AutismKB 2.0

Annotation Detail for ICA1L


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Basic Information Top
Gene Symbol:ICA1L ( ALS2CR14,ALS2CR15,DKFZp434E1919,MGC138440 )
Gene Full Name: islet cell autoantigen 1,69kDa-like
Band: 2q33.2
Quick LinksEntrez ID:130026; OMIM: NA; Uniprot ID:ICA1L_HUMAN; ENSEMBL ID: ENSG00000163596; HGNC ID: 14442
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus20 / 56401235
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult35 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor11 / 26384541
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal70 / 336030720
ovarian tumor0 / 766820 
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain46 / 110098941
cervix1 / 4817120
connective tissue6 / 14925540
ear1 / 1621261
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine1 / 2344724
kidney6 / 21177728
larynx0 / 241450 
liver1 / 2077434
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis14 / 33044242
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P211797
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.99 ± 0.27
Basal Forebrain6.93 ± 0.27
Basal Part of Pons6.67 ± 0.28
Cerebellar Cortex7.43 ± 0.24
Cerebellar Nuclei6.19 ± 0.38
Claustrum7.2 ± 0.33
Epithalamus7.46 ± 0.42
Frontal Lobe6.88 ± 0.43
Globus Pallidus6.35 ± 0.17
Hypothalamus6.94 ± 0.26
Insula6.98 ± 0.34
Limbic Lobe7.25 ± 0.43
Mesencephalon6.93 ± 0.47
Myelencephalon6.92 ± 0.4
Occipital Lobe7.29 ± 0.37
Parietal Lobe7.07 ± 0.38
Pontine Tegmentum6.95 ± 0.46
Striatum6.68 ± 0.32
Subthalamus6.83 ± 0.12
Temporal Lobe6.97 ± 0.38
Thalamus6.71 ± 0.3
White Matter6.52 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ica1lCBCerebellum1.79
1.99
Ica1lCTXCerebral cortex5.64
4.21
Ica1lHIPHippocampal region8.85
8.72
Ica1lHPFHippocampal formation6.46
6.03
Ica1lHYHypothalamus0.68
0.64
Ica1lLSXLateral septal complex2.39
1.75
Ica1lMBMidbrain0.88
0.98
Ica1lMYMedulla5.93
7.23
Ica1lOLFOlfactory bulb3.61
2.87
Ica1lPPons0.85
0.93
Ica1lPALPallidum1.73
1.39
Ica1lRHPRetrohippocampal region2.04
1.95
Ica1lsAMYStriatum-like amygdalar nuclei2.17
1.43
Ica1lSTRStriatum1.71
1.37
Ica1lSTRdStriatum dorsal region1.27
1.13
Ica1lSTRvStriatum ventral region2.63
1.88
Ica1lTHThalamus1.57
1.54
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018