AutismKB 2.0

Annotation Detail for COPA


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Basic Information Top
Gene Symbol:COPA ( FLJ26320,HEP-COP )
Gene Full Name: coatomer protein complex, subunit alpha
Band: 1q23.2
Quick LinksEntrez ID:1314; OMIM: 601924; Uniprot ID:COPA_HUMAN; ENSEMBL ID: ENSG00000122218; HGNC ID: 2230
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body21 / 70761296
blastocyst7 / 62319112
fetus104 / 564012184
neonate3 / 3109796
infant0 / 236200 
juvenile11 / 55556197
adult380 / 1939121195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma2 / 17475114
breast (mammary gland) tumor32 / 94178339
cervical tumor6 / 34366174
chondrosarcoma6 / 8282372
colorectal tumor25 / 114246218
esophageal tumor4 / 17290231
gastrointestinal tumor19 / 119369159
germ cell tumor128 / 263845485
glioma9 / 10688384
head and neck tumor50 / 136302366
kidney tumor15 / 68959217
leukemia18 / 95842187
liver tumor32 / 96359332
lung tumor24 / 103127232
lymphoma8 / 71755111
non-neoplasia15 / 97250154
normal603 / 3360307179
ovarian tumor4 / 7668252
pancreatic tumor15 / 104616143
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer8 / 10268077
retinoblastoma9 / 46356194
skin tumor39 / 124949312
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor18 / 90257199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland5 / 33197150
ascites10 / 40015249
bladder2 / 2975767
blood21 / 123478170
bone7 / 7165597
bone marrow16 / 48801327
brain263 / 1100989238
cervix6 / 48171124
connective tissue23 / 149255154
ear4 / 16212246
embryonic tissue46 / 215722213
esophagus4 / 20209197
eye20 / 21105494
heart10 / 89626111
intestine36 / 234472153
kidney29 / 211777136
larynx5 / 24145207
liver42 / 207743202
lung53 / 336974157
lymph8 / 44270180
lymph node7 / 9161076
mammary gland71 / 153271463
mouth30 / 67052447
muscle13 / 107715120
nerve1 / 1576863
ovary8 / 10205178
pancreas30 / 214812139
parathyroid5 / 20539243
pharynx9 / 41328217
pituitary gland1 / 1658560
placenta58 / 280825206
prostate12 / 18934563
salivary gland3 / 20155148
skin48 / 210574227
spleen8 / 53952148
stomach16 / 96619165
testis129 / 330442390
thymus14 / 81131172
thyroid13 / 47473273
tonsil3 / 16999176
trachea34 / 52413648
umbilical cord2 / 13680146
uterus54 / 232878231
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208684_at
Cell line Expression level Expression bar
721_B_lymphoblasts601.15
Adipocyte283.8
AdrenalCortex140.95
Adrenalgland190.45
Amygdala325.8
Appendix59.15
AtrioventricularNode22.65
BDCA4+_DentriticCells841.65
Bonemarrow188.85
BronchialEpithelialCells372.35
CD105+_Endothelial159.1
CD14+_Monocytes483.2
CD19+_BCells(neg._sel.)179.85
CD33+_Myeloid945.55
CD34+484.3
CD4+_Tcells293.4
CD56+_NKCells473.4
CD71+_EarlyErythroid216.55
CD8+_Tcells297.9
CardiacMyocytes368.35
Caudatenucleus213.55
Cerebellum165.35
CerebellumPeduncles262.45
CiliaryGanglion75.65
CingulateCortex163.45
Colorectaladenocarcinoma222.3
DorsalRootGanglion87.2
FetalThyroid122.55
Fetalbrain201.65
Fetalliver181.2
Fetallung245.1
GlobusPallidus64.15
Heart85.7
Hypothalamus392.9
Kidney136.6
Leukemia_chronicMyelogenousK-562450.35
Leukemia_promyelocytic-HL-60122.55
Leukemialymphoblastic(MOLT-4)147.45
Liver150
Lung174.65
Lymphnode168.6
Lymphoma_burkitts(Daudi)152.5
Lymphoma_burkitts(Raji)192.05
MedullaOblongata245.55
OccipitalLobe223.4
OlfactoryBulb144.75
Ovary141.9
Pancreas110.85
PancreaticIslet300
ParietalLobe253.85
Pituitary634.95
Placenta461.95
Pons114.3
PrefrontalCortex446.85
Prostate219.95
Salivarygland87.9
SkeletalMuscle34.05
Skin43.5
SmoothMuscle765.05
Spinalcord180.55
SubthalamicNucleus106.75
SuperiorCervicalGanglion75.95
TemporalLobe135.45
Testis107.45
TestisGermCell120
TestisIntersitial56.25
TestisLeydigCell51.15
TestisSeminiferousTubule39.6
Thalamus233.15
Thymus346.4
Thyroid451.2
Tongue91.1
Tonsil215.1
Trachea258.35
TrigeminalGanglion34.75
Uterus176.7
UterusCorpus127.6
WholeBlood214.65
Wholebrain190.85
colon181.8
pineal_day539.06
pineal_night523.82
retina349.975
small_intestine270.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P325932
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.58 ± 0.35
Basal Forebrain6.74 ± 0.19
Basal Part of Pons6.92 ± 0.24
Cerebellar Cortex6.65 ± 0.27
Cerebellar Nuclei7.1 ± 0.16
Claustrum6.83 ± 0.37
Epithalamus6.5 ± 0.51
Frontal Lobe6.72 ± 0.3
Globus Pallidus6.81 ± 0.28
Hypothalamus6.77 ± 0.32
Insula6.54 ± 0.28
Limbic Lobe6.7 ± 0.31
Mesencephalon6.74 ± 0.34
Myelencephalon6.7 ± 0.34
Occipital Lobe6.77 ± 0.33
Parietal Lobe6.85 ± 0.32
Pontine Tegmentum6.72 ± 0.3
Striatum6.55 ± 0.32
Subthalamus7.04 ± 0.31
Temporal Lobe6.7 ± 0.29
Thalamus6.69 ± 0.3
White Matter7.67 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
CopaCBCerebellum0
0
CopaCTXCerebral cortex0
0
CopaHIPHippocampal region0
0
CopaHPFHippocampal formation0
0
CopaHYHypothalamus0
0
CopaLSXLateral septal complex0
0
CopaMBMidbrain0
0
CopaMYMedulla0
0
CopaOLFOlfactory bulb0
0
CopaPPons0
0
CopaPALPallidum0
0
CopaRHPRetrohippocampal region0
0
CopasAMYStriatum-like amygdalar nuclei0
0
CopaSTRStriatum0
0
CopaSTRdStriatum dorsal region0
0
CopaSTRvStriatum ventral region0
0
CopaTHThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
COPA_HUMAN_1 11 1 11 MLTKFETKSAR PRIDE
COPA_HUMAN_1030 14 1030 1043 SILLSVPLLVVDNK PRIDE
COPA_HUMAN_1031 14 1031 1044 SILLSVPLLVVDNK PRIDE
COPA_HUMAN_1202 15 1202 1216 VTTVTEIGKDVIGLR PRIDE
COPA_HUMAN_170 12 170 181 NLSPGAVESDVR PRIDE
COPA_HUMAN_171 12 171 182 NLSPGAVESDVR PRIDE
COPA_HUMAN_183 16 183 198 GITGVDLFGTTDAVVK PRIDE
COPA_HUMAN_206 21 206 226 GVNWAAFHPTMPLIVSGADDR PRIDE
COPA_HUMAN_207 21 207 227 GVNWAAFHPTMPLIVSGADDR PRIDE
COPA_HUMAN_261 14 261 274 QELILSNSEDKSIR PRIDE
COPA_HUMAN_351 8 351 358 DVAVMQLR PRIDE
COPA_HUMAN_39 16 39 54 MCTLIDKFDEHDGPVR PRIDE
COPA_HUMAN_468 13 468 480 DADSITLFDVQQK PRIDE
COPA_HUMAN_563 10 563 572 TLDLPIYVTR PRIDE
COPA_HUMAN_588 10 588 597 VLTIDPTEFK PRIDE
COPA_HUMAN_607 10 607 616 KYDEVLHMVR PRIDE
COPA_HUMAN_608 9 608 616 YDEVLHMVR PRIDE
COPA_HUMAN_620 12 620 631 LVGQSIIAYLQK PRIDE
COPA_HUMAN_793 22 793 814 LLQPPAPIMPLDTNWPLLTVSK PRIDE
COPA_HUMAN_816 10 816 825 GFFEGTIASK PRIDE
COPA_HUMAN_941 15 941 955 LLHDQVGVIQFGPYK PRIDE
PAp00001268 13 1185 1197 CPLSGACYSPEFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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