AutismKB 2.0

Annotation Detail for TPRA1


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Basic Information Top
Gene Symbol:TPRA1 ( FLJ32197,GPR175,TMEM227,TPRA40 )
Gene Full Name: transmembrane protein, adipocyte asscociated 1
Band: 3q21.3
Quick LinksEntrez ID:131601; OMIM: 608336; Uniprot ID:TPRA1_HUMAN; ENSEMBL ID: ENSG00000163870; HGNC ID: 30413
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus14 / 56401224
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult98 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor7 / 34366203
chondrosarcoma12 / 82823144
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor9 / 26384534
glioma5 / 10688346
head and neck tumor2 / 13630214
kidney tumor5 / 6895972
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma8 / 71755111
non-neoplasia1 / 9725010
normal95 / 336030728
ovarian tumor5 / 7668265
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer5 / 10268048
retinoblastoma1 / 4635621
skin tumor4 / 12494932
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone6 / 7165583
bone marrow0 / 488010 
brain34 / 110098930
cervix7 / 48171145
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine7 / 23447229
kidney5 / 21177723
larynx1 / 2414541
liver1 / 2077434
lung8 / 33697423
lymph4 / 4427090
lymph node5 / 9161054
mammary gland6 / 15327139
mouth1 / 6705214
muscle0 / 1077150 
nerve3 / 15768190
ovary9 / 10205188
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate6 / 18934531
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach6 / 9661962
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218855_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.8
Adipocyte4.85
AdrenalCortex5.5
Adrenalgland4.15
Amygdala5
Appendix4.9
AtrioventricularNode3.7
BDCA4+_DentriticCells8.1
Bonemarrow7.2
BronchialEpithelialCells12.05
CD105+_Endothelial33.65
CD14+_Monocytes8.8
CD19+_BCells(neg._sel.)6.75
CD33+_Myeloid16.2
CD34+15.05
CD4+_Tcells12.1
CD56+_NKCells10.2
CD71+_EarlyErythroid69.5
CD8+_Tcells11.1
CardiacMyocytes10
Caudatenucleus4.1
Cerebellum4
CerebellumPeduncles5.6
CiliaryGanglion3.15
CingulateCortex4.4
Colorectaladenocarcinoma33.75
DorsalRootGanglion3.6
FetalThyroid4.7
Fetalbrain4.8
Fetalliver4.3
Fetallung6.2
GlobusPallidus3.6
Heart14.7
Hypothalamus5.05
Kidney4
Leukemia_chronicMyelogenousK-5625.5
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)5.25
Liver14.2
Lung73.55
Lymphnode4.9
Lymphoma_burkitts(Daudi)6.4
Lymphoma_burkitts(Raji)26.55
MedullaOblongata4.4
OccipitalLobe4
OlfactoryBulb4.25
Ovary3.25
Pancreas4.05
PancreaticIslet4.6
ParietalLobe4.7
Pituitary5.5
Placenta13.2
Pons4.15
PrefrontalCortex6.25
Prostate23.05
Salivarygland3.8
SkeletalMuscle5.15
Skin3.55
SmoothMuscle10.15
Spinalcord6.9
SubthalamicNucleus3.8
SuperiorCervicalGanglion5
TemporalLobe4.3
Testis6.3
TestisGermCell3.95
TestisIntersitial4.05
TestisLeydigCell4.8
TestisSeminiferousTubule4.15
Thalamus4.7
Thymus4.2
Thyroid22.6
Tongue4.65
Tonsil4.8
Trachea4.1
TrigeminalGanglion4.4
Uterus8.8
UterusCorpus4.45
WholeBlood5.35
Wholebrain4.2
colon4.95
pineal_day8.76
pineal_night11.18
retina9.35
small_intestine4.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8759_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.24 ± 0.55
Basal Forebrain4.22 ± 0.33
Basal Part of Pons4.32 ± 0.32
Cerebellar Cortex4.36 ± 0.5
Cerebellar Nuclei4.28 ± 0.47
Claustrum4.26 ± 0.73
Epithalamus4.03 ± 0.34
Frontal Lobe4.38 ± 0.47
Globus Pallidus4.48 ± 0.41
Hypothalamus4.47 ± 0.39
Insula4.19 ± 0.56
Limbic Lobe4.28 ± 0.44
Mesencephalon4.33 ± 0.43
Myelencephalon4.35 ± 0.47
Occipital Lobe4.13 ± 0.38
Parietal Lobe4.21 ± 0.46
Pontine Tegmentum4.12 ± 0.58
Striatum4.18 ± 0.53
Subthalamus4.23 ± 0.68
Temporal Lobe4.32 ± 0.42
Thalamus4.26 ± 0.54
White Matter4.65 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gpr175CBCerebellum27.85
33.23
Gpr175CTXCerebral cortex15.22
10.93
Gpr175HIPHippocampal region11.11
10.06
Gpr175HPFHippocampal formation13.92
11.53
Gpr175HYHypothalamus22.94
16.9
Gpr175LSXLateral septal complex5.27
3.89
Gpr175MBMidbrain31.46
26.71
Gpr175MYMedulla40.78
41.99
Gpr175OLFOlfactory bulb17.48
13.24
Gpr175PPons34.57
33.66
Gpr175PALPallidum16.91
14.24
Gpr175RHPRetrohippocampal region18.59
13.51
Gpr175sAMYStriatum-like amygdalar nuclei15.95
11.21
Gpr175STRStriatum6.73
4.92
Gpr175STRdStriatum dorsal region4.92
3.82
Gpr175STRvStriatum ventral region9.51
6.18
Gpr175THThalamus27.49
21.21
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00039751 21 296 316 CQVDETEEPDVHLPQPYAVAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018