0
0
AadacCTXCerebral cortex0
0
AadacHIPHippocampal region0
0
AadacHPFHippocampal formation0
0
AadacHYHypothalamus0
0
AadacLSXLateral septal complex0
0
AadacMBMidbrain0
0
AadacMYMedulla0
0
AadacOLFOlfactory bulb0
0
AadacPPons0
0
AadacPALPallidum0
0
AadacRHPRetrohippocampal region0
0
AadacsAMYStriatum-like amygdalar nuclei0
0
AadacSTRStriatum0
0
AadacSTRdStriatum dorsal region0
0
AadacSTRvStriatum ventral region0
0
AadacTHThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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