AutismKB 2.0

Annotation Detail for KLF6


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Basic Information Top
Gene Symbol:KLF6 ( BCD1,CBA1,COPEB,CPBP,DKFZp686N0199,GBF,PAC1,ST12,ZF9 )
Gene Full Name: Kruppel-like factor 6
Band: 10p15.2
Quick LinksEntrez ID:1316; OMIM: 602053; Uniprot ID:KLF6_HUMAN; ENSEMBL ID: ENSG00000067082; HGNC ID: 2235
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body21 / 70761296
blastocyst1 / 6231916
fetus65 / 564012115
neonate2 / 3109764
infant2 / 2362084
juvenile4 / 5555671
adult358 / 1939121184
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma17 / 82823205
colorectal tumor18 / 114246157
esophageal tumor3 / 17290173
gastrointestinal tumor23 / 119369192
germ cell tumor14 / 26384553
glioma11 / 106883102
head and neck tumor18 / 136302132
kidney tumor7 / 68959101
leukemia35 / 95842365
liver tumor10 / 96359103
lung tumor21 / 103127203
lymphoma0 / 717550 
non-neoplasia10 / 97250102
normal481 / 3360307143
ovarian tumor14 / 76682182
pancreatic tumor25 / 104616238
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor18 / 124949144
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue8 / 13106610
adrenal gland1 / 3319730
ascites10 / 40015249
bladder1 / 2975733
blood36 / 123478291
bone9 / 71655125
bone marrow3 / 4880161
brain88 / 110098979
cervix0 / 481710 
connective tissue17 / 149255113
ear2 / 16212123
embryonic tissue40 / 215722185
esophagus4 / 20209197
eye46 / 211054217
heart4 / 8962644
intestine60 / 234472255
kidney26 / 211777122
larynx2 / 2414582
liver34 / 207743163
lung68 / 336974201
lymph0 / 442700 
lymph node12 / 91610130
mammary gland39 / 153271254
mouth3 / 6705244
muscle4 / 10771537
nerve4 / 15768253
ovary18 / 102051176
pancreas45 / 214812209
parathyroid2 / 2053997
pharynx14 / 41328338
pituitary gland0 / 165850 
placenta16 / 28082556
prostate16 / 18934584
salivary gland0 / 201550 
skin38 / 210574180
spleen6 / 53952111
stomach14 / 96619144
testis10 / 33044230
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus49 / 232878210
vascular12 / 51780231
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208960_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts28.4
Adipocyte43
AdrenalCortex39.6
Adrenalgland21.55
Amygdala16.8
Appendix27.9
AtrioventricularNode32.6
BDCA4+_DentriticCells659.25
Bonemarrow35.15
BronchialEpithelialCells104.6
CD105+_Endothelial32.9
CD14+_Monocytes359.85
CD19+_BCells(neg._sel.)521
CD33+_Myeloid1270.4
CD34+70.2
CD4+_Tcells499.85
CD56+_NKCells304.55
CD71+_EarlyErythroid26.1
CD8+_Tcells315.4
CardiacMyocytes39.3
Caudatenucleus24.6
Cerebellum22
CerebellumPeduncles31.5
CiliaryGanglion30.85
CingulateCortex28.35
Colorectaladenocarcinoma27.7
DorsalRootGanglion26.2
FetalThyroid26.45
Fetalbrain27.5
Fetalliver16.85
Fetallung23.3
GlobusPallidus20.4
Heart31.3
Hypothalamus24.25
Kidney22.45
Leukemia_chronicMyelogenousK-56218.95
Leukemia_promyelocytic-HL-6016.95
Leukemialymphoblastic(MOLT-4)20
Liver21.3
Lung318.1
Lymphnode23.95
Lymphoma_burkitts(Daudi)30.65
Lymphoma_burkitts(Raji)30.85
MedullaOblongata24.75
OccipitalLobe24.25
OlfactoryBulb53.1
Ovary21.4
Pancreas29.75
PancreaticIslet29.6
ParietalLobe29.55
Pituitary32.4
Placenta30.3
Pons26.25
PrefrontalCortex27.7
Prostate32.5
Salivarygland22.1
SkeletalMuscle37.35
Skin35.35
SmoothMuscle31.3
Spinalcord29.5
SubthalamicNucleus27.3
SuperiorCervicalGanglion31.25
TemporalLobe23.65
Testis18.9
TestisGermCell23.3
TestisIntersitial23.05
TestisLeydigCell27.4
TestisSeminiferousTubule23.75
Thalamus27.15
Thymus21.8
Thyroid32.35
Tongue27.45
Tonsil36.1
Trachea31.2
TrigeminalGanglion34.8
Uterus27.65
UterusCorpus24.8
WholeBlood46.4
Wholebrain12.1
colon109.85
pineal_day25.9
pineal_night24.48
retina35.4
small_intestine26.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P252739
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.47 ± 0.97
Basal Forebrain1.95 ± 0.37
Basal Part of Pons1.77 ± 0.47
Cerebellar Cortex2.25 ± 0.8
Cerebellar Nuclei2.37 ± 0.72
Claustrum3.01 ± 0.81
Epithalamus1.95 ± 0.78
Frontal Lobe1.94 ± 0.68
Globus Pallidus2.58 ± 0.69
Hypothalamus2.17 ± 0.67
Insula1.71 ± 0.37
Limbic Lobe2.07 ± 0.85
Mesencephalon2.31 ± 0.7
Myelencephalon2.11 ± 0.71
Occipital Lobe2.07 ± 0.64
Parietal Lobe2.07 ± 0.86
Pontine Tegmentum2.07 ± 0.7
Striatum2.01 ± 0.62
Subthalamus2.15 ± 0.67
Temporal Lobe1.92 ± 0.69
Thalamus2.02 ± 0.61
White Matter2.57 ± 0.62
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klf6CBCerebellum5.79
6.16
Klf6CTXCerebral cortex7.61
5.23
Klf6HIPHippocampal region2.95
2.72
Klf6HPFHippocampal formation4.56
3.89
Klf6HYHypothalamus0.77
0.66
Klf6LSXLateral septal complex0.36
0.4
Klf6MBMidbrain3.63
3.76
Klf6MYMedulla4.2
4.42
Klf6OLFOlfactory bulb4.24
3.34
Klf6PPons3.83
4.06
Klf6PALPallidum2.18
2.68
Klf6RHPRetrohippocampal region7.71
5.88
Klf6sAMYStriatum-like amygdalar nuclei0.77
0.65
Klf6STRStriatum2.26
2.06
Klf6STRdStriatum dorsal region2.92
2.75
Klf6STRvStriatum ventral region1.72
1.33
Klf6THThalamus8.19
6.47
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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